Benzoyl Peroxide / Sulfur Topical Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 14, 2024.

Applies to benzoyl peroxide/sulfur topical: topical gel, topical lotion.

Important warnings This medicine can cause some serious health issues

Benzoyl peroxide can cause a rare but serious allergic reaction or severe skin irritation. Stop using the medicine and get emergency medical help if you have: hives, itching; difficult breathing, feeling light-headed; or swelling of your face, lips, tongue, or throat.

Do not use benzoyl peroxide and sulfur topical while you are also using tretinoin (Altinac, Avita, Renova, Retin-A, Tretin-X).

Benzoyl peroxide can cause a rare but serious allergic reaction or severe skin irritation. These reactions may occur just a few minutes after you apply the medicine, or within a day or longer afterward.

Stop using this medicine and Get emergency medical help if you have any of these signs of an allergic reaction while taking benzoyl peroxide / sulfur topical: hives, itching; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat.

Stop using the medicine if it causes severe burning or excessive dryness or irritation.

Common side effects may include:

• mild burning or stinging after applying the medicine; or

• redness, dryness, or peeling of treated skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to benzoyl peroxide / sulfur topical: topical gel, topical lotion.

Dermatologic adverse events

Dermatologic side effects have most frequently included excessive erythema and peeling (5%).^[Ref]

Excessive erythema and peeling occur most often during the initial phase of drug use and may be controlled by reducing the frequency of application.^[Ref]

Hypersensitivity

Hypersensitivity reactions in the form of contact sensitization have been reported and are expected to occur in 1% to 2.5% of patients.^[Ref]

Further information

Benzoyl peroxide/sulfur topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer