Systemic Immune-Inflammation Index Tied to Mortality in CKD
By Lori Solomon HealthDay Reporter
TUESDAY, Sept. 24, 2024 -- There is a J-shaped association between systemic immune-inflammation index (SII) levels and all-cause mortality in patients with chronic kidney disease (CKD), according to a study published online Sept. 10 in Immunity, Inflammation and Disease.
Meng Jia, from the Shanghai University of Traditional Chinese Medicine, and colleagues investigated the association between SII and all-cause mortality in individuals with CKD. The analysis included 9,303 people with CKD participating in the National Health and Nutrition Examination Survey (1999 to 2018).
The researchers found that during a median follow-up of 86 months, there was a distinctive J-shaped relationship between SII level and all-cause mortality. The nadir was seen at an SII level of 478.93 in the second quartile. The risk for all-cause mortality increased per increment of one standard deviation of SII once SII exceeded 478.93 (hazard ratio, 1.13). There was an association between elevated SII and an increased risk for all-cause mortality among patients with CKD (quartile 4 versus quartile 2: hazard ratio, 1.23). The correlation between SII and CKD mortality was particularly pronounced for participants older than 60 years and for individuals with diabetes. When removing the extreme 5 percent outliers of SII, there was a linear positive association between SII and all-cause mortality.
"The SII index, encompassing platelet, neutrophil, and lymphocyte counts, offers a more comprehensive representation of the equilibrium between inflammatory status and host immune response," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted September 2024
Read this next
Guidance Provided for Management of Obesity in Kidney Disease
MONDAY, Sept. 23, 2024 -- In a report issued by the American Society of Nephrology and published online Sept. 18 in the Journal of the American Society of Nephrology, guidance is...
Homelessness Linked to ESKD, Death in Veterans With Incident CKD
FRIDAY, Sept. 20, 2024 -- For veterans with incident chronic kidney disease (CKD), a history of homelessness is associated with an increased risk for end-stage kidney disease...
Tivozanib Has Efficacy in Advanced Renal Cell Carcinoma Post-ICI Therapy
FRIDAY, Sept. 20, 2024 -- For patients with metastatic renal cell carcinoma (mRCC) and progression during or after one to two prior lines of therapy, including one immune...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.