Bidirectional Link ID'd for Autoimmune Disease, Perinatal Depression
By Elana Gotkine HealthDay Reporter
FRIDAY, Jan. 19, 2024 -- There is a bidirectional association between autoimmune disease (AD) and perinatal depression (PND), according to a study published online Jan. 9 in Molecular Psychiatry.
Emma Bränn, from the Karolinska Institutet in Stockholm, and colleagues examined the bidirectional association between PND and AD using nationwide Swedish population and health registers. A total of 55,299 incident PND cases were included, as well as their unaffected full sisters, and 10 unaffected matched women per PND case. Forty-one subtypes of AD diagnoses were identified from the registers.
The researchers found that women with an AD had an increased risk for subsequent PND (odds ratio, 1.30), and women exposed to PND had an increased risk for subsequent AD (odds ratio, 1.30). Comparing exposed women with their unaffected sisters yielded comparable associations (nested case-control odds ratio, 1.3; matched cohort hazard ratio, 1.3); associations were also comparable when studying antepartum and postpartum depression. Women without psychiatric comorbidities had a more pronounced bidirectional association (nested case-control odds ratio, 1.5; matched cohort hazard ratio, 1.4), with the strongest association seen for multiple sclerosis (nested case-control odds ratio, 2.0; matched cohort hazard ratio, 1.8).
"These findings have implications for research on biological mechanisms, and for health care professionals who need to be alert to the risk of PND in women with AD, and vice versa," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
![](/img/logo/vendor/healthday-logo.png)
© 2024 HealthDay. All rights reserved.
Posted January 2024
Read this next
High Social Media Use Tied to Depression in Only Some Teens
TUESDAY, July 2, 2024 -- High social media use is only tied to increased depression in teens who are already vulnerable, according to a study published online June 26 in...
Small Differences in Weight Change With First-Line Antidepressants
MONDAY, July 1, 2024 -- For eight first-line antidepressants, small differences are seen in mean weight change, with the least weight gain with bupropion, according to a study...
Social Anxiety Tied to Later Risk for Suicidal Ideation, Depression
FRIDAY, June 21, 2024 -- Baseline social anxiety symptoms are associated with two-year suicidal ideation and depressive symptoms, according to a study published online June 10...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.