Amondys 45 Side Effects
Generic name: casimersen
Medically reviewed by Drugs.com. Last updated on Jul 28, 2024.
Note: This document provides detailed information about Amondys 45 Side Effects associated with casimersen. Some dosage forms listed on this page may not apply specifically to the brand name Amondys 45.
Applies to casimersen: intravenous solution.
Serious side effects of Amondys 45
Along with its needed effects, casimersen (the active ingredient contained in Amondys 45) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking casimersen:
More common
- body aches or pain
- chills
- cough
- difficulty in moving
- dizziness
- ear congestion
- fast, pounding, or irregular heartbeat
- fever
- headache
- joint pain
- lightheadedness
- loss of voice
- muscle pain or stiffness
- nausea
- runny or stuffy nose
- sneezing
- sore throat
- stomach pain
- swelling of the face, ankles, or hands
- tender, swollen glands in the neck
- trouble breathing
- trouble swallowing
- unusual tiredness or weakness
- vomiting
Incidence not known
- agitation
- blood in the urine
- coma
- confusion
- decreased urine output
- depression
- irritability
- lethargy
- muscle twitching
- rapid weight gain
- seizures
- stupor
Other side effects of Amondys 45
Some side effects of casimersen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- change in hearing
- earache or pain in the ear
- ear drainage
For healthcare professionals
Applies to casimersen: intravenous solution.
General
The most commonly reported adverse reactions have included respiratory tract infection, cough, pyrexia, headache, arthralgia, and oropharyngeal pain.[Ref]
Nervous system
- Very common (10% or more): Headache (32%)
Other
- Very common (10% or more): Pyrexia (33%)
- Frequency not reported: Ear pain, ear infection, posttraumatic pain
Musculoskeletal
- Very common (10% or more): Arthralgia (21%)
Gastrointestinal
- Very common (10% or more): Oropharyngeal pain (21%)
- Frequency not reported: Nausea
Respiratory
- Very common (10% or more): Respiratory tract infections (65%), cough (33%)
Respiratory tract infections include pharyngitis, nasopharyngitis, and rhinitis. In clinical trials, respiratory tract infections were reported in 65% of patients receiving the drug compared to 55% in the placebo group. Cough was reported in 33% of patients receiving this drug compared to 26% in placebo.
References
1. (2021) "Product Information. Amondys 45 (casimersen)." Sarepta Therapeutics
Frequently asked questions
More about Amondys 45 (casimersen)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: miscellaneous uncategorized agents
- En español
Patient resources
Professional resources
Related treatment guides
Further information
Amondys 45 side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.