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Clotrimazole topical Pregnancy and Breastfeeding Warnings

Brand names: Abtrim, Abtrim Pessaries, Canesten, Canesten 1, Canesten 3, Canesten 6 Day Pessary, Clotrimazole-3, Clotrimazole-7, Desenex Antifungal Cream, Femcare, FungiCURE Pump Spray, Gyne-Lotrimin, Gyne-Lotrimin 3 Day, Gyne-Lotrimin Inserts, Lotrimin AF Athlete's Foot Cream, Lotrimin AF For Her Athlete's Foot Cream, Lotrimin AF Jock Itch Cream, Lotrimin AF Ringworm Cream, Mycelex, Mycelex OTC, Trivagizole 3

Medically reviewed by Drugs.com. Last updated on Aug 1, 2023.

Clotrimazole topical Pregnancy Warnings

Clotrimazole topical has been assigned to pregnancy category B by the FDA. Systemic absorption is minimal following topical or vaginal administration. Animals given high doses intravaginally have not revealed evidence of teratogenicity. High oral doses resulted in embryotoxicity and maternal toxicity. In clinical trials involving women in their second and third trimester, clotrimazole treatment of vaginal candidiasis was not associated with fetal harm. Clotrimazole use has not been well studied during the first trimester. Clotrimazole should only be used during the first trimester when need has been clearly established.

See references

Clotrimazole topical Breastfeeding Warnings

There are no data on the excretion of clotrimazole into human milk. However, systemic absorption is minimal after topical and vaginal administration. The manufacturer recommends that caution be used when administering clotrimazole topical to nursing women.

See references

See also

References for pregnancy information

  1. Haram K, Digranes A (1978) "Vulvovaginal candidiasis in pregnancy treated with clotrimazole." Acta Obstet Gynecol Scand, 57, p. 453-5
  2. Tan CG, Good CS, Milne LJ, Loudon JD (1974) "A comparative trial of six day therapy with clotrimazole and nystatin in pregnant patients with vaginal candidiasis." Postgrad Med J, 50 Suppl 1, p. 102-5
  3. Lindeque BG, van Niekerk WA (1984) "Treatment of vaginal candidiasis in pregnancy with a single clotrimazole 500 mg vaginal pessary." S Afr Med J, 65, p. 123-4
  4. Frerich W, Gad A (1977) "The frequency of Candida infections in pregnancy and their treatment with clotrimazole." Curr Med Res Opin, 4, p. 640-4
  5. (2001) "Product Information. Mycelex (clotrimazole)." Bayer
  6. (2003) "Product Information. Lotrimin (clotrimazole topical)." Schering-Plough Corporation

References for breastfeeding information

  1. (2003) "Product Information. Lotrimin (clotrimazole topical)." Schering-Plough Corporation

Further information

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