Breast Cancer May Spread Faster at Night
Medically reviewed by Drugs.com. Last updated on July 7, 2024.
THURSDAY, June 23, 2022 -- When breast cancer patients sleep, tumor cells may "awaken" and spread through the bloodstream, a surprising study out of Switzerland reveals.
Circulating cancer cells that later form new growths (metastases) do not arise continuously as previously assumed, according to researchers at ETH Zurich, the University Hospital Basel and the University of Basel.
"When the affected person is asleep, the tumor awakens," said study leader Nicola Aceto, a professor of molecular oncology at ETH Zurich.
Lead study author Zoi Diamantopoulou, a postdoctoral researcher at ETH Zurich, added, "Our research shows that the escape of circulating cancer cells from the original tumor is controlled by hormones such as melatonin, which determine our rhythms of day and night."
About 2.3 million people worldwide develop breast cancer each year. When their cancers are detected early, patients usually respond well to treatment, the authors noted. But treatment is more difficult if a cancer spreads, which occurs when cells break away from the original tumor and travel through the blood vessels to other spots in the body.
The new study included 30 breast cancer patients and mouse models.
The researchers discovered that tumors generate more circulating cells when the host is asleep.
Cells that leave the tumor at night also divide more quickly and thus have a higher potential to form new tumors than circulating cells that leave the original tumor during the day.
As such, the time of day when tumor or blood samples are collected for diagnosis may also influence findings. This was discovered by accident when colleagues worked unusual hours, Aceto said in an ETH Zurich news release.
Another clue about the impact of sleep was the surprisingly high number of cancer cells found per unit of blood in mice compared to humans, the researchers noted. As nocturnal animals, mice sleep during the day, which is when scientists collect most of their samples.
"In our view, these findings may indicate the need for health care professionals to systematically record the time at which they perform biopsies," Aceto said. "It may help to make the data truly comparable."
The researchers next need to figure out how these findings can be used to get the most from existing cancer treatments.
Aceto also wants to investigate whether different cancers behave like breast cancer and whether existing therapies can be made more successful if patients are treated at different times.
The findings were published June 22 in Nature.
Sources
- ETH Zurich, news release, June 22, 2022
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted June 2022
Read this next
Too Many Breast Cancer Survivors Miss Out on Genetic Screening
FRIDAY, July 19, 2024 -- Many breast cancer patients aren’t getting genetic counseling and testing that could help them get the most effective treatment, a new study...
Irregular Sleep Could Raise Your Odds for Diabetes
WEDNESDAY, July 17, 2024 (HeathDay News) -- Sleeping long hours one night but only a few hours the next can be unhealthy, with a new study finding "irregular" sleep patterns could...
Are You & Your Partner in a 'Sleep Divorce?' You're Not Alone
WEDNESDAY, July 17, 2024 -- Many couples may be painfully familiar with the scenario: One partner snores loudly all night long, so the other partner seeks better sleep in another...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.
