Ampyra Side Effects

Generic name: dalfampridine

Medically reviewed by Drugs.com. Last updated on Apr 6, 2024.

Note: This document provides detailed information about Ampyra Side Effects associated with dalfampridine. Some dosage forms listed on this page may not apply specifically to the brand name Ampyra.

Applies to dalfampridine: oral tablet extended release.

Serious side effects of Ampyra

Along with its needed effects, dalfampridine (the active ingredient contained in Ampyra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dalfampridine:

More common side effects

• bladder pain
• bloody or cloudy urine
• difficult, burning, or painful urination
• frequent urge to urinate
• lower back or side pain

Less common side effects

• blurred vision
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• difficulty controlling your bladder or bowels
• feeling sad or depressed
• forgetful
• muscle cramps
• problems with swallowing
• slurred speech
• unusual tiredness or weakness

Incidence not known

• chest tightness
• cough
• dizziness or lightheadedness
• fast heartbeat
• feeling of constant movement of self or surroundings
• hives, itching, skin rash
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• sensation of spinning
• vomiting

Get emergency help immediately if any of the following symptoms of overdose occur while taking dalfampridine:

Symptoms of overdose

• confusion
• increased sweating
• memory loss
• reduced awareness
• seizures
• weakness

Other side effects of Ampyra

Some side effects of dalfampridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• headache
• lack or loss of strength
• nausea
• problems with balance
• trouble sleeping

Less common side effects

• back pain
• constipation
• fever
• muscle aches
• sore throat
• stomach discomfort, upset, or pain
• stuffy or runny nose

For healthcare professionals

Applies to dalfampridine: oral tablet extended release.

Nervous system adverse events

• Common (1% to 10%): Dizziness, headache, balance disorder, multiple sclerosis relapse, paresthesia, tremor
• Uncommon (0.1% to 1%): Seizure, exacerbation of trigeminal neuralgia^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, constipation, dyspepsia
• Postmarketing reports: Vomiting^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain^[Ref]

Respiratory

• Common (1% to 10%): Nasopharyngitis, pharyngolaryngeal pain, dyspnea^[Ref]

Genitourinary

• Very common (10% or more): Urinary tract infection (12%)^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Anaphylaxis, angioedema, hypersensitivity^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia, anxiety^[Ref]

Other

• Common (1% to 10%): Asthenia
• Uncommon (0.1% to 1%): Chest discomfort^[Ref]

Cardiovascular

• Common (1% to 10%): Palpitations^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Rash, urticaria^[Ref]

Further information

Ampyra side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer