Brand names: Rifadin, Rimactane
Drug class: Antituberculosis Agents

Medically reviewed by Drugs.com on Jun 10, 2024. Written by ASHP.

Introduction

Antibacterial and antimycobacterial agent; semisynthetic derivative of rifamycin SV.¹⁶¹

Uses for Rifampin

Tuberculosis

Treatment of active (clinical) tuberculosis (TB) in conjunction with other antituberculosis agents.^{176 203 258 r v} IV rifampin is designated an orphan drug by FDA for this use.¹⁷⁸

First-line agent for treatment of all forms of active TB caused by Mycobacterium tuberculosis known or presumed to be susceptible to the drug.^{176 258 r v} Essential component of multiple-drug regimens used in the initial intensive treatment phase and the continuation treatment phase.^{176 258 r v}

Fixed-combination preparation containing rifampin and isoniazid (Rifamate) is used for treatment of pulmonary TB.^{258 259} Isoniazid and rifampin are both used in the initial intensive treatment phase and the continuation treatment phase,²⁵⁸ but manufacturer states that Rifamate is not recommended for initial therapy and the fixed-combination preparation should be used only after the patient has been treated with the individual components and efficacy of these drugs has been established.²⁵⁹

Fixed-combination preparation containing rifampin, isoniazid, and pyrazinamide (Rifater) is used for treatment of pulmonary TB;^{172 258} designated an orphan drug by FDA for this use.¹⁷⁸ Used only in the initial intensive treatment phase since pyrazinamide is not usually indicated for the continuation phase.^{172 258}

For initial treatment of active TB caused by drug-susceptible M. tuberculosis, recommended multiple-drug regimens consist of an initial intensive phase (2 months) and a continuation phase (4 or 7 months).^{176 258} Although the usual duration of treatment for drug-susceptible pulmonary and extrapulmonary TB (except disseminated infections and TB meningitis) is 6–9 months,^{176 258} ATS, CDC, and IDSA state that completion of treatment is determined more accurately by the total number of doses and should not be based solely on the duration of therapy.²⁵⁸ A longer duration of treatment (e.g., 12–24 months) usually is necessary for infections caused by drug-resistant M. tuberculosis.^{176 258}

Patients with treatment failure or drug-resistant M. tuberculosis, including multidrug-resistant (MDR) TB (resistant to both isoniazid and rifampin) or extensively drug-resistant (XDR) TB (resistant to both isoniazid and rifampin and also resistant to a fluoroquinolone and at least one parenteral second-line antimycobacterial such as capreomycin, kanamycin, or amikacin), should be referred to or managed in consultation with experts in the treatment of TB as identified by local or state health departments or CDC.^{258 x}

Latent Tuberculosis Infection

Treatment of latent tuberculosis infection (LTBI).^{176 177 194 215 225 269 t u v}

LTBI is asymptomatic infection with M. tuberculosis; usually defined as a positive tuberculin skin test (TST) or Quantiferon-TB gold test (QFT-G) with no evidence of active (clinical) TB.^{176 194 215 225 269 u v} LTBI is treated to decrease the risk of progression to active TB.^{194 215 t u}

Regimen of choice for treatment of LTBI is isoniazid monotherapy, unless the patient has been in contact with an individual with drug-resistant TB.^{176 177 194 215 225 269 t v} Rifampin monotherapy is the preferred alternative and is especially useful in adults, adolescents, or children who have been exposed to isoniazid-resistant M. tuberculosis and those who cannot tolerate isoniazid.^{176 177 194 215 269} Rifabutin is used in those who cannot receive rifampin because of intolerance or because they are receiving other drugs that have clinically important interactions with rifampin (e.g., HIV patients receiving certain antiretroviral agents).^{101 177 194 215 225 269 v}

Although 2-drug regimens of rifampin and pyrazinamide were previously used for treatment of LTBI,^{176 177 194 215 t v} these regimens have been associated with an increased risk of hepatotoxicity and are no longer recommended for treatment of LTBI.^{257 269 t v} (See Hepatic Effects under Cautions.)

Treatment of LTBI in patients who have been exposed to a source case with drug-resistant TB, including MDR TB or XDR TB, should be managed in consultation with experts in the treatment of TB as identified by local or state health departments or CDC.^{176 215 269 t u v}

Prior to initiating treatment of LTBI, clinical (active) TB must be excluded using appropriate testing (e.g., radiographs).^{176 177 194 215 225 269 t v}

Anthrax

Has been used in conjunction with other anti-infectives for treatment of inhalational anthrax^{† [off-label]} following bioterrorism-related anthrax exposures.^{252 253}

Multiple-drug parenteral regimens are recommended for treatment of inhalational anthrax that occurs as the result of exposure to Bacillus anthracis spores in the context of biologic warfare or bioterrorism.^{139 252 254} Initiate treatment with IV ciprofloxacin or doxycycline and 1 or 2 other anti-infectives predicted to be effective (e.g., chloramphenicol, clindamycin, rifampin, vancomycin, clarithromycin, imipenem, penicillin, ampicillin);^{252 253 254} if meningitis is established or suspected, use IV ciprofloxacin (rather than doxycycline) and chloramphenicol, rifampin, or penicillin.²⁵⁴

Bartonella Infections

Treatment of infections caused by Bartonella henselae^{† [off-label]} (e.g., cat scratch disease, bacillary angiomatosis, peliosis hepatitis).^{176 203 233 234 235}

Cat scratch disease generally self-limited in immunocompetent individuals and may resolve in 2–4 months; some clinicians suggest that anti-infective therapy be considered for acutely or severely ill patients with systemic manifestations, particularly those with hepatosplenomegaly or painful lymphadenopathy, and such therapy probably is indicated in immunocompromised patients. ^{176 233 236 237 238} Anti-infectives also indicated in patients with B. henselae infections who develop bacillary angiomatosis, neuroretinitis, or Parinaud's oculoglandular syndrome.^{236 237 238} Optimum regimens have not been identified; some clinicians recommend erythromycin, azithromycin, doxycycline, ciprofloxacin, rifampin, co-trimoxazole, or gentamicin.^{176 203 236 237 238}

Brucellosis

Treatment of brucellosis^{† [off-label]} caused by Brucella melitensis.^{176 203 227 228 229 230 270} Used as an adjunct to other anti-infectives.^{176 203 227 228 229 230 270} Tetracyclines generally considered the drugs of choice; concomitant use of another anti-infective (e.g., streptomycin or gentamicin and/or rifampin) is recommended to reduce the likelihood of relapse, especially for severe infections and when there are complications such as meningitis, endocarditis, or osteomyelitis.^{176 203 227 228 229 230 270} Also has been used as an adjunct to co-trimoxazole or quinolones (ciprofloxacin, ofloxacin).^{176 203 227 228 229 230 270} Monotherapy is not recommended.^{176 270}

Postexposure prophylaxis following a high-risk exposure to Brucella ^{† [off-label]} (e.g., percutaneous or mucous membrane exposure or aerosolization of infectious material in the laboratory or livestock husbandry setting, exposure in the context of biologic warfare or bioterrorism).^{139 176} Postexposure prophylaxis not generally recommended after exposure to endemic brucellosis.^{139 176} Regimens recommended for postexposure prophylaxis are the same as those recommended for treatment of brucellosis.¹³⁹

Ehrlichiosis and Anaplasmosis

Alternative for treatment of human granulocytotropic anaplasmosis^{† [off-label]} (HGA; formerly human granulocytic ehrlichiosis) caused by Anaplasma phagocytophilum (formerly Ehrlichia phagocytophila).^{203 241 k} Doxycycline is usual drug of choice for anaplasmosis;^{176 203 241 k} rifampin can be used for mild illness due to HGA in those who cannot receive doxycycline (e.g., children <8 years of age, pregnant women).^k

Rifampin is ineffective for treatment of Lyme disease; patients receiving rifampin for treatment of HGA who are coinfected with B. burgdorferi should receive amoxicillin or cefuroxime for treatment of Lyme disease.^k

Legionella Infections

Treatment of infections caused by Legionella pneumophila^† (Legionnaires’ disease); used as an adjunct to a macrolide (e.g., azithromycin, erythromycin), a fluoroquinolone (e.g., ciprofloxacin, ofloxacin, levofloxacin), or a tetracycline (e.g., doxycycline).^{146 166 176 203 226 232}

Leprosy

Treatment of leprosy^† in conjunction with other anti-infectives.^{176 198 199 203 205 206 207 jj}

WHO and others recommend rifampin-based multiple-drug regimens (ROM) for treatment of all forms of leprosy, including multibacillary leprosy^† (>5 skin lesions), paucibacillary leprosy^† (2–5 lesions), and single-lesion paucibacillary leprosy^† (single skin lesion with definite loss of sensation but without nerve trunk involvement).^{176 198 199 201 202 203 204 205 206 207 jj}

Because rifampin is bactericidal against M. leprae, it is the principal component of multiple-drug regimens used for treatment of leprosy;^{198 199 200 201 207 jj} other drugs are included in the regimens to prevent emergence of rifampin-resistant M. leprae.^{198 199 206 207 jj}

Treatment of leprosy is complicated and should be undertaken in consultation with a specialist familiar with the disease (e.g., clinicians at the National Hansen's Disease Program at 800-642-2477 or ).^{176 kk}

Mycobacterium avium Complex (MAC) Infections

Treatment of M. avium complex (MAC) pulmonary infections^† in conjunction with other antimycobacterials.^{176 191}

For initial treatment of nodular/bronchiectatic pulmonary disease caused by macrolide-susceptible MAC, ATS and IDSA recommend a 3-times weekly regimen of clarithromycin (or azithromycin), ethambutol, and rifampin in most patients.¹⁹¹ For initial treatment of fibrocavitary or severe nodular/bronchiectatic pulmonary disease caused by macrolide-susceptible MAC, ATS and IDSA recommend a daily regimen of clarithromycin (or azithromycin), ethambutol, and rifampin (or rifabutin) and state that consideration can be given to adding amikacin or streptomycin during the first 2–3 months of treatment for extensive (especially fibrocavitary) disease or when previous therapy has failed.¹⁹¹

Although either rifampin or rifabutin can be used in multiple-drug regimens for treatment of MAC infections, rifampin may be the preferred rifamycin for most patients with pulmonary MAC infections since it may be better tolerated (e.g., in older patients).¹⁹¹ Rifabutin may be the preferred rifamycin for treatment of disseminated MAC disease (especially in HIV-infected patients) since it appears to be more active in vitro against MAC and is associated with fewer drug interactions.^{176 191 r s} Rifampin is not included in current ATS, CDC, NIH, and IDSA guidelines for treatment of disseminated MAC infections in HIV-infected individuals.^{191 r s}

Treatment of MAC infections is complicated and should be directed by clinicians familiar with mycobacterial diseases; consultation with a specialist is particularly important when the patient cannot tolerate first-line drugs or when the infection has not responded to prior therapy or is caused by macrolide-resistant MAC.¹⁹¹ In addition, specialized references should be consulted for guidance on the use of rifamycins in HIV-infected patients receiving antiretroviral agents.¹⁹¹ (See Specific Drugs and Tests under Interactions.)

Mycobacterium kansasii and Other Mycobacterial Infections

Treatment of M. kansasii^† infections in conjunction with other antimycobacterials.^{176 191 203} ATS and IDSA recommend a regimen of isoniazid, rifampin, and ethambutol for treatment of pulmonary or disseminated infections caused by rifampin-susceptible M. kansasii.¹⁹¹ If rifampin-resistant M. kansasii are involved, ATS and IDSA recommend a 3-drug regimen based on results of in vitro susceptibility testing, including clarithromycin (or azithromycin), moxifloxacin, ethambutol, sulfamethoxazole, or streptomycin.¹⁹¹

Treatment of M. marinum^† infections in conjunction with other antimycobacterials (e.g., ethambutol with or without clarithromycin).^{176 191 203 bb cc ff} Optimum regimens not identified.^{191 bb cc ff} Monotherapy (minocycline, clarithromycin, doxycycline, co-trimoxazole) may be effective for superficial cutaneous infections,^bb but a multiple-drug regimen usually used for severe cutaneous infections or infections in immunocompromised individuals.^{bb cc}

Treatment of M. ulcerans^† infections with or without other antimycobacterials.^{176 191} ATS and IDSA state that preulcerative lesions can be effectively treated by excision and primary closure, rifampin monotherapy, or heat therapy.¹⁹¹ Surgical debridement with skin grafting usually is the treatment of choice for M. ulcerans infections since antimycobacterials generally are ineffective.¹⁹¹ However, postsurgical antimycobacterials may prevent relapse or metastasis of infections and a regimen of clarithromycin and rifampin is recommended to control complications of M. ulcerans ulcers.¹⁹¹

Treatment of infections caused by M. xenopi^† in conjunction with other antimycobacterials.¹⁹¹ Optimum regimens not established; in vivo response may not correlate with in vitro susceptibility.¹⁹¹ ATS and IDSA state that a regimen of clarithromycin, rifampin, and ethambutol generally has been used, although rate of relapse is high.¹⁹¹ A regimen of isoniazid, rifampin (or rifabutin), ethambutol, and clarithromycin (with or without streptomycin during initial treatment) also has been suggested.¹⁹¹

Neisseria meningitidis Infections

Prophylaxis to prevent meningococcal disease in household or other close contacts of individuals with invasive meningococcal disease^† when the risk of infection is high.^{176 179 187 266} Recommended regimens for such prophylaxis are rifampin (not recommended in pregnant women), ceftriaxone, or ciprofloxacin (not recommended in individuals <18 years of age unless no other regimen can be used and not recommended for pregnant or lactating women).^{176 187} AAP considers rifampin the drug of choice in most pediatric patients.¹⁷⁶

Elimination of nasopharyngeal carriage of Neisseria meningitidis.^{161 163 176 179 187 266} CDC and AAP recommend rifampin, ceftriaxone, or ciprofloxacin for such carriers.^{176 179 187} Manufacturers state rifampin should not be used indiscriminately and should be used only when the risk of meningococcal meningitis is high.^{161 163 176 179}

Should not be used for treatment of meningococcal infections; rapid emergence of resistant strains may occur during long-term therapy.^{161 163 266}

Rhodococcus Infections

Treatment of infections caused by Rhodococcus equi ^†; used in conjunction with vancomycin.²⁰³ Optimum regimens have not been identified; combination regimens usually are recommended, including vancomycin given with a fluoroquinolone, rifampin, a carbapenem (imipenem or meropenem), or amikacin.^{203 239 240}

Staphylococcal and Streptococcal Infections

Treatment of serious infections (bacteremia, pneumonia, and meningitis) caused by penicillin-resistant Streptococcus pneumoniae ^† or oxacillin-resistant Staphylococcus aureus or S. epidermidis ^† (previously known as methicillin-resistant S. aureus or S. epidermidis) in conjunction with other anti-infectives (e.g., third generation cephalosporins, vancomycin).^{176 203 226} Rifampin should not be used alone in the treatment of staphylococcal or streptococcal infections.^{176 203}

Prevention of Haemophilus influenzae Type b Infection

Chemoprophylaxis in contacts of patients with Haemophilus influenzae type b (Hib) infection^†.^{102 103 104 105 106 134 135 138 140 141 176} Considered the most effective anti-infective for eradicating carriage of Hib.^{102 103 104 105 106 134 138 141} AAP and ACIP state rifampin is the drug of choice for chemoprophylaxis in contacts of patients with Hib infection.^{134 135 141 145 176}

In household contacts of patients with Hib infection, AAP recommends prophylaxis for all household contacts (except pregnant women), irrespective of age, in those households with at least one contact <48 months of age who is incompletely vaccinated against Hib, those households with an immunocompromised child (even if the child is >48 months of age), and those households where there is a child <12 months of age, irrespective of the vaccination status of the child.¹⁷⁶

In child-care and nursery school contacts of patients with Hib infection, AAP recommends prophylaxis for all attendees (regardless of age) if ≥2 cases of invasive disease have occurred within 60 days and there are unvaccinated or incompletely vaccinated children attending the facility.¹⁷⁶ If a single case has occurred, the advisability of rifampin prophylaxis in exposed child-care groups with unimmunized or incompletely immunized children is controversial, but many experts recommend no prophylaxis.¹⁷⁶

Rifampin Dosage and Administration

Administration

Administer orally.¹⁶¹ May be given by IV infusion if oral therapy is not feasible.^{161 b} Should not be given IM or sub-Q.^{161 b}

Used in conjunction with other anti-infectives for treatment of active (clinical) TB, anthrax, brucellosis, legionella infections, leprosy, MAC or other mycobacterial infections, rhodococcus infections, and staphylococcal and streptococcal infections.^{127 146 176 161 166 176 191 198 200 203 204 206 207 226 227 229 230 232 258}

Fixed-combination preparations (Rifamate containing rifampin and isoniazid; Rifater containing rifampin, isoniazid, and pyrazinamide) can be used for treatment of active TB infection to reduce the pill burden and ensure compliance, especially when directly observed (supervised) therapy (DOT) cannot be used.²⁵⁸ A fixed-combination preparation should be used only when all drugs in the preparation are indicated.²⁵⁸

Oral Administration

Administer single-entity rifampin or fixed-combination preparations (Rifamate , Rifater) orally with a full glass of water 1 hour before or 2 hours after a meal.^{161 172 259}

For individuals who are unable to swallow rifampin capsules and when lower doses are needed for children, a 1% suspension can be prepared using Syrup NF (simple syrup), Syrpalta syrup (Emerson Laboratories), or Raspberry syrup (HumCo Laboratories).¹⁶¹ To prepare a suspension containing rifampin 10 mg/mL, empty the contents of four 300-mg or eight 150-mg capsules and mix the contents vigorously with 20 mL of a recommended syrup; then further dilute with 100 mL of the syrup.¹⁶¹ Shake well prior to administration.¹⁶¹

An oral liquid formulation of rifampin containing 25 mg/mL also has been extemporaneously compounded using the capsules and a commercially available vehicle.⁹⁸

Standardize 4 Safety

Standardized concentrations for an extemporaneously prepared oral liquid formulation of rifampin have been established through Standardize 4 Safety (S4S), a national patient safety initiative to reduce medication errors, especially during transitions of care.⁹⁹ Because recommendations from the S4S panels may differ from the manufacturer’s prescribing information, caution is advised when using concentrations that differ from labeling, particularly when using rate information from the label.⁹⁹ For additional information on S4S (including updates that may be available), see [Web].⁹⁹

IV Administration

Administer by IV infusion.^{161 b}

Avoid extravasation.^{161 b} Discontinue infusion and restart at another site if local irritation and inflammation occur at the site of infusion.^{161 b}

Reconstitution and Dilution

Reconstitute vial containing 600 mg of rifampin powder by adding 10 mL sterile water for injection and gently swirling the vial.^{161 b} Reconstituted solution contains 60 mg/mL.^{161 b}

Prior to administration, add the appropriate dose of reconstituted solution to 100 or 500 mL of 5% dextrose injection or 0.9% sodium chloride injection.^{161 b}

Rate of Administration

If infusion volume is 100 mL, give IV at a rate that allows complete infusion within 30 minutes.^{161 b}

If infusion volume is 500 mL, give IV at a rate that allows complete infusion within 3 hours.^{161 b}

Dosage

Oral and IV dosages are the same.¹⁶¹

Dosage of Rifamate expressed as number of capsules;²⁵⁹ dosage of Rifater expressed as number of tablets.¹⁷²

Pediatric Patients

General Dosage for Infants and Children

Oral or IV

Children ≥1 month of age: AAP recommends 10–20 mg/kg (up to 600 mg) daily given in 1 or 2 divided doses for mild to moderate infections or 20 mg/kg (up to 600 mg) daily in 2 divided doses for severe infections.¹⁷⁶

Tuberculosis

Treatment of Active (Clinical) Tuberculosis

Oral

Children <15 years of age or weighing ≤40 kg: 10–20 mg/kg (up to 600 mg) daily recommended by manufacturer, ATS, CDC, IDSA, AAP, and others.^{161 176 258 s v} If an intermittent regimen is used, 10–20 mg/kg (up to 600 mg) 2 or 3 times weekly.^{176 258 s v}

Adolescents ≥15 years of age: 10 mg/kg (up to 600 mg) daily.^{258 v} If an intermittent regimen is used, 10 mg/kg (up to 600 mg) 2 or 3 times weekly.^{258 v}

Rifater in adolescents ≥15 years of age: 4 tablets once daily in those weighing ≤44 kg, 5 tablets once daily in those weighing 45–54 kg, or 6 tablets once daily in those weighing ≥55 kg.¹⁷² Used only in the initial phase of treatment.¹⁷²

When used for the treatment of active TB in HIV-infected individuals with CD4⁺ T-cell counts <100/mm³, rifampin should be given at least 3 times weekly.^{101 r} CDC and others recommend these patients receive a once-daily regimen during the initial intensive treatment phase and either a once-daily or 3-times weekly regimen during the continuation phase.^{100 r}

IV

10–20 mg/kg (up to 600 mg) daily.^{161 b v}

Latent Tuberculosis Infection (LTBI)

Oral

10–20 mg/kg (up to 600 mg) once daily for 4–6 months.^{176 177 194 215 269 v} If daily regimen cannot be used, AAP states 10–20 mg/kg (up to 600 mg) twice weekly for 6 months can be administered using directly observed (supervised) therapy (DOT) .¹⁷⁶

ATS and CDC recommend that completion of therapy for LTBI be based on total number of administered doses rather duration of therapy alone.^{194 215} When rifampin monotherapy is used, at least 120 doses should be administered within 6 months.²¹⁵ Ideally, patients should receive the drug on a regular dosing schedule until completed; in practice, some doses may be missed requiring the course to be lengthened.²¹⁵ If the regimen is resumed after an interruption of ≥2 months, a medical examination is indicated to rule out active TB.^{194 215}

Brucellosis†

Treatment or Prevention†

Oral

15–20 mg/kg (up to 600–900 mg) daily; given in conjunction with other anti-infectives.¹⁷⁶

For postexposure prophylaxis, continue for 3–6 weeks;¹³⁹ for treatment, continue for 4–6 weeks (more prolonged therapy may be needed in serious infections or when there are complications).^{139 176}

Ehrlichiosis and Anaplasmosis†

Mild Anaplasmosis†

Oral

10 mg/kg (up to 300 mg) twice daily for 7–10 days.^k

Leprosy†

Multibacillary Leprosy†

Oral

Children <10 years of age: 300 mg once monthly in conjunction with dapsone (25 mg once daily) and clofazimine (50 mg twice weekly and 100 mg once monthly).²⁰⁴

Children 10–14 years of age: 450 mg once monthly in conjunction with dapsone (50 mg once daily) and clofazimine (50 mg every other day and 150 mg once monthly).^{204 jj}

Usual duration of treatment is 12 months.^{198 200 206 207 jj} An additional 12 months of treatment may be necessary in some patients (e.g., those with a high baseline bacterial index who have no evidence of improvement or have evidence of deterioration after the initial 12 months of treatment).^jj

Paucibacillary Leprosy†

Oral

Children <10 years of age: 300 mg once monthly in conjunction with dapsone (25 mg once daily).²⁰⁴

Children 10–14 years of age: 450 mg once monthly in conjunction with dapsone (50 mg once daily).^{204 jj}

Usual duration of treatment is 6 months.^{204 jj}

Single-lesion Paucibacillary Leprosy†

Oral

Children 5–14 years of age: A single 300-mg dose of rifampin in conjunction with a single dose of ofloxacin (200 mg) and a single dose of minocycline (50 mg).²⁰⁴

Children <5 years of age: Use an appropriately adjusted dose of each drug in the above single-dose regimen.²⁰⁴

Neisseria meningitidis Infections

Prophylaxis in Household or Other Close Contacts†

Oral

Neonates <1 month of age: 5 mg/kg every 12 hours for 2 days.^{176 179 187}

Children ≥1 month of age: 10 mg/kg (up to 600 mg) every 12 hours for 2 days.^{176 179 187}

Initiate as soon as possible after contact, preferably within 24 hours after identification of the index case.^{176 179 187}

Elimination of Pharyngeal Carrier State

Oral

Neonates <1 month of age: 5 mg/kg every 12 hours for 2 days.¹⁶¹

Children ≥1 month of age: 10 mg/kg (up to 600 mg) every 12 hours for 2 days.¹⁶¹

Staphylococcal and Streptococcal Infections†

Meningitis Caused by S. pneumoniae †

IV

Children ≥1 month of age: 20 mg/kg daily given in divided doses every 12 hours; used as an adjunct to other anti-infectives (e.g., vancomycin).¹⁷⁶

Prevention of Haemophilus influenzae Type b Infection†

Oral

Neonates <1 month of age: Some clinicians recommend 10 mg/kg once daily for 4 consecutive days.^{134 176}

Children ≥1 month of age: 20 mg/kg (up to 600 mg) once daily for 4 consecutive days.^{134 138 176}

Adults

Tuberculosis

Treatment of Active (Clinical) Tuberculosis

Oral

10 mg/kg (up to 600 mg) once daily recommended by the manufacturers, ATS, CDC, IDSA, and others.^{161 258 r v} If an intermittent regimen is used, 10 mg/kg (up to 600 mg daily) 2 or 3 times weekly.^{258 v}

Rifamate: 2 capsules once daily.²⁵⁹

Rifater: 4 tablets once daily in adults weighing ≤44 kg, 5 tablets once daily in adults weighing 45–54 kg, or 6 tablets once daily in adults weighing ≥55 kg.¹⁷² Used only in the initial phase of treatment.¹⁷²

When used for the treatment of active TB in HIV-infected individuals with CD4⁺ T-cell counts <100/mm³, rifampin should be given at least 3 times weekly.^r CDC and others recommend these patients receive a once-daily regimen during the initial intensive phase and either a once-daily or 3-times weekly regimen during the continuation phase.^{100 r}

IV

10 mg/kg (up to 600 mg) once daily.¹⁶¹

Latent Tuberculosis Infection (LTBI)

Oral

10 mg/kg (up to 600 mg) once daily for 4 months.^{177 194 215 v}

ATS and CDC recommend that completion of therapy for LTBI be based on total number of administered doses rather duration of therapy alone.^{194 215} When rifampin monotherapy is used, at least 120 doses should be administered within 6 months.²¹⁵ Ideally, patients should receive the drug on a regular dosing schedule until completed; in practice, some doses may be missed requiring the course to be lengthened.²¹⁵ If the regimen is resumed after an interruption of ≥2 months, a medical examination is indicated to rule out active TB.^{194 215}

Anthrax†

Inhalational Anthrax†

IV

300 mg every 12 hours has been used in conjunction with other anti-infectives.¹²⁷

Anthrax Meningitis†

IV

20 mg/kg daily in conjunction with other anti-infectives.¹³⁹

Brucellosis†

Oral

15–20 mg/kg (up to 600–900 mg) daily in conjunction with other anti-infectives.^{139 176 227 229 230} Some clinicians suggest 0.6–1.2 g daily in conjunction with other anti-infectives.²⁷⁰

For postexposure prophylaxis, continue for 3–6 weeks; ¹³⁹ for treatment, continue for 4–6 weeks (more prolonged therapy may be needed in serious infections or when there are complications).^{139 176} Some clinicians state that 6–8 weeks of treatment may be necessary in patients with skeletal disease and ≥3 months (and possibly >6 months) of treatment may be necessary in those with meningoencephalitis or endocarditis.¹³⁹

Ehrlichiosis and Anaplasmosis†

Mild Anaplasmosis†

Oral

300 mg twice daily for 7–10 days.^k

Leprosy†

Multibacillary Leprosy†

Oral

600 mg once monthly in conjunction with dapsone (100 mg once daily) and clofazimine (50 mg once daily and 300 mg once monthly).^{198 200 204 206 207 jj}

Usual duration of treatment is 12 months.^{198 200 206 207 jj} An additional 12 months of treatment may be necessary in some patients (e.g., those with a high baseline bacterial index who have no evidence of improvement or have evidence of deterioration after the initial 12 months of treatment).^jj

Paucibacillary Leprosy†

Oral

600 mg once monthly in conjunction with dapsone (100 mg once daily).^{198 200 204 206 207 jj}

Usual duration of treatment is 6 months.^{198 200 204 206 207 jj}

Single-lesion Paucibacillary Leprosy†

Oral

A single 600-mg dose of rifampin in conjunction with a single dose of ofloxacin (400 mg) and a single dose of minocycline (100 mg).^{204 jj}

Mycobacterium avium Complex (MAC) Infections†

Initial Treatment of Pulmonary MAC Infections (Nodular/bronchiectatic Disease) Caused by Macrolide-susceptible Strains†

Oral

600 mg 3 times weekly in conjunction with ethambutol (25 mg/kg 3 times weekly) and either clarithromycin (1 g 3 times weekly) or azithromycin (500 mg 3 times weekly) recommended by ATS and IDSA.¹⁹¹ Continue until patient has been culture negative on treatment for 1 year.¹⁹¹

Intermittent (3-times weekly) regimen is not recommended for those with cavitary or moderate or severe disease or those who have been previously treated.¹⁹¹

Initial Treatment of Pulmonary MAC Infections (Fibrocavitary or Severe Nodular/bronchiectatic Disease) Caused by Macrolide-susceptible Strains†

Oral

10 mg/kg (up to 600 mg) once daily in conjunction with ethambutol (15 mg/kg once daily) and either clarithromycin (0.5–1 g daily) or azithromycin (250 mg once daily) recommended by ATS and IDSA.¹⁹¹ Continue until patient has been culture negative on treatment for 1 year.¹⁹¹ Consideration can be given to including amikacin or streptomycin 3 times weekly during the first 2–3 months of treatment for extensive, especially fibrocavitary, disease or when previous therapy has failed.¹⁹¹

Mycobacterium kansasii and Other Mycobacterial Infections†

Treatment of Pulmonary or Disseminated Infections Caused by Rifampin-susceptible M. kansasii†

Oral

10 mg/kg (up to 600 mg) daily in conjunction with ethambutol (15 mg/kg once daily), isoniazid (5 mg/kg [up to 300 mg] daily), and pyridoxine (50 mg daily) recommended by ATS and IDSA.¹⁹¹

Continue until patient has been culture negative on treatment for 1 year.¹⁹¹ A longer duration may be needed in HIV-infected individuals with disseminated infections.¹⁹¹

Treatment of M. marinum Infections†

Oral

600 mg daily^{bb ff} in conjunction with ethambutol (15–25 mg/kg daily).^{bb ff}

Optimal duration of treatment not known; continue for 3–6 months or until at least 1–2 months after resolution of symptoms.^{191 bb cc ff}

Neisseria meningitidis Infections

Prophylaxis in Household or Other Close Contacts†

Oral

600 mg every 12 hours for 2 days.¹⁸⁷

Initiate as soon as possible after contact, preferably within 24 hours after identification of the index case.^{176 179 187}

Elimination of Pharyngeal Carrier State

Oral or IV

600 mg twice daily for 2 days.^{161 b}

Prevention of Haemophilus influenzae Type b Infection†

Oral

20 mg/kg (up to 600 mg) once daily for 4 consecutive days.^{134 138 176}

Prescribing Limits

Pediatric Patients

Tuberculosis

Active (Clinical) Tuberculosis

Oral or IV

Maximum 600 mg per dose in once-daily or 2- or 3-times weekly regimens.^{161 176 258 269 s v}

Latent Tuberculosis Infection (LTBI)

Oral or IV

Maximum 600 mg per dose in once-daily or twice-weekly regimens.^{161 176 258 269 s v}

Brucellosis

Oral

Maximum 600–900 mg daily.¹⁷⁶

Ehrlichiosis and Anaplasmosis†

Mild Anaplasmosis†

Oral

Maximum 300 mg twice daily.¹⁷⁶

Neisseria meningitidis Infections

Prophylaxis or Elimination of Pharyngeal Carrier State

Oral

Children ≥1 month of age: Maximum 600 mg every 12 hours.¹⁶¹

Prevention of Haemophilus influenzae Type b Infection

Oral

Maximum 600 mg once daily.^{134 138 176}

Adults

Tuberculosis

Active (Clinical) Tuberculosis

Oral or IV

Maximum 600 mg per dose in once-daily or 2- or 3-times weekly regimens.^{161 215 258 v}

Latent Tuberculosis Infection (LTBI)

Oral or IV

Maximum 600 mg once daily.^{161 215 258 v}

Brucellosis

Oral

Maximum 600–900 mg daily.^{139 227 229 230}

Mycobacterium avium Complex (MAC) Infections†

Initial Treatment of Pulmonary MAC Infections (Fibrocavitary or Severe Nodular/bronchiectatic Disease) Caused by Macrolide-susceptible Strains†

Oral

Maximum 600 mg once daily.^{139 227 229 230}

Mycobacterium kansasii and Other Mycobacterial Infections†

Treatment of Pulmonary or Disseminated Infections Caused by Rifampin-susceptible M. kansasii†

Oral

Maximum 600 mg daily.^{139 227 229 230}

Special Populations

Renal Impairment

Dosage adjustment not required in renal impairment or end-stage renal disease if dosage is ≤600 mg daily.^{161 258}

Cautions for Rifampin

Contraindications

• Known hypersensitivity to rifampin or other rifamycins (rifabutin, rifapentine).¹⁶¹

Warnings/Precautions

Warnings

Hepatic Effects

Hepatic dysfunction reported.¹⁶¹ Fatalities associated with jaundice reported in patients with preexisting liver disease or receiving other hepatotoxic agents.¹⁶¹ Discontinue if signs of hepatocellular damage occur.¹⁶¹ (See Hepatic Impairment under Cautions.)

Hyperbilirubinemia (resulting from competition between rifampin and bilirubin for excretory pathways in the liver) can occur shortly after initiation of rifampin therapy.¹⁶¹ An isolated report of a moderate increase in bilirubin and/or transaminase concentrations is not an indication to interrupt rifampin therapy; the decision to discontinue the drug should be made after repeating the tests, noting trends in the concentrations, and considering the patient’s clinical condition.¹⁶¹

Transient abnormalities in liver function tests (e.g., elevated serum bilirubin, alkaline phosphatase, serum transaminases) and reduced biliary excretion of contrast media used for visualization of the gallbladder reported; the gallbladder test should be performed prior to the morning dose of rifampin.¹⁶¹

Severe liver injuries, including some fatalities, have been reported in patients receiving a 2-drug regimen of pyrazinamide and rifampin (once daily for 2 months) for the treatment of LTBI.^{177 222 225 257} A 2-drug regimen of rifampin and pyrazinamide should be considered for treatment of LTBI only in carefully selected patients with close monitoring and only if potential benefits outweigh the risk of hepatotoxicity and death.²⁵⁷ If a rifampin and pyrazinamide regimen is used, monitor serum aminotransferases and bilirubin concentrations at baseline and at 2, 4, 6, and 8 weeks; assess patient at 2, 4, 6 and 8 weeks for adherence, tolerance, and adverse effects.²⁵⁷ Permanently discontinue in asymptomatic patients with an aminotransferase concentration >5 times the ULN, in patients with symptoms of hepatitis who have an aminotransferase concentration >ULN, and in patients who have serum bilirubin concentrations >ULN (regardless of the presence or absence of symptoms).²⁵⁷

Patients with Porphyria

There have been isolated reports of exacerbation of porphyria in patients receiving rifampin; rifampin has enzyme-inducing properties, including induction of delta amino levulinic acid synthetase.¹⁶¹

Sensitivity Reactions

Hypersensitivity Reactions

Hypersensitivity reactions characterized by flu-like syndrome with episodes of fever, chills, and sometimes with headache, dizziness, and bone pain reported.¹¹⁵ Edema of the face and extremities, decrease in blood pressure, shock, or dyspnea (sometimes accompanied by wheezing) also reported.^{115 161}

Pruritus, urticaria, acneiform eruptions,^{154 155} rash, pemphigoid reactions, erythema multiforme including Stevens-Johnson syndrome,^{154 156 161} toxic epidermal necrolysis,¹⁶¹ vasculitis,¹⁶¹ eosinophilia, sore mouth, sore tongue,¹⁵⁴ exfoliative dermatitis,¹⁵³ and exudative conjunctivitis reported.^a Anaphylaxis reported rarely.^{154 161}

Some cutaneous reactions, including flushing and pruritus (with or without rash), are mild and self-limiting and do not appear to be hypersensitivity reactions.¹⁶¹ More serious cutaneous reactions occur less frequently and do appear to be hypersensitivity reactions.¹⁶¹

Sulfite Sensitivity

Rifampin sterile powder for injection contains sulfites, which may cause allergic-type reactions (including anaphylaxis and life-threatening or less severe asthmatic episodes) in certain susceptible individuals.^a

General Precautions

Endocrine Effects

Possible enhanced metabolism of endogenous substrates (e.g., cortisol, thyroid hormones, vitamin D) secondary to hepatic microsomal enzyme induction.^{108 161}

Decreased plasma concentrations of 25-hydroxy vitamin D (the major circulating metabolite of vitamin D) and/or 1α,25-dihydroxy vitamin D accompanied by decreased plasma calcium and phosphate concentrations and increased parathyroid hormone concentrations reported.^{161 223 b}

Discoloration of Body Fluids

Urine, sputum, sweat, or tears may have a reddish coloration.^{161 172 258 259 b} Soft contact lenses may become permanently stained.^{161 172 258 b}

Patient Monitoring

Obtain baseline measurements of liver function (hepatic enzymes, bilirubin) and hematologic status (CBC, platelet count) in adults receiving rifampin for treatment of TB; baseline tests not considered necessary in pediatric patients unless a complicating condition is known or suspected.¹⁶¹

Evaluate patient at least monthly during therapy; question patient about adverse effects.¹⁶¹ Follow up all abnormalities, including laboratory monitoring, if indicated.¹⁶¹ Routine laboratory monitoring for drug-induced toxicity generally not necessary in patients with normal baseline test results.¹⁶¹

Use of Fixed Combinations

When the fixed-combination preparations (Rifamate containing rifampin, isoniazid, and pyrazinamide or Rifater containing rifampin and isoniazid) are used, observe the usual precautions and contraindications associated with all drugs in the preparation.^{172 259} Use these preparations only when all drugs contained in the fixed combination are indicated.²⁵⁸

Selection and Use of Anti-infectives

To reduce development of drug-resistant bacteria and maintain effectiveness of rifampin and other antibacterials, use only for treatment or prevention of infections proven or strongly suspected to be caused by susceptible bacteria.¹⁶¹

When selecting or modifying anti-infective therapy, use results of culture and in vitro susceptibility testing.¹⁶¹ In the absence of such data, consider local epidemiology and susceptibility patterns when selecting anti-infectives for empiric therapy.¹⁶¹

If used to eliminate nasopharyngeal carriage of N. meningitidis or for postexposure prophylaxis to prevent meningococcal disease, a short-term rifampin regimen (e.g., 2-day regimen) should be used since resistant strains of N. meningitidis may rapidly emerge during prolonged rifampin treatment.¹⁶¹ Rifampin should be used only when the risk of meningococcal disease is high.¹⁶¹ Appropriate diagnostic laboratory procedures (e.g., serotyping, in vitro susceptibility testing) should be performed.¹⁶¹

Precautions Related to Treatment of Tuberculosis

When used for treatment of TB, there is some evidence that rifampin dosage >600 mg once daily or twice weekly is associated with a higher incidence of adverse reactions, including flu syndrome (fever, chills, malaise), hematopoietic reactions (leukopenia, thrombocytopenia, acute hemolytic anemia), cutaneous, GI, and hepatic reactions, shortness of breath, shock, anaphylaxis, and renal failure.¹⁶¹ Regimens using rifampin 600 mg twice weekly (in conjunction with isoniazid 15 mg/kg) are better tolerated.¹⁶¹

Should not be used alone for the treatment of active TB; must be used in conjunction with other antituberculosis agents.²⁵⁸

Clinical specimens for microscopic examination and mycobacterial cultures and in vitro susceptibility testing should be obtained prior to initiation of antituberculosis therapy and periodically during treatment to monitor therapeutic response.²⁵⁸ The antituberculosis regimen should be modified as needed.²⁵⁸ Patients with positive cultures after 4 months of treatment should be considered to have failed treatment (usually as the result of noncompliance or drug-resistant TB).²⁵⁸

Compliance with the full course of antituberculosis therapy and all drugs included in the multiple-drug regimen is critical.²⁵⁸ Missed doses increase the risk of treatment failure and increase the risk that M. tuberculosis will develop resistance to the antituberculosis regimen.²⁵⁸

To ensure compliance, ATS, CDC, IDSA, and AAP recommend that directly observed (supervised) therapy (DOT) be used for treatment of active (clinical) TB and for treatment of LTBI whenever possible, especially when intermittent regimens are used, when the patient is immunocompromised or infected with HIV, or when drug-resistant M. tuberculosis is involved.^{176 215 269 r s u v}

When used for the treatment of active (clinical) TB in HIV-infected individuals with CD4⁺ T-cell counts <100/mm³, once- or twice-weekly rifampin regimens are associated with an increased risk of emergence of resistant M. tuberculosis.^r CDC and others recommend these patients receive once-daily or 3-times weekly rifampin regimens.^{100 r}

Specific Populations

Pregnancy

Category C.¹⁶¹

A regimen of isoniazid, rifampin, and ethambutol is recommended by ATS, CDC, IDSA, and AAP for treatment of active TB in pregnant women.^{176 258 r}

Rifampin administration during the last few weeks of pregnancy can cause postnatal hemorrhages in the mother and infant; treat such hemorrhages with vitamin K.¹⁶¹ Some experts recommend prophylactic administration of vitamin K (10 mg) to neonates born to women who received rifampin during pregnancy.^r

Lactation

Distributed into milk.¹⁷⁶ Discontinue nursing or the drug.¹⁶¹

Pediatric Use

Used in pediatric patients for the treatment of active (clinical) TB and treatment of LTBI,^{167 169 171 176} to eliminate nasopharyngeal carriage of N. meningitidis,^{161 163 176 179 187} for chemoprophylaxis against meningococcal disease^{†176 179 187} or H. influenzae type b (Hib) infection^†,^{102 103 104 134 135 136 137 138 144 145 176} and for treatment of leprosy^†.^{198 204 206}

Rifater: Safety and efficacy not established in children <15 years of age; the ratio of rifampin and isoniazid in this preparation may not be appropriate for this age group.¹⁷²

Rifamate: Safety and efficacy not established in pediatric patients.²⁵⁹

Geriatric Use

Insufficient experience in patients ≥65 years of age to determine whether geriatric patients respond differently than younger adults.¹⁶¹ Clinical experience has not identified differences in response relative to younger adults.¹⁶¹

Use caution.¹⁶¹

Hepatic Impairment

Use in patients with impaired liver function only when clearly necessary and only under strict medical supervision; fatalities associated with jaundice reported in patients with liver disease.¹⁶¹

Monitor liver function (ALT and AST) before initiating therapy and every 2–4 weeks during therapy in patients with impaired hepatic function.¹⁶¹ Discontinue if signs of hepatocellular damage occur.¹⁶¹

Exacerbation of porphyria reported.¹⁶¹

Common Adverse Effects

GI effects (heartburn, epigastric distress, nausea, vomiting, anorexia, abdominal cramps, flatulence, diarrhea).^{161 a}

Drug Interactions

Induces certain CYP enzymes.¹⁶¹

Drugs Affecting or Metabolized by Hepatic Microsomal Enzymes

Pharmacokinetic interactions likely with drugs metabolized by CYP enzymes; increased metabolism of these drugs.¹⁶¹

Specific Drugs and Tests

Rifampin Pharmacokinetics

Absorption

Bioavailability

Well absorbed from GI tract;¹⁶¹ peak plasma concentrations achieved within 1–4 hours following oral administration.^{161 a}

Food

Absorption reduced 30% when administered with food.^{122 161}

Special Populations

Plasma concentrations of rifampin are higher and more prolonged in patients with impaired hepatic function, especially in the presence of obstructive jaundice.^a

Distribution

Extent

Distributed into most body tissues and fluids including the liver, lungs, bile, pleural fluid, prostate, seminal fluid, ascitic fluid, CSF, saliva, tears, and bone.^{a 161}

CSF concentrations in patients with inflamed meninges reported to be 10–20% of concurrent plasma concentrations.^{258 a}

Rifampin crosses the placenta and is distributed into cord blood.¹⁶¹

Distributed into milk.^a

Plasma Protein Binding

80–91%.^{161 a}

Elimination

Metabolism

Metabolized in the liver to a deacetylated derivative which possesses antibacterial activity.^{161 a} Rifampin undergoes enterohepatic circulation¹⁶¹ and is largely reabsorbed, but the metabolite is not.^a

Elimination Route

60% of an oral dose is excreted in feces via biliary elimination;^a 30% is excreted in urine as unchanged drug and active metabolite.^{161 a}

Not removed by hemodialysis or peritoneal dialysis.^a

Half-life

Adults: 3.35 hours after a single 600-mg dose or 5.08 hours after a single 900-mg dose.¹⁶¹ Following repeated doses in adults, half-life averages 2–3 hours.¹⁶¹

Children 6 months to 4.8 years of age receiving a 10-mg/kg oral dose: 2.9 hours.¹⁶¹

Children 3 months to 12.8 years of age receiving 300 mg/m² by IV infusion over 30 minutes: Half-life ranges from 1.04–3.81 hours early in therapy and 1.17–3.19 hours after 5–14 days of therapy.¹⁶¹

Special Populations

Dosage ≤600 mg daily in patients with renal failure: Half-life similar to that in those with normal renal function.¹⁶¹

Single 900-mg oral dose in patients with renal impairment: Half-life increased compared with values reported in those with normal renal function.¹⁶¹ Mean plasma half-life increased from 3.6 hours in healthy adults to 5, 7.3, or 11 hours in those with GFR of 30–50 mL/minute, those with GFR <30 mL/minute, or in anuric patients, respectively.¹⁶¹

Stability

Storage

Oral

Capsules

Avoid excessive heat; store in a dry place in tightly closed container.¹⁶¹

Rifamate: Avoid excessive heat; store in a dry place in tightly closed container.²⁵⁹

Tablets

Rifater: 15–30°C.¹⁷² Protect from excessive humidity.¹⁷²

Suspension

Extemporaneously prepared suspension containing 10 mg/mL (see Oral Administration under Dosage and Administration): Room temperature (25°C) or 2–8°C for up to 4 weeks.¹⁶¹

Parenteral

Powder for Injection

15–30°C.^b Avoid temperatures >40°C; protect from light.^{161 b}

Solutions reconstituted with sterile water for injection (60 mg/mL) are stable at room temperature for 24 hours.¹⁶¹ Solutions that have been further diluted with 5% dextrose injection are stable at room temperature for up to 4 hours; these solutions should be used within 3–4 hours.^{161 HID}

Manufacturer states that reconstituted solutions that have been further diluted with 0.9% sodium chloride are stable at room temperature for up to 24 hours;¹⁶¹ other information indicates substantial rifampin decomposition occurs in 24 hours; these solutions should be used within 3–4 hours.^HID

Actions and Spectrum

• A rifamycin structurally and pharmacologically similar to other rifamycins (rifabutin, rifapentine).

• Usually bactericidal.¹⁶¹

• Suppresses initiation of chain formation for RNA synthesis in susceptible bacteria by inhibiting DNA-dependent RNA polymerase.^{161 a}

• Spectrum of activity includes some gram-positive and -negative bacteria and some Mycobacterium.¹⁶¹

• Mycobacterium: Active in vitro against M. tuberculosis,^a M. bovis,^a M. marinum,^{a dd} M. kansasii,^a and some strains of M. fortuitum^a and M. avium complex.^a Also active against M. leprae.^a

• Gram-positive bacteria: Active against S. aureus, S. epidermidis, and Bacillus anthracis.^{161 252}

• Gram-negative bacteria: Active against N. meningitidis,¹⁶¹ H. influenzae, Brucella melitensis, and L. pneumophila.^{161 230 241} Also active against Ehrlichia canis, E. chaffeensis, and Anaplasma phagocytophilum.^l

• Natural and acquired resistance to rifampin observed in vitro and in vivo in M. tuberculosis, M. kansasii,¹⁶⁵ and N. meningitidis.^{189 190} Strains of M. leprae resistant to rifampin reported rarely.^{128 133 jj} β-lactamase production has no effect on rifampin activity.¹⁶¹

• Cross-resistance occurs between rifampin and other rifamycin derivatives (rifabutin, rifapentine).^{161 258 a} M. tuberculosis resistant to rifampin usually are resistant to both rifabutin and rifapentine; only rarely are rifampin-resistant strains susceptible to rifabutin.²⁵⁸

• M. tuberculosis resistant to both isoniazid and rifampin (MDR TB) occurs.^{w x y z} There also have been recent reports of extensively drug-resistant (XDR) TB in various parts of the world, including the US.^{w x z} XDR TB is caused by M. tuberculosis resistant to rifampin and isoniazid (multiple-drug resistant strains) that also are resistant to a fluoroquinolone and at least one parenteral second-line antimycobacterial (capreomycin, kanamycin, amikacin).^{w x z}

Advice to Patients

• Advise patients that antibacterials (including rifampin) should only be used to treat bacterial infections and not used to treat viral infections (e.g., the common cold).¹⁶¹

• Importance of completing full course of therapy, even if feeling better after a few days.¹⁶¹

• Advise patients that skipping doses or not completing the full course of therapy may decrease effectiveness and increase the likelihood that bacteria will develop resistance and will not be treatable with rifampin or other antibacterials in the future.¹⁶¹

• Advise patients that poor compliance with antituberculosis regimens can result in treatment failure and development of drug-resistant TB, which can be life-threatening and lead to other serious health risks.²⁵⁸

• Importance of taking rifampin 1 hour before or 2 hours after a meal with a full glass of water.¹⁶¹

• Advise patient that rifampin may impart a reddish color to urine, feces, sweat, sputum, and tears.^{161 172 258 259 b} Soft contact lenses may become permanently stained.^{161 172 258 b}

• Importance of informing clinicians if fever, loss of appetite, malaise, nausea, vomiting, darkened urine, yellow discoloration of the skin or eyes, or pain or swelling of the joints occurs.¹⁶¹

• Importance of informing clinicians of existing or contemplated therapy, including prescription and OTC drugs, as well as any concomitant illnesses.¹⁶¹

• Advise women that reliability of systemic hormonal contraceptives may be affected; alternative contraceptives should be considered.^{161 172}

• Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.¹⁶¹

• Importance of informing patients of other important precautionary information.¹⁶¹ (See Cautions.)

Additional Information

The American Society of Health-System Pharmacists, Inc. represents that the information provided in the accompanying monograph was formulated with a reasonable standard of care, and in conformity with professional standards in the field. Readers are advised that decisions regarding use of drugs are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and that the information contained in the monograph is provided for informational purposes only. The manufacturer’s labeling should be consulted for more detailed information. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information contained in the monograph is not a substitute for medical care.

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

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