Adapalene and benzoyl peroxide (topical)

Generic name: adapalene and benzoyl peroxide (topical) [ a-DAP-a-leen-and-BEN-zoyl-per-OX-ide ]
Brand names: Epiduo, Epiduo Forte, Epiduo Pump
Dosage form: topical gel (0.1%-2.5%; 0.3%-2.5%)
Drug class: Topical acne agents

Medically reviewed by Drugs.com on May 9, 2024. Written by Cerner Multum.

What is adapalene and benzoyl peroxide topical?

Adapalene and benzoyl peroxide topical (for the skin) is a combination medicine used to treat acne in people 12 years and older.

Adapalene and benzoyl peroxide topical may also be used for purposes not listed in this medication guide.

Adapalene and benzoyl peroxide topical side effects

Benzoyl peroxide can cause a rare but serious allergic reaction or severe skin irritation. Stop using adapalene and benzoyl peroxide and get emergency medical help if you have: hives, itching; difficult breathing, feeling light-headed; or swelling of your face, lips, tongue, or throat.

Adapalene and benzoyl peroxide may cause serious side effects. Call your doctor at once if you have:

• severe redness or swelling of treated skin;

• severe burning or stinging; or

• severe dryness or other skin irritation.

Common side effects of adapalene and benzoyl peroxide may include:

• dry or scaly skin;

• skin redness; or

• burning or stinging.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use adapalene and benzoyl peroxide topical if you are allergic to it.

Tell your doctor if you have ever had:

• other skin problems, including cuts, abrasions, sunburn, or eczema.

Tell your doctor if you are pregnant or plan to become pregnant or breastfeeding or plan to breastfeed.

If you breastfeed, avoid applying adapalene and benzoyl peroxide to your nipple area.

How should I use adapalene and benzoyl peroxide topical?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Adapalene and benzoyl peroxide topical is usually applied once a day. Follow your doctor's instructions.

Wash your hands before and after applying this medicine.

Clean and pat dry the skin to be treated. Use a pea-sized amount of the gel for each treatment area (chin, forehead, and each cheek). Apply the medicine in a thin layer and rub in gently and allow it to dry completely before dressing.

Call your doctor if your symptoms do not improve, or if they get worse while using this medicine.

Do not apply any other skin products unless your doctor has told you to.

Store at room temperature away from moisture, heat, and light.

Adapalene and benzoyl peroxide dosing information

Usual Adult Dose for Acne:

Usual dose: Apply a thin layer to the affected area once a day

Comments:
-The affected area should be thoroughly washed and dried before application.
-A pea-sized amount should be used for each area of the face (e.g., forehead, chin, each cheek).

Use: Topical treatment of acne vulgaris

Usual Pediatric Dose for Acne:

Adapalene 0.1%/Benzoyl Peroxide 2.5% Gel
9 years and older:
-Usual dose: Apply a thin layer to the affected area once a day

Comments:
-The affected area should be thoroughly washed and dried before application.
-A pea-sized amount should be used for each area of the face (e.g., forehead, chin, each cheek).

Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel
12 years and older:
-Usual dose: Apply a thin layer to the affected area once a day

Comments:
-The affected area should be thoroughly washed and dried before application.
-A pea-sized amount should be used for each area of the face (e.g., forehead, chin, each cheek).

Use: Topical treatment of acne vulgaris

Related/similar drugs

doxycycline, clindamycin topical, erythromycin topical, tetracycline, Tazorac

What happens if I miss a dose?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medicine.

What should I avoid while using adapalene and benzoyl peroxide topical?

Avoid getting adapalene and benzoyl peroxide in your eyes, mouth, or vagina. This medicine is for use only on the skin. Do not use on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. Also avoid using adapalene and benzoyl peroxide topical on wounds or on areas of eczema.

Adapalene and benzoyl peroxide topical could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Avoid using skin products that can cause irritation, such as harsh soaps or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.

What other drugs will affect adapalene and benzoyl peroxide topical?

Medicine used on the skin is not likely to be affected by other drugs you use, but many drugs can interact. Tell your doctor about all your current medicines, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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