Betrixaban Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 8, 2023.

Applies to betrixaban: oral capsule.

Important warnings This medicine can cause some serious health issues

Oral route (capsule)

Spinal/Epidural Hematoma: Epidural or spinal hematomas may occur in patients treated with betrixaban who are receiving neuraxial anesthesia or undergoing spinal puncture.

The risk of these events may be increased by the use of in-dwelling epidural catheters or concomitant use of medical products affecting hemostasis.

These hematomas may result in long-term or permanent paralysis.

Consider these risks when scheduling patients for spinal procedures.

Serious side effects of betrixaban

Along with its needed effects, betrixaban may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking betrixaban:

More common side effects

• bleeding gums
• coughing up blood
• difficulty in breathing or swallowing
• dizziness
• headache
• increased menstrual flow or vaginal bleeding
• nosebleeds
• paralysis
• prolonged bleeding from cuts
• red or black, tarry stools
• red or dark brown urine

Less common side effects

• bladder pain
• bloody or cloudy urine
• blurred vision
• decreased urine
• difficult, burning, or painful urination
• dizziness
• dry mouth
• frequent urge to urinate
• increased thirst
• irregular heartbeat
• loss of appetite
• lower back or side pain
• mood changes
• muscle pain or cramps
• nausea or vomiting
• nervousness
• numbness or tingling in the hands, feet, or lips
• pounding in the ears
• seizures
• unusual tiredness or weakness

Other side effects of betrixaban

Some side effects of betrixaban may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• constipation
• diarrhea

Incidence not known

• fever
• joint or muscle pain
• redness and soreness of the eyes
• skin rash
• sores in the mouth
• stomach pain
• swelling of the feet or lower legs

For healthcare professionals

Applies to betrixaban: oral capsule.

General adverse events

The most common adverse events were related to bleeding.^[Ref]

Hematologic

• Common (1% to 10%): Clinically relevant non-major bleeding
• Uncommon (0.1% to 1%): Major bleeding (gastrointestinal, intracranial, and fatal)

Cardiovascular

• Common (1% to 10%): Hypertension^[Ref]

Metabolic

• Common (1% to 10%): Hypokalemia^[Ref]

Gastrointestinal

• Common (1% to 10%): Constipation, nausea, diarrhea^[Ref]

Respiratory

• Common (1% to 10%): Epistaxis^[Ref]

Nervous system

• Common (1% to 10%): Headache^[Ref]

Hypersensitivity

• Rare (less than 0.1%): Moderate hypersensitivity^[Ref]

Further information

Betrixaban side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer