Adagrasib

Generic name: adagrasib
Brand name: Krazati
Dosage form: oral tablet (200 mg)
Drug class: Miscellaneous antineoplastics

Medically reviewed by Drugs.com on Feb 25, 2025. Written by Cerner Multum.

What is adagrasib?

Adagrasib is used in adults to treat non-small cell lung cancer.

Adagrasib is also used in adults to treat colorectal cancer.

Adagrasib is used when the cancer has spread to other parts of the body (metastatic), or cannot be removed by surgery.

Adagrasib can be used alone or in combination with other cancer drugs.

Adagrasib is sometimes given after other cancer treatments did not work or have stopped working.

Your doctor may perform a biopsy to test your cancer for a specific genetic marker (an abnormal "KRAS G12C" gene).

Adagrasib may also be used for purposes not listed in this medication guide.

Adagrasib side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Adagrasib may cause serious side effects. Call your doctor at once if you have:

• nausea, diarrhea, or vomiting;

• lung disease, or breathing problems;

• cough or fever;

• bowel obstruction, colitis, severe constipation;

• fast or pounding heartbeats, fluttering in your chest, and sudden dizziness (like you might pass out);

• stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or

• liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects of adagrasib may include:

• anemia (low red blood cells);

• nausea, diarrhea, vomiting;

• skin rash, dry skin;

• dizziness, tiredness;

• muscle and bone pain;

• cough, trouble breathing;

• severe numbness or tingling in your arms or legs;

• stomach pain, constipation, loss of appetite; or

• swelling, urinating less, feeling tired or short of breath.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

Tell your doctor if you have ever had:

• heart problems, including heart failure and congenital long QT syndrome; or

• liver problems.

It is not known if adagrasib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Adagrasib may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using adagrasib.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

How should I take adagrasib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take adagrasib twice a day with or without food, at the same time each day.

Do not change your dose or stop using this medication without your doctor's advice.

Swallow the tablet whole and do not crush, chew, or break it.

If you vomit shortly after taking adagrasib, do not take another dose. Take your next dose as scheduled.

You may be given medication to prevent nausea or vomiting while you are receiving adagrasib.

Your treatment may be changed or permanently discontinued if you have certain side effects.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using adagrasib.

You will need medical tests before and during treatment with adagrasib.

You may need medical tests to check your heart function and electrolytes.

Store at room temperature away from moisture and heat.

Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

Adagrasib dosing information

Usual Adult Dose for Non-Small Cell Lung Cancer:

600 mg orally twice daily

Duration of therapy: Until disease progression or unacceptable toxicity.

Comments:
-Administer this drug at the same time every day, with or without food.
-If a dose of this drug is missed by more than 4 hours, skip the dose and resume dosing at the next scheduled time.
-In case of vomiting after taking a dose, do not take another dose. Resume dosing at the next scheduled time.

Use: For the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC), who received at least one prior treatment for their cancer.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if you are more than 4 hours late for the dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking adagrasib?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect adagrasib?

Adagrasib can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Other drugs may affect adagrasib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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