Skip to main content

Ventilatory Burden Can Assess Severity of Obstructive Sleep Apnea

Medically reviewed by Drugs.com.

By Elana Gotkine HealthDay Reporter

MONDAY, Sept. 18, 2023 -- Automated ventilatory burden, which represents the proportion of overnight breaths with <50 percent normalized amplitude, can measure the severity of obstructive sleep apnea (OSA), according to a study published online Sept. 12 in the American Journal of Respiratory and Critical Care Medicine.

Noting that the apnea-hypopnea index (AHI) used for diagnosis of OSA has demonstrable limitations, Ankit Parekh, Ph.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues proposed a novel automated measure, ventilatory burden, and examined its ability to overcome these limitations. Data were included from two epidemiological cohorts -- the Sao Paolo Epidemiological Study (EPISONO) and Sleep Heart Health Study (SHHS) -- as well as two retrospective clinical cohorts, Relating Sleep Disordered Breathing to Daytime Function (DAYFUN) and New York University Center for Brain Health.

The researchers found that in asymptomatic healthy participants, the 95th percentile of ventilatory burden was 25.2 and 26.7 percent across the EPISONO and DAYFUN cohorts, respectively. There was an association seen for ventilatory burden with the degree of upper airway obstruction in a dose-response manner; ventilatory burden also exhibited low night-to-night variability. Before and after adjustment for covariates including hypoxic burden, ventilatory burden was predictive of all-cause and cardiovascular disease mortality in the SHHS cohort. AHI predicted all-cause mortality but was not linked to cardiovascular disease mortality in the SHHS cohort.

"Clinicians who rely on arbitrary rules and thresholds for assessing severity of sleep apnea will now have a better validated tool to better manage sleep apnea and patients can receive the best care earlier," Parekh said in a statement.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2024 HealthDay. All rights reserved.

Posted September 2023

Read this next

AI-Assisted Contours Superior to Cognitively Defined Prostate Cancer Contours

WEDNESDAY, July 3, 2024 -- Artificial intelligence (AI)-assisted definition of prostate cancer contours reduces underestimation of the extent of prostate cancer, according to a...

Mean Cost of Bringing New Drug to U.S. Market Is $879.3 Million

TUESDAY, July 2, 2024 -- The mean cost of developing a new drug for the U.S. market is estimated to be $879.3 million when both drug development failure and capital costs are...

Patient–Primary Care Provider Language Concordance Tied to Better Outcomes

TUESDAY, July 2, 2024 -- Patient-family physician language concordance is associated with a lower risk for adverse outcomes, according to a study published online June 3...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.