Sotorasib

Generic name: sotorasib
Brand name: Lumakras
Dosage form: oral tablet (120 mg; 240 mg; 320 mg)
Drug class: Miscellaneous antineoplastics

Medically reviewed by Drugs.com on Mar 3, 2025. Written by Cerner Multum.

What is sotorasib?

Sotorasib is used alone or with other medications to treat non-small cell lung cancer or colon or rectal cancer in adults.

Sotorasib is used when the cancer has spread to other parts of the body, cannot be removed with surgery, and after other treatments did not work or stopped working.

Your doctor will make sure you have the correct tumor type to be treated with sotorasib.

Sotorasib may also be used for purposes not listed in this medication guide.

Sotorasib side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Sotorasib may cause breathing problems that could lead to death. Get emergency medical help if you have new or worsening fever, cough, or shortness of breath.

Sotorasib may cause serious side effects. Call your doctor at once if you have:

• severe ongoing nausea, vomiting, or diarrhea;

• unusual bleeding--bruising, any bleeding that will not stop; or

• liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of sotorasib may include:

• dry skin, skin rash;

• mouth sores;

• nausea, diarrhea;

• cough;

• muscle or bone pain;

• tiredness; or

• abnormal blood tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

Tell your doctor if you have or have ever had:

• liver disease; or

• lung or breathing problems other than lung cancer.

It is not known if sotorasib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while taking sotorasib, and for at least 1 week after your last dose.

How should I take sotorasib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Your doctor will perform tests to make sure sotorasib is the right treatment for you.

You may take sotorasib with or without food, but take it the same way each time.

Sotorasib is usually taken once per day and may be used in combination with other cancer treatments. Follow your doctor's instructions.

Swallow the tablet whole and do not crush, chew, or break it.

Read and carefully follow the instructions provided with this medicine on how to prepare and take sotorasib if you cannot swallow tablets whole. Ask your doctor or pharmacist if you don't understand these instructions.  

If you vomit shortly after taking sotorasib, do not take another dose. Take your next dose as scheduled.

You may be given other medications to help prevent serious side effects or allergic reaction. Keep taking these medicines for as long as your doctor has prescribed.

Your blood will need to be tested often and you may need medical tests to check your liver function. Your dose or medication schedule may be reduced, delayed, or permanently discontinued based on the results.

Store at room temperature away from moisture and heat.

Sotorasib dosing information

Usual Adult Dose for Non-Small Cell Lung Cancer:

960 mg orally once a day
Duration of therapy: Until disease progression or unacceptable toxicity

Comments:
-This indication is approved under accelerated approval based on overall response rate and duration of response; continued approval may depend on verification and description of clinical benefit in confirmatory trial(s).

Use: For the treatment of patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC), as determined by an FDA-approved test, who have received at least 1 prior systemic therapy

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if you are more than 6 hours late for the dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking sotorasib?

Ask your doctor before taking an antacid and take only the type your doctor recommends.

What other drugs will affect sotorasib?

If you take an antacid (such as Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, or Tums), take your sotorasib dose 4 hours before or 10 hours after taking the antacid. Use only the type of antacid your doctor recommends.

Avoid taking an antacid, such as:

• cimetidine, famotidine, nizatidine, ranitidine, Pepcid, Tagamet, Zantac; or

• dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Prilosec, Protonix, and others.

Other drugs may affect sotorasib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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