Dapivirine Vaginal Ring Safe, Effective at Preventing HIV During Pregnancy
By Lori Solomon HealthDay Reporter
THURSDAY, March 14, 2024 -- Adverse pregnancy outcomes related to use of the dapivirine vaginal ring (DVR) or daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) during the second trimester are uncommon, according to a study presented at the annual Conference on Retroviruses and Opportunistic Infections, held from March 3 to 6 in Denver.
Felix Mhlanga, M.B.Ch.B., from the University of Zimbabwe in Harare, and colleagues presented results from the third cohort of women initiating the DVR product during the second trimester of pregnancy as part of a phase 3b study. The analysis included healthy, HIV-uninfected pregnant women (ages 18 to 40 years) from South Africa, Uganda, Zimbabwe, and Malawi who were randomly assigned (4:1) to monthly DVR (202 participants) or TDF/FTC (49 participants).
The researchers noted two stillbirths and one miscarriage. Most deliveries were at term (96 percent), and pregnancy complications were uncommon. In three cases in the DVR arm, preterm premature rupture of membranes occurred. Overall, 11 infant participants had congenital anomalies (most commonly umbilical hernias), none of which was related to the study product. No HIV infections occurred in this cohort of women.
"These data, combined with the data from cohorts 1 and 2 and the safety data from women who used the DVR at the time of conception, support using DVR and TDF/FTC as HIV prevention options for pregnant people at risk of HIV," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted March 2024
Read this next
Multivitamin Use Not Linked to Mortality Benefit in U.S. Adults
WEDNESDAY, June 26, 2024 -- Multivitamin (MV) use is not associated with mortality benefit among U.S. adults, according to a study published online June 26 in JAMA Network...
COVID-19 Vaccination Not Tied to Adverse Pregnancy Outcomes
TUESDAY, June 25, 2024 -- mRNA COVID-19 vaccination during pregnancy is not associated with an increased risk of adverse pregnancy outcomes, according to a study published in the...
Mailed HIV Self-Tests Can Improve Access to Testing in Priority Audiences
THURSDAY, June 20, 2024 -- Mailed HIV-self tests (HIVSTs) can increase testing among persons who have never received testing for HIV or have not received testing in the past year...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.