Inflammation, Cholesterol, Lipoprotein(a) Predict 30-Year Cardiovascular Outcomes in Women
By Lori Solomon HealthDay Reporter
TUESDAY, Sept. 3, 2024 -- A single combined measure of high-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels predict the 30-year risk for incident cardiovascular events in healthy U.S. women, according to a study published online Aug. 31 in the New England Journal of Medicine to coincide with the European Society of Cardiology Congress 2024, held from Aug. 30 to Sept. 2 in London.
Paul M. Ridker, M.D., from Brigham and Women's Hospital in Boston, and colleagues measured high-sensitivity CRP, LDL cholesterol, and lipoprotein(a) levels at baseline in 27,939 initially healthy U.S. women who were followed for 30 years. Usefulness of these biomarkers for predicting cardiovascular risk was assessed.
The researchers found that quintiles of increasing baseline levels of high-sensitivity CRP, LDL cholesterol, and lipoprotein(a) all predicted 30-year risks. For the primary end point of first major adverse cardiovascular event, risk was higher in the top versus bottom quintile (adjusted hazard ratios, 1.70, 1.36, and 1.33 for high-sensitivity CRP, LDL cholesterol, and lipoprotein (a), respectively). Consistent findings were seen for the individual outcomes of coronary heart disease and stroke. Each biomarker independently contributed to overall risk.
"These data support efforts to extend strategies for the primary prevention of atherosclerotic events beyond traditional 10-year estimates of risk," the authors write.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted September 2024
Read this next
Weekly Mobile Phone Use Increases Risk for New Cardiovascular Disease Over Time
THURSDAY, Sept. 5, 2024 -- Weekly mobile phone usage is positively associated with incident cardiovascular disease (CVD) risk over 12 years, according to a study published online...
Report Reveals Extent of Cost-Related Medication Nonadherence in Seniors
THURSDAY, Sept. 5, 2024 -- About 3.5 percent of older adults do not take prescription medications due to cost and a similar percentage do not take medications as prescribed due to...
Errors in Racial Data Likely in Electronic Medical Records
THURSDAY, Sept. 5, 2024 -- There are significant errors in recording racial data in children’s electronic medical records (EMRs) across health systems, according to a study...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.