Could Sulthiame, a Pill Approved in Europe for Epilepsy, Help Ease Sleep Apnea?
By Dennis Thompson HealthDay Reporter
TUESDAY, Sept. 10, 2024 -- A European epilepsy drug could be an effective treatment for sleep apnea, a new study suggests.
Patients who took sulthiame had few pauses in their breathing while asleep, as well as higher levels of blood oxygen, according to clinical trial results presented Tuesday at the European Respiratory Society annual meeting in Vienna.
“This suggests that sulthiame could be an effective treatment for obstructive sleep apnea, especially for those who find they cannot use the existing mechanical treatments” like a CPAP machine, said researcher Jan Hedner from Sahlgrenska University Hospital and the University of Gothenburg in Sweden.
Sulthiame has never been approved for use in the United States, but it is used in Europe to treat epilepsy. It appears to quell seizures by increasing blood levels of an established anticonvulsant called phenytoin.
The drug also targets the respiratory system by inhibiting an enzyme called carbonic anhydrase, which stimulates upper airway muscles, researchers explained.
For the study, researchers recruited nearly 300 people being treated for sleep apnea at hospitals in Spain, France, Belgium, Germany and the Czech Republic. None of the patients were using CPAP machines or mouthpieces to keep their airways open during sleep.
Three-fourths of the participants were prescribed sulthiame at different dosage levels, and the remaining quarter took a placebo pill.
Those taking the highest dose of sulthiame had 40% to 50% better breathing at night than those on placebo, based on different measures of sleep apnea, researchers said.
Sulthaime patients also felt less sleepy during the daytime, researchers said.
The drug produced mild to moderate side effects like pins and needles, headache, fatigue and nausea.
“People taking sulthiame in the trial had a reduction in obstructive sleep apnea symptoms such as stopping breathing during the night and feeling sleepy during the day,” Hedner said in a meeting news release. “Their average levels of oxygen in the blood were also improved with the treatment.”
However, Hedner said further clinical trials are needed to confirm these benefits before sulthaime can be widely adopted as a treatment for sleep apnea.
Head of the ERS meeting, Sophia Schiza, noted this is one of the first studies to suggest that a drug could help with sleep apnea. Schiza was not involved in the research.
“The results are promising,” Schiza, a professor of respiratory and sleep medicine at the University of Crete in Greece, said in a news release. “We need to continue testing sulthiame and other treatments to understand their long-term effects, including any side effects.”
Because these findings were presented at a medical meeting, they should be considered preliminary until published in a peer-reviewed journal.
Sources
- European Respiratory Society, news release, Sept. 10, 2024
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted September 2024
Read this next
Scientists Track Brain Function as Folks Watch Movies
WEDNESDAY, Nov. 6, 2024 -- A person’s brain performs an intricate juggling act while watching a movie, a new study demonstrates. Scans showed that 24 different brain...
Abortion Rights Measures Pass in 7 States, Fail in 3
WEDNESDAY, Nov. 6, 2024 -- In election results that showed protecting women's reproductive freedoms matter to a majority of Americans, abortion rights measures passed in seven...
Little More Learning Might Not Save Your Aging Brain
WEDNESDAY, Nov. 6, 2024 -- In 1972, Britain bumped up the total school years mandated for its children from 15 to 16 years. That created a "natural experiment": Would Britons who...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.