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Mean Platelet Volume Linked to Mortality in Peritoneal Dialysis Patients

Medically reviewed by Carmen Pope, BPharm. Last updated on Nov 22, 2023.

By Elana Gotkine HealthDay Reporter

WEDNESDAY, Nov. 22, 2023 -- For patients treated with peritoneal dialysis (PD), mean platelet volume (MPV) is associated with all-cause mortality and cardiovascular mortality, according to a study published online Nov. 8 in BMC Cardiovascular Disorders.

Jianghai Wang, from the Dongying People's Hospital in China, and colleagues estimated the relationship between MPV and all-cause and cardiovascular mortality among 1,322 patients treated with PD. The associations were assessed in three models: Model 1 was unadjusted; model 2 was adjusted for age, gender, Charlson comorbidity index, diabetes, hypertension, premorbid cardiovascular diseases, body mass index, and antiplatelet medication; and model 3 had further adjustment for hemoglobin, albumin, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.

A total of 360 deaths were recorded during a median follow-up of 50 months. The researchers found that the risk for all-cause mortality was considerably higher among patients with MPV ≥10.2 fL in all three models (hazard ratios, 0.68, 0.70, and 0.73, respectively). The risk for cardiovascular mortality was also higher among patients with MPV ≥10.2 fL in models 1, 2, and 3 (hazard ratios, 0.63, 0.66, and 0.69, respectively).

"Our findings suggest that high levels of MPV (MPV ≥10.2 fL) is an independent hazards and biological marker for all-cause and cardiovascular mortality in patients treated with PD," the authors write.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

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Posted November 2023

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