Graded Association ID'd for Depressive Symptoms With Mortality Risk
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
TUESDAY, Oct. 17, 2023 -- Depressive symptoms in adults are associated with mortality in a graded association, according to a study published online Oct. 9 in JAMA Network Open.
Zefeng Zhang, M.D., Ph.D., from the U.S. Centers for Disease Control and Prevention in Atlanta, and colleagues conducted a prospective cohort study to examine the association between depressive symptoms and mortality in a large, nationally representative sample of 23,694 U.S. adults.
The prevalence of mild depression was 14.9 percent, and prevalence of moderate-to-severe depression was 7.2 percent. The researchers found that the hazard ratios (with 95 percent confidence intervals) were 1.35 (1.07 to 1.72) and 1.62 (1.24 to 2.12) for all-cause mortality for mild and moderate-to-severe depressive symptoms versus none. The corresponding hazard ratios (95 percent confidence intervals) were 1.49 (1.11 to 2.00) and 1.79 (1.22 to 2.62) for cardiovascular disease (CVD) mortality and 0.96 (0.58 to 1.60) and 2.21 (1.24 to 3.91) for ischemic heart disease mortality. Across subgroups, the associations were largely consistent. Lifestyle factors explained about 11.0 to 16.1 percent of the associations between depression and mortality. Independent associations were seen for feeling tired or having little energy, poor appetite or overeating, and having little interest in doing things with all-cause and CVD mortality but not ischemic heart disease mortality.
"Taken together with the body of literature on associations between depression and CVD mortality, these findings can support public health efforts to develop a comprehensive, nationwide strategy to improve well-being, including both mental and cardiovascular health," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted October 2023
Read this next
Perinatal Suicide Tied to Intimate Partner Problems, Depression, Substance Use
WEDNESDAY, July 3, 2024 -- Perinatal suicide is often associated with intimate partner problems (IPPs) and behavioral health issues, according to a study published online...
High Social Media Use Tied to Depression in Only Some Teens
TUESDAY, July 2, 2024 -- High social media use is only tied to increased depression in teens who are already vulnerable, according to a study published online June 26 in...
Small Differences in Weight Change With First-Line Antidepressants
MONDAY, July 1, 2024 -- For eight first-line antidepressants, small differences are seen in mean weight change, with the least weight gain with bupropion, according to a study...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.