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Ichthyosis Tied to Increased Risk of Depression, Anxiety

Medically reviewed by Carmen Pope, BPharm. Last updated on Dec 1, 2023.

By Lori Solomon HealthDay Reporter

FRIDAY, Dec. 1, 2023 -- Ichthyosis is associated with increased likelihood of depression and anxiety, according to a research letter published online Oct. 18 in the Journal of the American Academy of Dermatology.

Gloria Chen, from the Yale School of Medicine in New Haven, Connecticut, and colleagues investigated the relationship between ichthyosis and clinical diagnoses of depression and anxiety. Analysis included 334 congenital ichthyosis cases and 1,336 matched controls identified through the All of Us Research Program.

The researchers found that individuals with ichthyosis were more likely to have diagnoses of depression (41.9 versus 23.8 percent) and anxiety (15.9 versus 7.0 percent) than matched controls. When adjusting for smoking status and hypothyroidism, ichthyosis was significantly associated with depression (odds ratio, 2.33) and anxiety (odds ratio, 2.48).

"Our findings of increased risk of depression and anxiety in individuals with ichthyosis highlight the need for routine quality of life and mental health assessments in this population as a standard of care," the authors write. "Attention to this important aspect of these disorders is essential for optimal care of the entire patient."

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Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

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Posted December 2023

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