CMR-Modeled PCWP Independent Risk Factor for Heart Failure
By Elana Gotkine HealthDay Reporter
THURSDAY, Aug. 22, 2024 -- Elevated cardiovascular magnetic resonance (CMR) imaging-modeled pulmonary capillary wedge pressure (PCWP) is an independent risk factor for heart failure and major adverse cardiovascular events (MACE), according to a study published online Aug. 12 in ESC Heart Failure.
Ross J. Thomson, B.M.B.Ch., from Queen Mary University of London, and colleagues examined the prognostic value of CMR-modeled PCWP at the population level using data from the imaging substudy of the U.K. Biobank. A model incorporating left atrial volume, left ventricular mass, and sex was used to calculate CMR-modeled PCWP. The relationship between typical cardiovascular risk factors and elevated CMR-modeled PCWP (≥15 mmHg) was explored. The impact of typical risk factors and CMR-modeled PCWP was examined on heart failure and MACE.
The study included data from 39,163 participants (median age, 64 years). The researchers found that hypertension (odds ratio [OR], 1.57), body mass index (OR, 1.57 per standard deviation increment), male sex (OR, 1.37), age (OR, 1.33 per decade increment), and regular alcohol consumption (OR, 1.10) were clinical characteristics independently associated with elevated CMR-modeled PCWP. Independent, significant associations were seen for CMR-modeled PCWP with incident heart failure and MACE after adjustment for potential confounders.
"These findings may have implications for developing targeted screening strategies at the population level for heart failure," the authors write.
Several authors disclosed ties to the medical device and technology industries.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted August 2024
Read this next
Empagliflozin Has Kidney Protective Effects in Acute Myocardial Infarction
THURSDAY, June 26, 2025 -- Empagliflozin has kidney protective effects and reduces heart failure outcomes across baseline kidney function among patients with acute myocardial...
CT Perfusion and CT Angiography Not Useful as Standalone Tests for Establishing Death by Neurologic Criteria
THURDAY, June 26, 2025 -- Neither computed tomography (CT) perfusion nor CT angiography meet the prespecified validation threshold as an ancillary test for death by neurologic...
Quality Improvement Initiative Ups Adherence to Medical Therapy for Heart Failure
MONDAY, June 23, 2025 -- For patients with heart failure, hospital participation in the IMPLEMENT-HF initiative improves adherence to quadruple medication therapy (QMT), defined...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.