Higher BMI Variability Linked to Adverse Cardiovascular Disease Events
By Elana Gotkine HealthDay Reporter
MONDAY, March 25, 2024 -- Higher body mass index (BMI) variability is associated with adverse cardiovascular disease (CVD) events, according to a study published online March 21 in JAMA Network Open.
Zakaria Almuwaqqat, M.D., M.P.H., from the Veterans Affairs Atlanta Healthcare System in Decatur, Georgia, and colleagues examined the association between BMI variability and incident CVD events in two cohorts (the Million Veteran Program [MVP] and the U.K. Biobank [UKB]).
There were 4,811 composite CVD events recorded from 2011 to 2018 among the 92,363 U.S. veterans in the MVP cohort. The researchers found that the coefficient of variation of BMI was associated with an increased risk for composite CVD across all groups (hazard ratio, 1.16). Among subgroups and after adjustment for the polygenic score of BMI, these associations were unchanged. There were 6,934 composite CVD events among the 65,047 individuals in the UKB cohort. The risk for cardiovascular death increased significantly for each one-standard deviation increase in BMI variability in the UKB cohort (hazard ratio, 1.08).
"These findings suggest that greater BMI changes could be related to a high-risk phenotype for CVD, with unique metabolic and genetic mechanisms," the authors write. "Future studies should focus on identifying molecular risk pathways mediating this association."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted March 2024
Read this next
Good Heart Health May Protect Against Cognitive Decline in Black Women
WEDNESDAY, April 24, 2024 -- Middle-aged Black women with better heart health are less likely to show a decline in mental function, according to a study published online April 24...
AI May Be Useful in Polypharmacy Management
WEDNESDAY, April 24, 2024 -- ChatGPT shows promise in polypharmacy management and deprescribing medications among the elderly, according to a study published online April 18 in...
Higher Dietary Quality at Breast Cancer Diagnosis Linked to Lower CVD Risk
TUESDAY, April 23, 2024 -- Higher diet quality at diagnosis of breast cancer is associated with a lower risk for cardiovascular disease (CVD) events and death, especially the...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.