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Amifostine Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 10, 2023.

Applies to amifostine: intravenous powder for solution.

Serious side effects of amifostine

Along with its needed effects, amifostine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking amifostine:

More common

  • blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when suddenly getting up from a lying or sitting position
  • fainting or loss of consciousness
  • fast or irregular breathing
  • itching
  • nausea, vomiting
  • red, scaly, swollen, or peeling areas of the skin
  • skin rash
  • sweating
  • swelling of the eyes or eyelids
  • tightness in the chest
  • trouble with breathing
  • unusual tiredness or weakness

Rare

  • blistering, peeling, or loosening of the skin
  • burning or tingling sensation
  • chills
  • cough
  • cracks in the skin
  • diarrhea
  • fast, slow, or irregular heartbeat or pulse
  • fever
  • joint or muscle pain
  • loss of bladder control
  • loss of heat from the body
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle spasm or jerking of all extremities
  • no blood pressure or pulse
  • numbness and tingling around the mouth, fingertips, or feet
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • seizures
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • stomach cramps
  • stopping of the heart
  • sudden loss of consciousness
  • tremor

Incidence not known

  • bloody urine
  • decreased frequency or amount of urine
  • difficulty with swallowing
  • hives or welts
  • hoarseness
  • increased blood pressure
  • increased thirst
  • lower back or side pain
  • loss of appetite
  • pain or discomfort in the arms, jaw, back, or neck
  • slow or irregular breathing
  • swelling of the face, fingers, or lower legs
  • weight gain

Other side effects of amifostine

Some side effects of amifostine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

  • feeling unusually warm or cold
  • flushing or redness of the face or neck
  • headache
  • hiccups
  • nervousness
  • pounding in the ears
  • sleepiness (severe)
  • sneezing

Incidence not known

  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For healthcare professionals

Applies to amifostine: intravenous powder for injection.

Cardiovascular

Gastrointestinal

Other

Hypersensitivity

Dermatologic

Nervous system

Metabolic

Local

Swelling, phlebitis[Ref]

Ocular

Respiratory

Renal

References

1. (2001) "Product Information. Ethyol (amifostine)." Alza

Further information

Amifostine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.