Generic name: diazepam nasal [ dye-AZ-e-pam ]
Brand name: Valtoco
Dosage form: nasal spray (10 mg/dose; 15 mg/dose; 20 mg/dose; 5 mg/dose)
Drug classes: Benzodiazepine anticonvulsants, Benzodiazepines

Medically reviewed by Drugs.com on Oct 9, 2024. Written by Cerner Multum.

What is diazepam nasal?

Diazepam nasal is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) that is used to treat seizure clusters in adults and children at least 6 years old.

Diazepam nasal may also be used for purposes not listed in this medication guide.

Diazepam nasal side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Diazepam can slow or stop your breathing, especially if you have recently used an opioid medication or alcohol. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if the person receiving diazepam nasal has:

• extreme weakness or drowsiness;

• unusual changes in mood or behavior;

• new or worsening symptoms of depression or anxiety;

• thoughts of suicide or hurting yourself;

• sleep problems; or

• new or worsening seizures.

Drowsiness or dizziness may last longer in older adults. Use caution to avoid falling or accidental injury.

Common side effects of diazepam nasal may include:

• drowsiness;

• headache; or

• discomfort in your nose.

After you stop using diazepam, get medical help right away if you have symptoms such as: unusual muscle movements, being more active or talkative, sudden and severe changes in mood or behavior, confusion, hallucinations, seizures, suicidal thoughts or actions.

Some withdrawal symptoms may last up to 12 months or longer after stopping this medicine suddenly. Tell your doctor if you have ongoing anxiety, depression, problems with memory or thinking, trouble sleeping, ringing in your ears, a burning or prickly feeling, or a crawling sensation under your skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Diazepam can slow or stop your breathing, especially if you have recently used an opioid medication or alcohol.

MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Do not stop using diazepam without asking your doctor. You may have life-threatening withdrawal symptoms if you stop using the medicine suddenly. Some withdrawal symptoms may last up to 12 months or longer.

Get medical help right away if you stop using diazepam and have symptoms such as: unusual muscle movements, being more active or talkative, sudden and severe changes in mood or behavior, confusion, hallucinations, seizures, or thoughts about suicide.

Some people have thoughts about suicide while using diazepam nasal. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.

Before taking this medicine

You should not use diazepam nasal if you are allergic to diazepam (Valium), or if you have:

• narrow-angle glaucoma.

Diazepam nasal is not approved for use by anyone younger than 6 years old.

Tell your doctor if you have ever had:

• glaucoma;

• asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;

• liver or kidney disease;

• a drug or alcohol addiction; or

• depression, a mood disorder, or suicidal thoughts or behavior.

Some people have thoughts about suicide while using diazepam nasal. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

May harm an unborn baby. Tell your doctor if you are pregnant. If you use diazepam during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of diazepam on the baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

How should I use diazepam nasal?

This medicine is for use only in the nose.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Never use diazepam in larger amounts, or for longer than prescribed.

Never share this medicine with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Diazepam is a nasal spray that comes in a ready-to-use bottle. Each bottle is for one use only, but you may need to use more than 1 bottle to get your full dose. Follow your doctor's dosing instructions very carefully.

Keep this medicine with you at all times. Be sure a responsible family member or caregiver knows where the medicine is and how to give it to you.

After giving diazepam nasal to another person:

• note the time the diazepam dose was given;

• keep the person lying on his or her side;

• stay with the person and watch for changes in his or her seizures.

Seek emergency medical help if the person's seizure seems different or last longer than other seizures.

If needed, a second dose of diazepam nasal may be given at least 4 hours after the first dose. Do not give a second dose if the person has extreme drowsiness or very slow breathing.

Doses are based on weight. Your dose may change if you gain or lose weight.

Do not use more than 2 doses to treat a single seizure cluster episode.

Do not use diazepam nasal for more than 1 seizure cluster every 5 days. Do not use for more than 5 seizure clusters in 1 month.

Do not stop using diazepam without asking your doctor. You may have increased seizures or life-threatening withdrawal symptoms if you stop using the medicine suddenly.

Store at room temperature away from moisture, heat, and light. Do not freeze. Keep your medicine in a place where no one can use it improperly.

Related/similar drugs

gabapentin, acetaminophen, tramadol, duloxetine, escitalopram, alprazolam, cyclobenzaprine, clonazepam, lamotrigine, naproxen

What happens if I miss a dose?

Since diazepam nasal is used when needed, it does not have a daily dosing schedule. Call your doctor if your symptoms do not improve after using diazepam nasal.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diazepam can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing.

Overdose symptoms may include drowsiness, confusion, muscle weakness, or loss of consciousness.

What should I avoid while using diazepam nasal?

Avoid drinking alcohol. Dangerous side effects could occur.

Avoid driving or hazardous activity until you know how diazepam nasal will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

What other drugs will affect diazepam nasal?

Using diazepam nasal with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Other drugs may affect diazepam, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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