Chemo Tied to Gut Microbiome Changes and Associated Cognitive Decline
By Lori Solomon HealthDay Reporter
TUESDAY, July 23, 2024 -- Gut microbiome change is associated with cognitive decline during chemotherapy for patients with breast cancer, according to a study published online in the August issue of Brain, Behavior, and Immunity.
Lauren D. Otto-Dobos, Ph.D., from the Institute for Behavioral Medicine Research at The Ohio State University in Columbus, and colleagues analyzed fecal samples, blood samples, and cognitive measures from 77 patients with breast cancer before, during, and after chemotherapy.
The researchers found that chemotherapy altered the gut microbiome community structure and increased circulating tumor necrosis factor-alpha (TNF-α). The chemotherapy-induced changes in microbial relative abundance and decreased microbial diversity both were associated with elevated circulating pro-inflammatory cytokines TNF-α and interleukin-6. Participant-reported subjective cognitive decline during chemotherapy was not associated with changes in the gut microbiome or inflammatory markers. However, a decrease in overall objective cognition was associated with a decrease in microbial diversity, independent of circulating cytokines. Compared to individuals without cognitive decline, those with cognitive decline (35 percent) had unique taxonomic shifts in Faecalibacterium, Bacteroides, Fusicatenibacter, Erysipelotrichaceae UCG-003, and Subdoligranulum over the course of chemotherapy treatment.
"These results suggest that microbiome-related strategies may be useful for predicting and preventing behavioral side effects of chemotherapy," the authors write.
One author disclosed ties to Scioto Biosciences.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted July 2024
Read this next
Coffee Linked to Higher Cognitive Performance in Seniors With A-Fib
THURSDAY, Dec. 26, 2024 -- For elderly patients with atrial fibrillation, regular coffee consumption is associated with higher cognitive performance, according to a study...
Disparities Seen in Biennial Mammography Screening for Women in in Their 40s
MONDAY, Dec. 23, 2024 -- For women aged 40 to 49 years, there are considerable disparities and gaps in biennial mammography screening, according to a research letter published...
Cannabidiol Safe, May Lower Anxiety in Advanced Breast Cancer
FRIDAY, Dec. 20, 2024 -- For patients with advanced breast cancer and baseline clinical anxiety, cannabidiol (CBD) is safe and may reduce anxiety levels two to four hours after...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.