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C1 Esterase Inhibitor (human) Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 19, 2024.

Applies to C1 esterase inhibitor (human): powder for solution.

Other dosage forms:

Serious side effects

Along with its needed effects, C1 esterase inhibitor (human) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking C1 esterase inhibitor (human):

More common side effects

  • chest pain or tightness
  • head congestion
  • hoarseness or other voice changes
  • nausea
  • pain or tenderness around the eyes and cheekbones
  • rash
  • sore throat
  • trouble breathing
  • vomiting

Less common side effects

  • bleeding gums
  • collection of blood under the skin
  • coughing up blood
  • deep, dark purple bruise
  • difficulty with swallowing
  • dizziness
  • hard lump
  • headache
  • increased menstrual flow or vaginal bleeding
  • itching, pain, flushing, redness, or swelling of the skin
  • nosebleeds
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • swelling
  • unusually warm skin

Incidence not known

  • confusion
  • difficulty with speaking
  • dizziness
  • double vision
  • fast heartbeat
  • general tiredness and weakness
  • hives
  • inability to move the arms, legs, or facial muscles
  • numbness or tingling in the face, arms, or legs
  • pain, redness, or swelling in the arm or leg
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • slow speech
  • trouble speaking, thinking, or walking

Other side effects

Some side effects of C1 esterase inhibitor (human) may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • diarrhea
  • headache
  • pain
  • stomach pain

Less common side effects

  • bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • change in taste
  • fever
  • loss of taste
  • muscle aches
  • pain at the catheter site
  • stuffy or runny nose
  • unusual tiredness or weakness

Managing side effects (general information)

For healthcare professionals

Applies to C1 esterase inhibitor (human): intravenous kit, intravenous powder for injection, subcutaneous powder for injection.

Respiratory adverse events

Respiratory side effects have included sinusitis, bronchitis, upper respiratory tract infection, and viral upper respiratory tract infection.[Ref]

Nervous system

Nervous system side effects have included headache.[Ref]

Musculoskeletal

Musculoskeletal side effects have included limb injury, back pain, and pain in extremity.[Ref]

Dermatologic

Dermatologic side effects have included pruritus.[Ref]

Cardiovascular

Cardiovascular side effects have included postmarketing reports of thrombotic events including deep vein thrombosis, myocardial infarction, and transient ischemic attack.[Ref]

References

1. (2022) "Product Information. Cinryze (C1 esterase inhibitor, human)." ViroPharma Incorporated

2. Gandhi PK, Gentry WM, Bottorff MB (2012) "Thrombotic events associated with C1 esterase inhibitor products in patients with hereditary angioedema: investigation from the United States Food and Drug Administration adverse event reporting system database." Pharmacotherapy, 32, p. 902-9

Frequently asked questions

Further information

C1 esterase inhibitor (human) side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer