• All News
• Consumer
• Pro
• New Drugs
• Pipeline
• Clinical Trials
• FDA Alerts

Risk Factor Control May Modify Link Between HIV Status and Heart Disease

Medically reviewed by Carmen Pope, BPharm. Last updated on Jan 22, 2024.

By Elana Gotkine HealthDay Reporter

MONDAY, Jan. 22, 2024 -- Control of dyslipidemia and diabetes, but not hypertension, reduces the association of HIV status with cardiovascular disease (CVD), according to a study published online Jan. 16 in Clinical Infectious Diseases.

Michael J. Silverberg, Ph.D., M.P.H., from Kaiser Permanente Northern California in Oakland, and colleagues conducted a retrospective cohort study involving 8,285 people with HIV (PWH) and 170,517 people without HIV (PWoH) from an integrated health system. Control of risk factors, including hypertension, dyslipidemia, diabetes, and other modifiable factors, was measured using a novel disease management index (DMI), accounting for amount/duration above treatment goals (0 to 100 percent [perfect control]).

The researchers found that PWH and PWoH had similar DMIs (80 to 100 percent) apart from triglycerides, which was worse for PWH, and hemoglobin A1c, which was better for PWH. Compared with PWoH, PWH had an increased risk for CVD in adjusted models (hazard ratio, 1.18). In subgroups with controlled dyslipidemia and diabetes, the association was attenuated; however, it remained elevated for PWH with controlled hypertension or higher total cholesterol. The subgroup with frequent unhealthy alcohol use had the strongest HIV status association with CVD (hazard ratio, 2.13).

"While effective control of dyslipidemia and diabetes may help reduce the CVD disparity in PWH, elevated CVD risks are concerning despite well-controlled hypertension," the authors write.

Two authors disclosed ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2024 HealthDay. All rights reserved.

Posted January 2024

More news resources

• FDA Medwatch Drug Alerts
• Daily MedNews
• News for Health Professionals
• New Drug Approvals
• New Drug Applications
• Drug Shortages
• Clinical Trial Results
• Generic Drug Approvals

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.