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Gemfibrozil (Monograph)

Brand name: Lopid
Drug class: Fibric Acid Derivatives
VA class: CV350
Chemical name: 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid
Molecular formula: C15H22O3
CAS number: 25812-30-0

Medically reviewed by Drugs.com on Jul 17, 2023. Written by ASHP.

Introduction

Antilipemic agent; fibric acid derivative.2

Uses for Gemfibrozil

Prevention of Cardiovascular Events

Adjunct to dietary therapy to reduce the risk of developing CHD in patients with type IIb hyperlipoproteinemia without clinical evidence of CHD (primary prevention) who have an inadequate response to dietary management, weight loss, exercise, and drugs known to reduce LDL-cholesterol and increase HDL-cholesterol (e.g., bile acid sequestrants, niacin) and who have low HDL-cholesterol concentrations in addition to elevated LDL-cholesterol and triglycerides.1 67 68 104 105 110 127

Potential benefit unlikely to outweigh potential risks in patients with type IIa hyperlipoproteinemia and elevations of LDL-cholesterol only (because of toxicity, including malignancy, gallbladder disease, abdominal pain leading to appendectomy and other abdominal surgeries, and increased incidence of noncardiovascular and all-cause mortality, associated with the chemically and pharmacologically similar drug clofibrate [no longer commercially available in US]).1

Manufacturer states that gemfibrozil is not indicated for use in the management of patients with low HDL-cholesterol as their only lipid abnormality (isolated low HDL-cholesterol).1

Reduction of recurrent coronary events† [off-label], including death from coronary causes, MI, and stroke in men with clinical evidence of CHD who have low HDL-cholesterol and moderately elevated LDL-cholesterol concentrations.137

AHA/ACC cholesterol management guideline states that lifestyle modification is the foundation of cardiovascular risk reduction.400 If pharmacologic therapy is needed, statins are first-line drugs of choice because of their demonstrated benefits in reducing risk of atherosclerotic cardiovascular disease (ASCVD).400 Nonstatin drugs may be considered as adjunctive therapy in certain high-risk patients, but other drugs (e.g., ezetimibe) are generally recommended.400 Although fibrates have mild LDL-lowering effects, randomized controlled studies do not support their use as add-on therapy to statins.400

If fibrate therapy is necessary in a statin-treated patient, AHA/ACC states that it is safer to use fenofibrate than gemfibrozil because of lower risk of severe myopathy.400

Dyslipidemias

Adjunct to dietary therapy in the management of severe hypertriglyceridemia in patients at risk of developing pancreatitis (typically those with serum triglyceride concentrations >2000 mg/dL and elevated concentrations of VLDL-cholesterol and fasting chylomicrons) who do not respond adequately to dietary management.1

Also may be used in patients with triglyceride concentrations of 1000–2000 mg/dL who have a history of pancreatitis or of recurrent abdominal pain typical of pancreatitis;1 however, efficacy in patients with type IV hyperlipoproteinemia and triglyceride concentrations >1000 mg/dL who exhibit type V patterns subsequent to dietary or alcoholic indiscretion has not been adequately studied.1

Manufacturer states that gemfibrozil is not indicated for use in patients with type I hyperlipoproteinemia who have elevated triglyceride and chylomicron concentrations but normal VLDL-cholesterol concentrations.1

Effective in a very limited number of patients with type III hyperlipoproteinemia† [off-label]17 18 37 38 43 45 49 to decrease elevated triglyceride and cholesterol concentrations associated with this disorder.

Gemfibrozil Dosage and Administration

General

Administration

Oral Administration

Administer orally twice daily, 30 minutes before the morning and evening meals.1

Dosage

Adults

Prevention of Cardiovascular Events
Oral

600 mg twice daily.1 16 17 18 21 22 24 25 26 27 30 31 91 104 106

Monitor lipoprotein concentrations periodically.1 Discontinue therapy in patients who fail to achieve an adequate response after 3 months of therapy.1

Dyslipidemias
Oral

600 mg twice daily.1 16 17 18 21 22 24 25 26 27 30 31 91 104 106

Monitor lipoprotein concentrations periodically.1 Discontinue therapy in patients who fail to achieve an adequate response after 3 months of therapy.1

Detailed Gemfibrozil dosage information

Cautions for Gemfibrozil

Contraindications

Warnings/Precautions

Warnings

Cholelithiasis

May increase cholesterol excretion in bile,1 34 61 resulting in cholelithiasis.1 26 34 Cholecystitis and cholelithiasis reported.1 Discontinue therapy if gallbladder studies indicate the presence of gallstones.1

Musculoskeletal Effects

Use may be associated with myositis.1 Myalgia, myopathy, myasthenia, painful extremities, arthralgia, synovitis, and rhabdomyolysis reported.1 Myopathy, rhabdomyolysis, and other complications also reported in patients receiving gemfibrozil concomitantly with certain other antilipemic agents.1

Monitor creatine kinase (CK, creatine phosphokinase, CPK) concentrations in patients reporting adverse musculoskeletal effects.1 108 116 Discontinue therapy if myositis is suspected or diagnosed.1

Effect on Morbidity and Mortality

Effect on cardiovascular mortality not established.1 Because gemfibrozil is chemically, pharmacologically, and clinically similar to other fibric acid derivatives, some adverse effects of clofibrate (no longer commercially available in the US) such as increased incidence of cholelithiasis, cholecystitis requiring surgery, postcholecystectomy complications, malignancy, pancreatitis, appendectomy, gallbladder disease, and increased overall mortality may also apply to gemfibrozil,1 and the usual precautions associated with fibrate therapy should be observed.1

Cataracts

Possible subcapsular bilateral and unilateral cataracts.1

Sensitivity Reactions

Hypersensitivity Reactions

Angioedema, laryngeal edema, urticaria, rash, dermatitis, and pruritus reported.1

Major Toxicities

Hematologic Effects

Mild decreases in hemoglobin,1 2 hematocrit,1 2 38 and leukocyte counts1 2 reported; these counts usually normalize during long-term therapy.1 Severe anemia, leukopenia, thrombocytopenia, and bone marrow hypoplasia have occurred rarely; eosinophilia also reported.1

Monitor blood cell counts periodically during the first 12 months of therapy.1

General Precautions

Hepatic Effects

Possible elevations in serum concentrations of aminotransferase (i.e., AST, ALT),1 2 24 25 47 LDH,1 2 bilirubin,1 and alkaline phosphatase.1 2 15 25 47 Serum aminotransferase concentrations usually return slowly to pretreatment values following discontinuance of gemfibrozil.1 Cholestatic jaundice reported.1

Perform liver function tests periodically.1 Discontinue therapy if abnormalities persist.1

Carcinogenicity

Carcinogenicity (e.g., hepatic tumors, Leydig cell tumors) demonstrated in animals.1

Specific Populations

Pregnancy

Category C.1

Lactation

Not known if gemfibrozil is distributed into milk.1 102 Discontinue nursing or the drug.1

Pediatric Use

Safety and efficacy not established.1

Renal Impairment

Possible exacerbation of renal insufficiency in patients with baseline Scr >2 mg/dL.1 Consider use of alternative antilipemic therapy against the risks and benefits of a lower dose of gemfibrozil.1

Common Adverse Effects

GI disturbances (e.g., dyspepsia, abdominal pain, diarrhea, nausea, vomiting, constipation, acute appendicitis, gallbladder surgery), adverse CNS effects (headache, hypesthesia, paresthesias, dizziness, somnolence, peripheral neuritis, depression), fatigue, eczema, vertigo, taste perversion, blurred vision, decreased libido, impotence.1

Drug Interactions

Specific Drugs

Drug

Interaction

Comments

β-Adrenergic blocking agents

Possible increase in serum triglyceride and decreases in HDL-cholesterol concentrations30 74

Anticoagulants, oral (e.g., warfarin)

Potentiation of anticoagulant effects1 102 124

Use with caution;1 reduce anticoagulant dosage to maintain PT at desired level to prevent bleeding complications; monitor PT frequently until stabilized1

Estrogens

Potential increase in serum triglyceride concentrations73

HMG-CoA reductase inhibitors (statins)

Increased risk of adverse musculoskeletal effects (e.g., myopathy, rhabdomyolysis)1

Methyldopa

Possible decrease in HDL- and LDL-cholesterol concentrations74

Repaglinide

Increased repaglinide concentrations and half-life, resulting in enhanced and prolonged blood glucose-lowering effects;138 139 potential for severe hypoglycemia138

Do not initiate repaglinide in patients receiving gemfibrozil, and vice versa138 139

Monitor blood glucose and reduce repaglinide dosage as required if drugs already used concomitantly138

Patients receiving gemfibrozil concomitantly with repaglinide should not receive itraconazole138

Thiazide diuretics

Possible increase in total cholesterol and triglyceride concentrations74
Gemfibrozil drug interactions (more detail)

Gemfibrozil Pharmacokinetics

Absorption

Bioavailability

Rapidly and completely absorbed from the GI tract.1 2 7 76

Peak plasma concentrations occur within 1–2 hours.1 2 7 9 Plasma concentrations do not appear to correlate with therapeutic response.29 102

Food

Rate and extent of absorption increased when administered 30 minutes before meals.1

Distribution

Extent

Highest tissue concentrations observed in the liver and kidneys in animals.2

Gemfibrozil crosses the placenta;2 not known if it is distributed into milk.1 102

Plasma Protein Binding

About 95%.2

Elimination

Metabolism

Appears to be metabolized in the liver to 4 major metabolites produced via 3 metabolic pathways.2 7 102 A phenol derivative (metabolite I)2 7 is pharmacologically active.102

Elimination Route

Excreted in urine (70%) in the form of metabolites and in feces (approximately 6%).1

Half-life

1.3–1.5 hours.1 7 9 10

Stability

Storage

Oral

Tablets

20–25°C.1 Protect from light and humidity.1

Actions and Spectrum

Advice to Patients

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Gemfibrozil

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Tablets, film-coated

600 mg*

Gemfibrozil Tablets

Lopid

Pfizer

AHFS DI Essentials™. © Copyright 2024, Selected Revisions July 26, 2021. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Off-label: Use is not currently included in the labeling approved by the US Food and Drug Administration.

References

1. Parke-Davis. Lopid (gemfibrozil) tablets prescribing information. New York, NY; 2003 Oct.

2. Parke-Davis. Lopid (gemfibrozil) compendium of pharmacological and clinical studies. Morris Plains, NJ; 1982 Feb.

3. The United States pharmacopeia, 21st rev, and The national formulary, 16th ed. Rockville, MD: The United States Pharmacopeial Convention, Inc; 1985: 457.

4. Hodges RM. Gemfibrozil—a new lipid lowering agent. Proc R Soc Med. 1976; 69(Suppl 2):1-2. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864035&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/798192?dopt=AbstractPlus

5. Creger PL, Moersch GW, Neuklis WA. Structure/activity relationship of gemfibrozil (CI-719) and related compounds. Proc R Soc Med. 1976; 69(Suppl 2):3-5. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864034&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/1019152?dopt=AbstractPlus

6. Rodney G, Uhlendorf P, Maxwell RE. The hypolipidaemic effect of gemfibrozil (CI-719) in laboratory animals. Proc R Soc Med. 1976; 69(Suppl 2):6-10. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864017&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/828263?dopt=AbstractPlus

7. Okerholm RA, Keeley FJ, Peterson FE et al. The metabolism of gemfibrozil. Proc R Soc Med. 1976; 69(Suppl 2):11-4. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864041&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/828261?dopt=AbstractPlus

8. Kurtz SM, Fitzgerald JE, Fisken RA et al. Toxicological studies on gemfibrozil. Proc R Soc Med. 1976; 69(Suppl 2):15-23. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864019&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/828262?dopt=AbstractPlus

9. Smith TC. Toleration and bioavailability of gemfibrozil in healthy men. Proc R Soc Med. 1976; 69(Suppl 2):24-7. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864020&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/798193?dopt=AbstractPlus

10. Randinitis EJ, Kinkel AW, Nelson C et al. Gas chromatographic determination of gemfibrozil and its metabolites in plasma and urine. J Chromatogr. 1984; 307:210-5. http://www.ncbi.nlm.nih.gov/pubmed/6586728?dopt=AbstractPlus

11. Gray RH, de la Iglesia FA. Quantitative microscopy comparison of peroxisome proliferation by the lipid-regulating agent gemfibrozil in several species. Hepatology. 1984; 4:520-30. http://www.ncbi.nlm.nih.gov/pubmed/6586630?dopt=AbstractPlus

12. de la Iglesia FA, Lewis JE, Buchanan RA et al. Light and electron microscopy of liver in hyperlipoproteinemic patients under long-term gemfibrozil treatment. Atherosclerosis. 1982; 43:19-37. http://www.ncbi.nlm.nih.gov/pubmed/6807326?dopt=AbstractPlus

13. Maxwell RE, Nawrocki JW, Uhlendorf PD. Some comparative effects of gemfibrozil, clofibrate, benzafibrate, cholestyramine, and compactin on sterol metabolism in rats. Atherosclerosis. 1983; 48:195-203. http://www.ncbi.nlm.nih.gov/pubmed/6579963?dopt=AbstractPlus

14. Kahonen MT, Ylikahri RH. Effect of clofibrate and gemfibrozil on the activities of mitochondrial carnitine acyltransferases in rat liver. Dose-response relations. Atherosclerosis. 1979; 32:47-56. http://www.ncbi.nlm.nih.gov/pubmed/465113?dopt=AbstractPlus

15. Kesaniemi YA, Grundy SM. Influence of gemfibrozil and clofibrate on metabolism of cholesterol and plasma triglycerides in man. JAMA. 1984; 251:2241-6. http://www.ncbi.nlm.nih.gov/pubmed/6368883?dopt=AbstractPlus

16. Kaukola S, Manninen V, Malkonen M et al. Gemfibrozil in the treatment of dyslipidaemias in middle-aged survivors of myocardial infarction. Acta Med Scand. 1981; 209:69-73. http://www.ncbi.nlm.nih.gov/pubmed/7010929?dopt=AbstractPlus

17. Konttinen A, Kuisma I, Ralli R et al. The effect of gemfibrozil on serum lipids in diabetic patients. Ann Clin Res. 1979; 11:240-5. http://www.ncbi.nlm.nih.gov/pubmed/398183?dopt=AbstractPlus

18. Hoogwerf BJ, Bantle JP, Kuba K et al. Treatment of type III hyperlipoproteinemia with four different treatment regimens. Atherosclerosis. 1984; 51:251-9. http://www.ncbi.nlm.nih.gov/pubmed/6588975?dopt=AbstractPlus

19. Nye ER, Sutherland NHF, Temples WA. The treatment of hyperlipoproteinemia with gemfibrozil compared with placebo and clofibrate. N Z Med J. 1980; 92:345-9. http://www.ncbi.nlm.nih.gov/pubmed/6935550?dopt=AbstractPlus

20. Nash DT. Gemfibrozil in combination with other drugs for severe hyperlipidemia: preliminary study comprising four cases. Postgrad Med. 1983; 73:75-82. http://www.ncbi.nlm.nih.gov/pubmed/6572892?dopt=AbstractPlus

21. Pickering JE. Clinical results with gemfibrozil. Am J Cardiol. 1983; 52:39-40B.

22. Torstila I, Kaukola S, Manninen V et al. Plasma prekallikrein, kallikrein inhibitors, kininogen and lipids during gemfibrozil treatment in type II dyslipidaemia. Acta Med Scand Suppl. 1982; 668:123-9. http://www.ncbi.nlm.nih.gov/pubmed/6188330?dopt=AbstractPlus

23. Manninen V. Clinical results with gemfibrozil and background to the Helsinki Heart Study. Am J Cardiol. 1983; 52:35-8B.

24. Manninen V, Malkonen M, Eisalo A et al. Gemfibrozil in the treatment of dyslipidaemia: a 5-year follow-up study. Acta Med Scand (Suppl). 1982: 668:82-7. (IDIS 168759)

25. Samuel P. Effects of gemfibrozil on serum lipids. Am J Med. 1983; 74(Suppl 5A):23-7. http://www.ncbi.nlm.nih.gov/pubmed/6573843?dopt=AbstractPlus

26. Fenderson RW, Deutsch S, Menachemi E et al. Effect of gemfibrozil on serum lipids in man. Angiology. 1982; 33:581-93. http://www.ncbi.nlm.nih.gov/pubmed/6751166?dopt=AbstractPlus

27. Nash DT. Hyperlipoproteinemia, atherosclerosis and gemfibrozil. Angiology. 1982; 33:594-602. http://www.ncbi.nlm.nih.gov/pubmed/6957155?dopt=AbstractPlus

28. Lewis JE. Long-term use of gemfibrozil (Lopid) in the treatment of dyslipidemia. Angiology. 1982; 33:603-12. http://www.ncbi.nlm.nih.gov/pubmed/6957156?dopt=AbstractPlus

29. Jain AK, Ryan JR, LaCorte WSJ et al. Clinical evaluation of gemfibrozil, a new antilipemic agent. Clin Pharmacol Ther. 1981; 29:254-5.

30. Vega GL, Grundy SM. Gemfibrozil therapy in primary hypertriglyceridemia associated with coronary heart disease: effects on metabolism of low-density lipoproteins. JAMA. 1985; 253:2398-403. http://www.ncbi.nlm.nih.gov/pubmed/3856692?dopt=AbstractPlus

31. Borresen AL, Berg K, Dahlen G et al. The effect of gemfibrozil on human serum apolipoproteins and on serum reserve cholesterol binding capacity (SRCBC). Artery. 1981; 9:77. http://www.ncbi.nlm.nih.gov/pubmed/7018466?dopt=AbstractPlus

32. Dahlen D, Gillnas T, Borresen AL et al. Effect of gemfibrozil on serum lipid levels. Artery. 1980; 7:224-31. http://www.ncbi.nlm.nih.gov/pubmed/7008748?dopt=AbstractPlus

33. Schwandt P, Weisweiler P, Neureuther G. Serum lipoprotein lipids after gemfibrozil treatment. Artery. 1979; 5:117-24. http://www.ncbi.nlm.nih.gov/pubmed/231950?dopt=AbstractPlus

34. Hall MJ, Nelson LM, Russell RI et al. Gemfibrozil—the effect of biliary cholesterol saturation of a new lipid-lowering agent and its comparison with clofibrate. Atherosclerosis. 1981; 39:511-6. http://www.ncbi.nlm.nih.gov/pubmed/6942844?dopt=AbstractPlus

35. Baird IM, Lewis B, Hill JM. Preliminary observations on the effect of gemfibrozil on the excretion of faecal bile acids. Proc R Soc Med. 1976; 69(Suppl 2):112-4. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864021&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/1019150?dopt=AbstractPlus

36. Glueck C. Influence of gemfibrozil on high-density lipoproteins. Am J Cardiol. 1983; 52:31-4B.

37. Olsson AG, Rossner S, Walldius G et al. Effect of gemfibrozil on lipoprotein concentrations in different types of hyperlipoproteinaemia. Proc R Soc Med. 1976; 69(Suppl 2):28-31. http://www.ncbi.nlm.nih.gov/pubmed/190607?dopt=AbstractPlus

38. Vessby B, Lithell J, Boberg J et al. Gemfibrozil as a lipid lowering compound in hyperlipoproteinaemia. A placebo-controlled cross-over trial. Proc R Soc Med. 1976; 69(Suppl 2):32-7. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864027&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/798194?dopt=AbstractPlus

39. Tuomilehto J, Salonen J, Kuusisto P et al. A clofibrate controlled trial of gemfibrozil in the treatment of hyperlipidaemias. Proc R Soc Med. 1976; 69(Suppl 2):38-40.

40. Beaumont JL, Dachet C. Binding of plasma lipoproteins of chlorophenoxyisobutyric, tibric and nicotinic acids and their esters. Proc R Soc Med. 1976; 69(Suppl 2):41-3. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864029&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/1019153?dopt=AbstractPlus

41. Eisalo A, Manninen V. Gemfibrozil and clofibrate in the treatment of hyperlipidaemias: a comparative trial. Proc R Soc Med. 1976; 69(Suppl 2):47-8. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864013&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/798197?dopt=AbstractPlus

42. Eisalo A, Manninen V, Malkonen M et al. Hypolipidaemic action of gemfibrozil in adult nephrotics. Proc R Soc Med. 1976; 69(Suppl 2):47-8. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864013&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/798197?dopt=AbstractPlus

43. Eisalo A, Manninen V. A long-term trial of gemfibrozil in the treatment of hyperlipidaemias. Proc R Soc Med. 1976; 69(Suppl 2):49-52. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864023&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/798198?dopt=AbstractPlus

44. Huunan-Seppala A, Manninen V, Burton R et al. Extrinsic factors affecting the response to gemfibrozil. Proc R Soc Med. 1976; 69(Suppl 2):53-7. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864032&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/1019154?dopt=AbstractPlus

45. Nikkila EA, Ylikahri R, Huttunen JK. Gemfibrozil: effect on serum lipids, lipoproteins, post-heparin plasma lipase activities and glucose tolerance in primary hypertriglyceridaemia. Proc R Soc Med. 1976; 69(Suppl 2):58-63. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864025&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/190608?dopt=AbstractPlus

46. de Salcedo I, Gorringe JAL, Luiz Salva J et al. Gemfibrozil in a group of diabetics. Proc R Soc Med. 1976; 69(Suppl 2):64-70.

47. Lageder H, Irsigler K. Evaluation of increasing doses of gemfibrozil in hyperlipoproteinaemia. Proc R Soc Med. 1976; 69(Suppl 2):71-5. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864014&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/798199?dopt=AbstractPlus

48. Janus ED, Costa D, Ononogbu IC et al. The evaluation of lipoprotein changes during gemfibrozil treatment. Proc R Soc Med. 1976; 69(Suppl 2):76-7. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864026&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/1019156?dopt=AbstractPlus

49. Honorato J, Masso RM, Purroy A. The use of gemfibrozil in the treatment of primary hyperlipoproteinaemia. Preliminary report. Proc R Soc Med. 1976; 69(Suppl 2):78-9. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864036&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/798200?dopt=AbstractPlus

50. de la Iglesia FA, Pinn SM, Lucas J et al. Quantitative stereology of peroxisomes in hepatocytes from hyperlipoproteinemic patients receiving gemfibrozil. Micron. 1981; 12:97-8.

51. Bremner WF, Third JLHC, Clark B et al. CI-719 in hyperlipoproteinaemia: interim data. Proc R Soc Med. 1976; 69(Suppl 2):83-7. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864018&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/798201?dopt=AbstractPlus

52. Howard AN, Ghosh P. Gemfibrozil treatment: a comparison with clofibrate. Proc R Soc Med. 1976; 69(Suppl 2):88-9. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864044&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/190609?dopt=AbstractPlus

53. Wilkening J, Schwandt P. Summary of present data from a clinical trial of CI-719. Proc R Soc Med. 1976; 69(Suppl 2):90-3. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864022&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/1019158?dopt=AbstractPlus

54. Kissebah AH, Adams PA, Wynn V. Lipokinetic studies with gemfibrozil (CI-719). Proc R Soc Med. 1976; 69(Suppl 2):94-7. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864040&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/190610?dopt=AbstractPlus

55. Elkeles RS, Ashwell M, Priest R et al. The effect of CI-719 on lipolysis in rat adipose tissue. Proc R Soc Med. 1976; 69(Suppl 2):98-100. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864028&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/1019159?dopt=AbstractPlus

56. C.dtdon LA. Effect of gemfibrozil in vitro on fat-mobilizing lipolysis in human adipose tissue. Proc R Soc Med. 1976; 69(Suppl 2):101-3.

57. Kallai-Sanfacon MA, Cayen MN, Dubuc J et al. Effect of AY-25, 712 and other lipid-lowering agents on liver catalase and liver carnitine acetyltransferase in rats (41658). Proc Soc Exp Biol Med. 1983; 173:367-71. http://www.ncbi.nlm.nih.gov/pubmed/6867010?dopt=AbstractPlus

58. O’Brien JR, Etherington MD, Shuttleworth RD et al. A pilot study of the effect of gemfibrozil on some haematological parameters. Thrombosis Res. 1982; 26:275-9.

59. Rasi VPO, Torstila I. Effect of gemfibrozil upon platelet function and blood coagulation. preliminary report. Proc R Soc Med. 1976; 69(Suppl 2):109-11. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1864038&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/1019149?dopt=AbstractPlus

60. Wynn V, chairman. Gemfibrozil: a new lipid lowering agent: open forum. Proc R Soc Med. 1976; 69(Suppl 2):115-20.

61. Leiss O, von Bergmann K, Gnasso A et al. Effect of gemfibrozil on biliary lipid metabolism in normolipemic subjects. Metabolism. 1985; 34:74-82. http://www.ncbi.nlm.nih.gov/pubmed/3855325?dopt=AbstractPlus

62. Fitzgerald JE, Sanyer JL, Schardein JL et al. Carcinogen bioassay and mutagenicity studies with the hypolipidemic agent gemfibrozil. J Natl Cancer Inst. 1981; 67:1105-14. http://www.ncbi.nlm.nih.gov/pubmed/7029098?dopt=AbstractPlus

63. Nash DT. Gemfibrozil—a new lipid lowering agent. J Med. 1980; 11:107-16. http://www.ncbi.nlm.nih.gov/pubmed/6931871?dopt=AbstractPlus

64. National Institutes of Health Office of Medical Applications of Research. Consensus conference: treatment of hypertriglyceridemia. JAMA. 1984; 251:1196-1200. http://www.ncbi.nlm.nih.gov/pubmed/6582287?dopt=AbstractPlus

65. Levy RI. Current status of the cholesterol controversy. Am J Med. 1983; 74(Suppl 5A):1-4. http://www.ncbi.nlm.nih.gov/pubmed/6342382?dopt=AbstractPlus

66. Kuo PT. Hyperlipoproteinemia and atherosclerosis: dietary intervention. Am J Med. 1983; 74(Suppl 5A):15-8. http://www.ncbi.nlm.nih.gov/pubmed/6846377?dopt=AbstractPlus

67. Hunninghake DB. Pharmacologic therapy for the hyperlipidemic patient. Am J Med. 1983; 74(Suppl 5A):19-22. http://www.ncbi.nlm.nih.gov/pubmed/6846378?dopt=AbstractPlus

68. Anon. Gemfibrozil for hyperlipidemia. Med Lett Drugs Ther. 1982; 24:59-60. http://www.ncbi.nlm.nih.gov/pubmed/6953310?dopt=AbstractPlus

69. Probstfield JL, Gotto AM Jr. Disorders of lipids and lipoproteins. In: Stein JH, ed. Internal medicine. Boston: Little Brown and Company; 1983:1888-93.

70. National Institutes of Health Office of Medical Applications of Research. Consensus Conference: lowering blood cholesterol to prevent heart disease. JAMA. 1985; 253:2080-6. http://www.ncbi.nlm.nih.gov/pubmed/3974099?dopt=AbstractPlus

71. Gordon T, Castelli WP, Hjortland MC et al. High density lipoprotein as a protective factor against coronary heart disease: the Framingham study. Am J Med. 1977; 62:707-14. http://www.ncbi.nlm.nih.gov/pubmed/193398?dopt=AbstractPlus

72. Glueck CJ. Relationship of lipid disorders to coronary heart disease. Am J Med. 1983; 74(Suppl 5A):10-4. http://www.ncbi.nlm.nih.gov/pubmed/6846376?dopt=AbstractPlus

73. American Heart Association Committee to Design a Dietary Treatment of Hyperlipoproteinemia. Recommendations for treatment of hyperlipidemia in adults: a joint statement of the Nutrition Committee and the Council on Arteriosclerosis. Circulation. 1984; 69:1065-90A. http://www.ncbi.nlm.nih.gov/pubmed/6713610?dopt=AbstractPlus

74. Weinberger MH. Antihypertensive therapy and lipids: evidence, mechanisms, and implications. Arch Intern Med. 1985; 145:1102-5. http://www.ncbi.nlm.nih.gov/pubmed/2860883?dopt=AbstractPlus

75. Kissebah AH, Alfarsi S, Adams PW et al. Transport kinetics of plasma free fatty acids, very low density lipoprotein triglycerides and apoprotein in patients with endogenous hypertriglyceridemia: effects of 2,2-dimethyl,5(2,5-xylyloxy)valic acid therapy. Atherosclerosis. 1976; 24:199-218. http://www.ncbi.nlm.nih.gov/pubmed/182185?dopt=AbstractPlus

76. Brown MS, Goldstein JL. Drugs used in the treatment of hyperlipoproteinemias. In: Gilman AG, Goodman LS, Rall TW et al, eds. Goodman and Gilman’s the pharmacological basis of therapeutics. 7th ed. New York: The Macmillan Company; 1985:827-45.

77. National Heart, Lung, and Blood Institute Lipid Metabolism—Atherogenesis Branch. The lipid research clinics coronary primary prevention trial results: part I. Reduction in incidence of coronary heart disease. JAMA. 1984; 251:351-64. http://www.ncbi.nlm.nih.gov/pubmed/6361299?dopt=AbstractPlus

78. National Heart, Lung, and Blood Institute Lipid Metabolism—Atherogenesis Branch. The lipid research clinics coronary primary prevention trial results: part II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA. 1984; 251:365-74. http://www.ncbi.nlm.nih.gov/pubmed/6361300?dopt=AbstractPlus

79. Hansten PD. Drug interactions. 5th ed. Philadelphia: Lea & Febiger; 1985:76.

80. Manninen V, Malkonen M. Effect of gemfibrozil on the blood levels of the high density lipoprotein subfractions HDL2 and HDL3. Res Clin Forums. 1982; 4:77-83.

81. W.H.O. cooperative trial on primary prevention of ischaemic heart disease using clofibrate to lower serum cholesterol: mortality follow-up. Report from the Committee of Principal Investigators. Lancet. 1980; 2:379-85.

82. A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Report from the Committee of Principal Investigators. Br Heart J. 1978; 40:1069-118. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=483536&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/361054?dopt=AbstractPlus

83. WHO cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: final mortality follow-up. Report from the Committee of Principal Investigators. Lancet. 1984; 2:600-4. http://www.ncbi.nlm.nih.gov/pubmed/6147641?dopt=AbstractPlus

84. The Coronary Drug Project Research Group. Clofibrate and niacin in coronary heart disease. JAMA. 1975; 231:360-81. http://www.ncbi.nlm.nih.gov/pubmed/1088963?dopt=AbstractPlus

85. The Coronary Drug Project Research Group. Gallbladder disease as a side effect of drugs influencing lipid metabolism: experience in the Coronary Drug Project. N Engl J Med. 1977; 296:1185-90. http://www.ncbi.nlm.nih.gov/pubmed/323705?dopt=AbstractPlus

86. Oliver MF. Cholesterol, coronaries, clofibrate and death. N Engl J Med. 1978; 299:1360-2. http://www.ncbi.nlm.nih.gov/pubmed/362204?dopt=AbstractPlus

87. Green KG. Interpretation of clofibrate trial. Lancet. 1984; 2:1095-6. http://www.ncbi.nlm.nih.gov/pubmed/6150164?dopt=AbstractPlus

88. Glueck CJ. Nonpharmacologic and pharmacologic alteration of high-density lipoprotein cholesterol: therapeutic approaches to prevention of atherosclerosis. Am Heart J. 1985; 110:1107-15. http://www.ncbi.nlm.nih.gov/pubmed/2865887?dopt=AbstractPlus

89. American Medical Association Council on Scientific Affairs. Dietary and pharmacologic therapy for the lipid risk factors. JAMA. 1983; 250:1873-9. http://www.ncbi.nlm.nih.gov/pubmed/6620484?dopt=AbstractPlus

90. Anon. Lipid-lowering drugs. Med Lett Drugs Ther. 1985; 27:74-6. http://www.ncbi.nlm.nih.gov/pubmed/3860714?dopt=AbstractPlus

91. Saku K, Gartside PS, Hynd BA et al. Mechanism of action of gemfibrozil on lipoprotein metabolism. J Clin Invest. 1985; 75:1702-12. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=425514&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/3923042?dopt=AbstractPlus

92. Grundy SM. Consensus statement: role of therapy with “statins” in patients with hypertriglyceridemia. Am J Cardiol. 1998; 81:1-6B. http://www.ncbi.nlm.nih.gov/pubmed/9462596?dopt=AbstractPlus

93. Mahley RW. Atherogenic lipoproteins and coronary artery disease: concepts derived from recent advances in cellular and molecular biology. Circulation. 1985; 72:943-8. http://www.ncbi.nlm.nih.gov/pubmed/4042302?dopt=AbstractPlus

94. Reviewers’ comments (personal observations); 1985 Dec.

95. Cheung MC, Albers JJ, Wahl PW et al. High density lipoproteins during hypolipidemic therapy: a comparative study of four drugs. Atherosclerosis. 1980; 35:215-28. http://www.ncbi.nlm.nih.gov/pubmed/7362696?dopt=AbstractPlus

96. Hazzard WR, Wahl PW, Gagne C et al. Plasma and lipoprotein lipid responses to four hypolipid drugs. Lipids. 1984; 19:73-9. http://www.ncbi.nlm.nih.gov/pubmed/6708754?dopt=AbstractPlus

97. Pierides AM, Alvarez-Ude F, Kerr DN. Clofibrate-induced muscle damage in patients with chronic renal failure. Lancet. 1975; 2:1279-82. http://www.ncbi.nlm.nih.gov/pubmed/54800?dopt=AbstractPlus

98. Bridgman JF, Rosen SM, Thorp JM. Complications during clofibrate treatment on nephrotic-syndrome hyperlipoproteinaemia. Lancet. 1972; 2:506-9. http://www.ncbi.nlm.nih.gov/pubmed/4115569?dopt=AbstractPlus

99. Levy RI, Brensike JF, Epstein SE et al. The influence of changes in lipid values induced by cholestyramine and diet on progression of coronary artery disease: results of the NHLBI Type II Coronary Intervention Study. Circulation. 1984; 69:325-37. http://www.ncbi.nlm.nih.gov/pubmed/6360415?dopt=AbstractPlus

100. Gosselin RE, Smith RP, Hodge HC. Clinical toxicology of commercial products. 5th ed. Baltimore: Williams & Wilkins; 1984:I-10.

101. Brensike JF, Levy RI, Kelsey SF et al. Effects of therapy with cholestyramine on progression of coronary arteriosclerosis: results of the NHLBI Type II Coronary Intervention Study. Circulation. 1984; 69:313-24. http://www.ncbi.nlm.nih.gov/pubmed/6360414?dopt=AbstractPlus

102. Rhodes DF (Parke-Davis, Morris Plains, NJ): Personal communication; 1986 Jan 21.

103. Hoeg JM, Gregg RE, Brewer HB. An approach to the management of hyperlipoproteinemia. JAMA. 1986; 255:512-21. http://www.ncbi.nlm.nih.gov/pubmed/3510334?dopt=AbstractPlus

104. Frick MH, Elo O, Haapa K et al. Helsinki Heart Study: primary prevention trial with gemfibrozil in middle-aged men with dyslipidemia: safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med. 1987; 317:1237-45. http://www.ncbi.nlm.nih.gov/pubmed/3313041?dopt=AbstractPlus

105. Rifkind BM. Gemfibrozil, lipids, and coronary risk. N Engl J Med. 1987; 317:1279-81. http://www.ncbi.nlm.nih.gov/pubmed/3313042?dopt=AbstractPlus

106. The Expert Panel (coordinated by the National Heart, Lung, and Blood Institute). Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Arch Intern Med. 1988; 148:36-69. http://www.ncbi.nlm.nih.gov/pubmed/3422148?dopt=AbstractPlus

107. Gordon DJ, Knoke J, Probstfield JL et al. High-density lipoprotein cholesterol and coronary heart disease in hypercholesterolemic men: the Lipid Research Clinics Coronary Primary Prevention Trial. Circulation. 1986; 74:1217-25. http://www.ncbi.nlm.nih.gov/pubmed/3536151?dopt=AbstractPlus

108. Tobert JA. Rhabdomyolysis in patients receiving lovastatin after cardiac transplantation. N Engl J Med. 1988; 318:48. http://www.ncbi.nlm.nih.gov/pubmed/3257291?dopt=AbstractPlus

109. Fisher DA, Elias PM, LeBoit PL. Exacerbation of psoriasis by the hypolipidemic agent, gemfibrozil. Arch Dermatol. 1988; 124:854-5. http://www.ncbi.nlm.nih.gov/pubmed/3163912?dopt=AbstractPlus

110. Manninen V, Elo O, Frick MH et al. Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study. JAMA. 1988; 260:641-51. http://www.ncbi.nlm.nih.gov/pubmed/3164788?dopt=AbstractPlus

111. Manninen V, Frick MH, Heinonen OP et al. Lipid level alterations in the Helsinki Heart Study. JAMA. 1989; 261:554-5. http://www.ncbi.nlm.nih.gov/pubmed/2909790?dopt=AbstractPlus

112. American Heart Association. AHA conference report on cholesterol. Circulation. 1989; 80:715-48. http://www.ncbi.nlm.nih.gov/pubmed/2670320?dopt=AbstractPlus

113. Miller NE. Associations of high-density lipoprotein subclasses and apolipoproteins with ischemic heart disease and coronary atherosclerosis. Am Heart J. 1987; 113:589-97. http://www.ncbi.nlm.nih.gov/pubmed/3544775?dopt=AbstractPlus

114. Pocock SJ, Shaper AG, Phillips AN et al. High density lipoprotein cholesterol is not a major risk factor for ischaemic heart disease in British men. BMJ. 1986; 292:515-9. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1339503&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/3081149?dopt=AbstractPlus

115. Langer T, Levy RI. Acute muscular syndrome associated with administration of clofibrate. N Engl J Med. 1968; 279:856-8. http://www.ncbi.nlm.nih.gov/pubmed/5677720?dopt=AbstractPlus

116. East C, Alivizatos PA, Grundy SM et al. Rhabdomyolysis in patients receiving lovastatin after cardiac transplantation. N Engl J Med. 1988; 318:47-8. http://www.ncbi.nlm.nih.gov/pubmed/3275892?dopt=AbstractPlus

117. Sekowski I, Samuel P. Clofibrate-induced acute muscular syndrome. Am J Cardiol. 1972; 30:572-4. http://www.ncbi.nlm.nih.gov/pubmed/5073673?dopt=AbstractPlus

118. Goldstein MR. Myopathy and rhabdomyolysis with lovastatin taken with gemfibrozil. JAMA. 1990; 264:2991. http://www.ncbi.nlm.nih.gov/pubmed/2243420?dopt=AbstractPlus

119. Van Lente F, Cornell W. Myopathy and rhabdomyolysis with lovastatin taken with gemfibrozil. JAMA. 1990; 264:2991-2. http://www.ncbi.nlm.nih.gov/pubmed/2243420?dopt=AbstractPlus

120. Pierce LR, Wysowski DK, Gross TP. Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy. JAMA. 1990; 264:71-5. http://www.ncbi.nlm.nih.gov/pubmed/2355431?dopt=AbstractPlus

121. Marais GE, Larson KK. Rhabdomyolysis and acute renal failure induced by combination lovastatin and gemfibrozil therapy. Ann Intern Med. 1990; 112:228-30. http://www.ncbi.nlm.nih.gov/pubmed/2297197?dopt=AbstractPlus

122. Mäntari M, Romo M, Manninen V et al. Reduction in Q wave myocardial infarctions with gemfibrozil in the Helsinki heart study. Am Heart J. 1990; 119:991-5. http://www.ncbi.nlm.nih.gov/pubmed/2330888?dopt=AbstractPlus

123. Pizarro S, Bargay J, D’Agosto P. Gemfibrozil-induced impotence. Lancet. 1990; 336:1135.

124. Ahmad S. Gemfibrozil interaction with warfarin sodium (Coumadin). Chest. 1990; 98:1041-2. http://www.ncbi.nlm.nih.gov/pubmed/2209118?dopt=AbstractPlus

125. Bain SC, Lemon M, Jones AF. Gemfibrozil-induced impotence. Lancet. 1990; 336:1389. http://www.ncbi.nlm.nih.gov/pubmed/1978207?dopt=AbstractPlus

126. Lopid (gemfibrozil tablets) prescribing information. In: Physician’s desk reference. 47th ed. Montvale, NJ: Medical Economics Company Inc; 1993 (Suppl A):A144.

127. The Expert Panel. Second Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). Circulation. 1994; 89:1329-1445.

128. Lopid (gemfibrozil) prescibing information. In: Pysicians’ desk reference. 52nd ed. Montvale, NJ: Medical Economics Company Inc; 1998(Suppl A):A242.

129. Gibbons RJ, Chatterjee K, Daley J et al. ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology, American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients with Chronic Stable Angina). J Am Coll Cardiol. 1999; 33:2092-197. http://www.ncbi.nlm.nih.gov/pubmed/10362225?dopt=AbstractPlus

130. Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Survival Study (4S). Lancet. 1994; 344:1383-9. http://www.ncbi.nlm.nih.gov/pubmed/7968073?dopt=AbstractPlus

131. Sacks FN, Pfeffer MA, Maye LA et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med. 1996; 335:1001-9. http://www.ncbi.nlm.nih.gov/pubmed/8801446?dopt=AbstractPlus

132. The Long-term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med. 1998; 339:1349-57. http://www.ncbi.nlm.nih.gov/pubmed/9841303?dopt=AbstractPlus

133. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of high Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001; 285:2486-97. http://www.ncbi.nlm.nih.gov/pubmed/11368702?dopt=AbstractPlus

134. Anon. Bayer voluntarily withdraws Baycol. FDA Talk Paper. Rockville, MD: Food and Drug Administration; 2001 Aug 8.

135. Mac Carthy EP. Dear Doctor letter regarding market withdrawal of Baycol (cerivastatin). West Haven, CT: Bayer Corporation; 2001 Aug 8.

136. National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Adult Treatment Panel III Report. From AHA web site. http://www.nhlbi.nih.gov/guidelines/cholesterol/atp3_rpt.htm

137. Rubins HB, Robins SJ, Collins D et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. New Engl J Med. 1999; 341:410-8. http://www.ncbi.nlm.nih.gov/pubmed/10438259?dopt=AbstractPlus

138. Novo Nordisk Pharmaceuticals, Inc. Prandin (repaglinide) tablets prescribing information. Princeton, NJ; 2003 Aug.

139. Niemi M, Backman JT, Neuvonen M et al. Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide. Diabetologia. 2003; 46:347-51. http://www.ncbi.nlm.nih.gov/pubmed/12687332?dopt=AbstractPlus

352. Eckel RH, Jakicic JM, Ard JD et al. 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014; 63:2960-84. http://www.ncbi.nlm.nih.gov/pubmed/24239922?dopt=AbstractPlus

353. ACCORD Study Group, Ginsberg HN, Elam MB et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med. 2010; 362:1563-74. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=2879499&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/20228404?dopt=AbstractPlus

356. Miller M, Stone NJ, Ballantyne C et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2011; 123:2292-333. http://www.ncbi.nlm.nih.gov/pubmed/21502576?dopt=AbstractPlus

400. Grundy SM, Stone NJ, Bailey AL et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019; 139:e1082-e1143. http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=PMC7403606&blobtype=pdf http://www.ncbi.nlm.nih.gov/pubmed/30586774?dopt=AbstractPlus

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