Altretamine Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 15, 2024.

Applies to altretamine: oral capsule.

Important warnings This medicine can cause some serious health issues

You should not use altretamine if you have severe nerve problems or severe bone marrow suppression.

Altretamine can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often.

Altretamine can affect your nervous system. Call your doctor at once if you have severe dizziness, fainting, seizure, or severe numbness, tingling, or cold feeling in your hands or feet.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using altretamine and call your doctor at once if you have:

• severe numbness, tingling, or cold feeling in your hands or feet;

• severe or continuous vomiting;

• fever, chills, flu symptoms, mouth sores, pale skin, easy bruising or bleeding, unusual weakness;

• a light-headed feeling, like you might pass out;

• severe dizziness or spinning sensation;

• seizure (convulsions); or

• upper stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

• mild nausea or vomiting;

• mild numbness or tingling;

• loss of appetite;

• mood changes, mild dizziness; or

• skin rash, itching, hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to altretamine: oral capsule.

Hematologic adverse events

• Very common (10% or more): Anemia (33%)
• Common (1% to 10%): Thrombocytopenia, leukopenia^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea and vomiting (33%)
• Common (1% to 10%): Increased alkaline phosphatase^[Ref]

Nervous system

• Very common (10% or more): Peripheral sensory neuropathy (31%)
• Common (1% to 10%): Seizures
• Frequency not reported: CNS symptoms (mood disorders, disorders of consciousness, ataxia, dizziness, vertigo)^[Ref]

Renal

• Common (1% to 10%): Increased BUN, increased serum creatinine^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Anorexia^[Ref]

Other

• Uncommon (0.1% to 1%): Fatigue^[Ref]

Hepatic

• Frequency not reported: Hepatic toxicity^[Ref]

Dermatologic

• Frequency not reported: Skin rash, pruritus, alopecia^[Ref]

Further information

Altretamine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer