GERD Can Induce Occurrence of Rheumatoid Arthritis, but Not Vice Versa
By Elana Gotkine HealthDay Reporter
WEDNESDAY, Jan. 31, 2024 -- Gastroesophageal reflux disease (GERD) causally and positively influences rheumatoid arthritis (RA), but RA has no significant influence on GERD, according to a study published online Dec. 13 in Frontiers in Genetics.
Haifan Wang, from The Second Affiliated Hospital of Xi'an Jiaotong University in China, and colleagues examined the bidirectional causal effects between GERD and RA by two-sample Mendelian randomization (MR) analyses using genetic evidence for 129,080 GERD cases versus 602,604 controls and 6,236 RA cases and 147,221 controls. The primary analysis used an inverse-variance weighted method.
The researchers found valid evidence provided by both univariate (UV)MR and multivariate (MV)MR analyses that RA was causally and positively influenced by GERD (odds ratios, 1.49 and 1.69 for UVMR and MVMR, respectively), but RA did not influence GERD.
"The results suggested that GERD can induce the occurrence of RA, whereas RA has no significant impact on GERD," the authors write. "In particular, individuals with GERD are at a 69 percent higher risk of developing RA, highlighting GERD as a significant risk factor for this condition."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
![](/img/logo/vendor/healthday-logo.png)
© 2024 HealthDay. All rights reserved.
Posted January 2024
Read this next
Socioeconomic Factors Linked to Persistently Active Rheumatoid Arthritis
MONDAY, July 22, 2024 -- Socioeconomic factors and deprivation are associated with persistently active rheumatoid arthritis (pactiveRA), according to a study published online July...
Odds of IBS, Functional Dyspepsia Increased After Acute Gastroenteritis Episode
WEDNESDAY, July 17, 2024 -- A considerable proportion of individuals experiencing acute gastroenteritis develop postinfection irritable bowel syndrome (PI-IBS) and postinfection...
Improved GERD Questionnaire Scores Seen With Antireflux Mucosectomy
WEDNESDAY, July 3, 2024 -- For patients with refractory gastroesophageal reflux disease (GERD), those receiving antireflux mucosectomy (ARMS) have a greater improvement in the...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.