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No Association Found for Autoimmune Disease, Monoclonal Gammopathy

Medically reviewed by Carmen Pope, BPharm. Last updated on May 21, 2024.

By Elana Gotkine HealthDay Reporter

MONDAY, May 20, 2024 -- In a systematically screened population, there is no association between autoimmune disease and monoclonal gammopathy of undetermined significance (MGUS), according to a study published online May 21 in the Annals of Internal Medicine.

Ingigerdur Sverrisdottir, M.D., from the University of Iceland in Reykjavik, and colleagues conducted a cross-sectional study within a prospective, population-based screening study of MGUS to examine whether MGUS is associated with autoimmune diseases. Data were obtained from an Icelandic population of adults aged 40 years or older, with 75,422 persons screened for MGUS.

The researchers found that 10,818 participants had an autoimmune disorder, of whom 599 had MGUS (61 with prior diagnosis; 538 diagnosed at study screening). There was no association for diagnosis of an autoimmune disease with MGUS (prevalence ratio, 1.05; 95 percent confidence interval, 0.97 to 1.15). However, an association was seen for autoimmune disease diagnoses with a prior clinical diagnosis of MGUS (prevalence ratio, 2.11; 95 percent confidence interval, 1.64 to 2.70).

"Our findings have direct clinical relevance because they suggest that recommendations to routinely screen patients with autoimmune disease for MGUS may not be warranted," the authors write.

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Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2024 HealthDay. All rights reserved.

Posted May 2024

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