Capivasertib Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 10, 2024.

Applies to capivasertib: oral tablets film-coated.

Side effects include:

Most common adverse effects (incidence ≥20%): diarrhea, cutaneous adverse reactions, increased random glucose, decreased lymphocytes, decreased hemoglobin, increased fasting glucose, nausea, fatigue, decreased leukocytes, increased triglycerides, decreased neutrophils, increased creatinine, vomiting, stomatitis.

For healthcare professionals

Applies to capivasertib: oral tablet.

General adverse events

Most common adverse reactions/laboratory abnormalities occurring in at least 20% of patients included diarrhea, cutaneous adverse reactions, increased random glucose, decreased lymphocytes, decreased hemoglobin, increased fasting glucose, nausea, fatigue, decreased leukocytes, increased triglycerides, decreased neutrophils, increased creatinine, vomiting, and stomatitis.^[Ref]

Dermatologic

• Very common (10% or more): Cutaneous adverse reactions (up to 56%)

Cutaneous adverse reactions included butterfly rash, dermatitis, allergic dermatitis, dry skin, eczema, erythema multiforme, hand dermatitis, palmar-plantar erythrodysesthesia syndrome, pruritus, rash, erythematous rash, maculo-papular rash, papular rash, skin discoloration, skin fissures, skin reaction, skin ulcer, urticaria, purpura, erythema and drug eruption.

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 77%), nausea (up to 35%), stomatitis (up to 25%), vomiting (up to 21%)
• Frequency not reported: Dysgeusia, dyspepsia

Hematologic

• Very common (10% or more): Decreased lymphocytes (up to 49%), decreased hemoglobin (up to 47%), decreased leukocytes (up to 35%), increased triglycerides (up to 30%), decreased neutrophils (up to 25%), decreased platelets (up to 12%)
• Frequency not reported: Anemia

Hepatic

• Very common (10% or more): Increased alanine aminotransferase (up to 23%)

Hypersensitivity

• Frequency not reported: Hypersensitivity, including anaphylactic reaction

Metabolic

• Very common (10% or more): Increased random glucose (up to 58%), increased fasting glucose (up to 37%), hyperglycemia (up to 19%), decreased corrected calcium (up to 19%), decreased appetite (up to 17%), decreased potassium (up to 17%)

Hyperglycemia included increased blood glucose, increased glycosylated hemoglobin, impaired glucose tolerance, diabetes mellitus, and hyperglycemia.

Other

• Very common (10% or more): Fatigue (up to 38%)
• Frequency not reported: Pyrexia

Renal

• Very common (10% or more): Increased creatinine (up to 19%), urinary tract infection (up to 14%), renal injury (up to 11%)

Renal injury includes acute kidney injury, renal failure, renal impairment, decreased glomerular filtration rate, increased creatinine, and proteinuria.

Respiratory

• Frequency not reported: Pneumonia

Nervous system

• Very common (10% or more): Headache (up to 17%)

Further information

Capivasertib side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer