Netupitant and palonosetron

Generic name: netupitant and palonosetron (oral) [ net-UE-pi-tant-and-PAL-oh-NOE-se-tron ]
Brand name: Akynzeo
Dosage form: oral capsule (300 mg-0.5 mg)
Drug class: Miscellaneous antiemetics

Medically reviewed by Drugs.com on Jun 3, 2024. Written by Cerner Multum.

What is netupitant and palonosetron?

Netupitant and palonosetron is used with other medications to prevent nausea and vomiting that may happen during and after chemotherapy in adults.

Netupitant and palonosetron is not used to treat nausea and vomiting that you already have.

Netupitant and palonosetron may also be used for purposes not listed in this medication guide.

Netupitant and palonosetron side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects of netupitant and palonosetron may include:

• headache;

• feeling weak or tired;

• skin redness; or

• upset stomach, constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

ondansetron, lorazepam, dexamethasone, Zofran, metoclopramide, Ativan

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

Tell your doctor if you have ever had:

• an allergic reaction to a similar medicine for nausea or vomiting, such as dolasetron, ondansetron, palonosetron, or granisetron; or

• severe liver or kidney disease.

Tell your doctor if you also use stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with netupitant and palonosetron could cause a serious condition called serotonin syndrome.

Netupitant and palonosetron may harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using netupitant and palonosetron.

How should I take netupitant and palonosetron?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may take netupitant and palonosetron with or without food 1 hour before the start of chemotherapy.

You may be given other medications to further help prevent nausea and vomiting. Keep taking these medicines for as long as your doctor has prescribed.

You may need blood tests after receiving netupitant and palonosetron if you also take a blood thinner called warfarin.

Store at room temperature away from moisture and heat.

Netupitant and palonosetron dosing information

Usual Adult Dose for Nausea/Vomiting -- Chemotherapy Induced:

Netupitant 300 mg-palonosetron 0.5 mg orally ONCE, given 60 minutes before chemotherapy on Day 1

ADDITIONAL MEDICATIONS:
Highly Emetogenic Cancer Chemotherapy, Including Cisplatin-Based Chemotherapy:
-Day 1: Dexamethasone 12 mg orally 30 minutes prior to chemotherapy
-Days 2 to 4: Dexamethasone 8 mg orally once a day

Anthracyclines and Cyclophosphamide-Based Chemotherapy and Chemotherapy Not Considered Highly Emetogenic:
-Day 1: Dexamethasone 12 mg orally 30 minutes prior to chemotherapy

Use: In combination with dexamethasone for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy, including, but not limited to, highly emetogenic chemotherapy

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking netupitant and palonosetron?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect netupitant and palonosetron?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Many drugs can affect netupitant and palonosetron. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all other medicines you use.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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