Amoxicillin (Monograph)
Brand names: Amoxil, Larotid
Drug class: Aminopenicillins
Introduction
Antibacterial; β-lactam antibiotic; aminopenicillin.6 62
Uses for Amoxicillin
Otitis Media
Treatment of acute otitis media (AOM).1 140 176 177 190 192 199 200 209 210 211 683 AAP, AAFP, CDC, and others consider amoxicillin the drug of first choice for initial treatment of AOM, unless the infection is suspected of being caused by β-lactamase-producing bacteria resistant to the drug, in which case the fixed combination of amoxicillin and clavulanate is recommended for initial treatment.190 200 202 204 205 210 683 Those who fail to respond to amoxicillin should be retreated with amoxicillin and clavulanate.683
Has been used for management of otitis media with effusion† [off-label] (OME).193 206 208 219 221 227 Anti-infectives not usually recommended;111 115 206 208 219 221 245 they provide only limited benefit in enhancing resolution of effusion and may promote resistance.115 207 208 219 AAP, AAFP, and others recommend watchful waiting for 3 months from date of effusion onset or diagnosis in those 2 months to 12 years of age who are not at risk for speech, language, or learning problems; some suggest a short course of anti-infectives may be considered for possible short-term benefits when parent and/or caregiver expresses a strong aversion to impending surgery.245 If anti-infectives are used, amoxicillin or the fixed combination of amoxicillin and clavulanate recommended.219 221 227
Pharyngitis and Tonsillitis
Treatment of pharyngitis and tonsillitis caused by Streptococcus pyogenes (group A β-hemolytic streptococci; GAS) and prevention of initial attacks (primary prevention) of rheumatic fever.1 6 35 39 108 109 110 292 375 580
AAP, IDSA, and AHA recommend a penicillin regimen (i.e., 10 days of oral penicillin V or oral amoxicillin or single dose of IM penicillin G benzathine) as treatment of choice for S. pyogenes pharyngitis and tonsillitis;292 375 580 other anti-infectives (narrow-spectrum oral cephalosporins, oral macrolides, oral clindamycin) recommended as alternatives in penicillin-allergic patients.292 375 580
If signs and symptoms of pharyngitis recur shortly after initial treatment and presence of S. pyogenes documented, retreatment with original or alternative anti-infective recommended.292 375 580 Alternative regimens recommended for retreatment include a narrow-spectrum oral cephalosporin, oral clindamycin, oral fixed combination of amoxicillin and clavulanate, oral macrolide, or IM penicillin G benzathine.292 375 580
Consider that multiple, recurrent episodes of symptomatic pharyngitis within a period of several months to years may indicate that patient is a long-term pharyngeal carrier of S. pyogenes experiencing repeated episodes of nonstreptococcal (e.g., viral) pharyngitis.292 375 580
Treatment not usually recommended for asymptomatic chronic pharyngeal carriers of S. pyogenes.292 375 580 Eradication of the carrier state may be desirable in certain situations (e.g., community outbreak of acute rheumatic fever, acute poststreptococcal glomerulonephritis, or invasive S. pyogenes infections; outbreak of S. pyogenes pharyngitis in a closed or partially closed community; multiple episodes of documented symptomatic S. pyogenes pharyngitis occurring within a family for many weeks despite appropriate treatment; personal or family history of acute rheumatic fever).292 580 In such situations, recommended regimens include oral clindamycin, oral fixed combination of amoxicillin and clavulanate, or either IM penicillin G benzathine or oral penicillin V used in conjunction with oral rifampin.292 580
Respiratory Tract Infections
Treatment of lower respiratory tract infections caused by susceptible Streptococcus (α- or β-hemolytic strains only), S. pneumoniae, Staphylococcus, or H. influenzae.1 6 57 62 73 81
Skin and Skin Structure Infections
Treatment of skin and skin structure infections caused by susceptible Streptococcus (α- or β-hemolytic strains only), Staphylococcus, or Escherichia coli.1
Urinary Tract Infections (UTIs)
Treatment of UTIs caused by susceptible Enterococcus faecalis, Escherichia coli, or Proteus mirabilis.1 3 4 6 75 76 78 81 A drug of choice for treatment of uncomplicated UTIs caused by E. faecalis;81 consider high incidence of amoxicillin-resistant E. coli and other Enterobacteriaceae.6
Gonorrhea
Previously used for treatment of acute uncomplicated gonorrhea (anogenital and urethral) caused by susceptible Neisseria gonorrhoeae.1 6 184 However, CDC has not recommended use of penicillins for treatment of gonorrhea for over 30 years because of the widespread prevalence of penicillinase-producing strains of N. gonorrhoeae (PPNG).344
Typhoid Fever and other Salmonella Infections
Alternative for treatment of typhoid fever† [off-label] (enteric fever) caused by susceptible Salmonella typhi.6 57 64 66 68 81 190 Drugs of choice are fluoroquinolones and third generation cephalosporins (e.g., ceftriaxone, cefotaxime);81 190 consider that multidrug-resistant strains of S. typhi (strains resistant to ampicillin, amoxicillin, chloramphenicol, and/or co-trimoxazole) reported with increasing frequency.102 190
Treatment of chronic carriers of S. typhi† [off-label]; drugs of choice are fluoroquinolones (e.g., ciprofloxacin), ampicillin, or amoxicillin (with probenecid).6 62 63 65 67 81
Alternative for treatment of gastroenteritis caused by nontyphoidal Salmonella† [off-label].190 Anti-infectives not indicated in otherwise healthy individuals with uncomplicated (noninvasive) gastroenteritis, but recommended if gastroenteritis is severe and in those at increased risk of invasive disease (e.g., <6 months or >50 years of age; hemoglobinopathies, severe atherosclerosis, valvular heart disease, prostheses, uremia, chronic GI disease, severe colitis; immunocompromised because of malignancy, immunosuppressive therapy, HIV infection).81 120 121 190 Drugs of choice are fluoroquinolones, third generation cephalosporins (cefotaxime, ceftriaxone), ampicillin, amoxicillin, co-trimoxazole, or chloramphenicol, depending on in vitro susceptibility.81 120 121 190
Helicobacter pylori Infection and Duodenal Ulcer Disease
Treatment of Helicobacter pylori infection and duodenal ulcer disease (active or 1-year history of duodenal ulcer);1 168 172 173 174 eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence.1 107 116 119 122 168 172 173
Used in a multidrug regimen that includes amoxicillin, clarithromycin, and either lansoprazole or omeprazole (triple therapy).1 81 107 168 169 172 173 174 175 Used with lansoprazole (dual therapy) in those allergic to or intolerant of clarithromycin or when clarithromycin resistance is suspected.1 168 169
Lyme Disease
Treatment of erythema migrans and certain other manifestations of Lyme disease† [off-label].292 329 331
IDSA, AAP, American Academy of Neurology (AAN), American College of Rheumatology (ACR), and others consider amoxicillin a drug of choice for treatment of erythema migrans†.292 329 331 Also considered a drug of choice when an oral regimen is indicated for the treatment of Lyme carditis† or Lyme arthritis†.329 331 179 181 182 185 186 232 238
Chlamydial Infections
Treatment of uncomplicated urethritis and cervicitis caused by Chlamydia trachomatis in pregnant women†.81 157 190 344 CDC recommends azithromycin as drug of choice and amoxicillin as alternative for treatment of urogenital chlamydial infections in pregnant women.344
Prevention of Bacterial Endocarditis
Prevention of α-hemolytic (viridans group) bacterial endocarditis† in patients undergoing certain dental procedures (i.e., procedures that involve manipulation of gingival tissue or periapical region of teeth or perforation of oral mucosa) or certain invasive respiratory tract procedures (i.e., procedures involving incision or biopsy of respiratory mucosa) who have certain cardiac conditions that put them at highest risk of adverse outcomes from endocarditis.69 72 97 99 100 101 451 AHA recommends amoxicillin as drug of choice for such prophylaxis.451
Anti-infective prophylaxis solely for prevention of bacterial endocarditis no longer recommended by AHA for patients undergoing GU or GI procedures.451
Consult most recent AHA recommendations for information on which cardiac conditions are associated with highest risk of adverse outcomes from endocarditis and specific recommendations regarding use of prophylaxis to prevent endocarditis in these patients.451
Prevention of S. pneumoniae Infections in Asplenic Individuals
Prevention of invasive S. pneumoniae infections in children with anatomic or functional asplenia† (e.g., congenital, resulting from sickle cell disease or surgery)190 or children with malignant neoplasms or thalassemia.190
Oral penicillin V usually drug of choice;74 190 some experts recommend amoxicillin.190
Children at increased risk for pneumococcal infections should receive age-appropriate vaccination with pneumococcal 13-valent conjugate vaccine (PCV13) and pneumococcal 23-valent polysaccharide vaccine (PPSV23).190 243 Long-term anti-infective prophylaxis recommended for children with functional or anatomic asplenia regardless of vaccination status.74 190 243
Anthrax
Alternative for postexposure prophylaxis of anthrax† following exposure to Bacillus anthracis spores (inhalational anthrax).190 228 229 231 233 235 236 239 671 672 673 Ciprofloxacin or doxycycline are initial drugs of choice for prophylaxis following suspected or confirmed exposure to aerosolized anthrax spores, including exposures that occur in the context of biologic warfare or bioterrorism.190 231 235 671 672 673 If penicillin susceptibility confirmed, consideration can be given to changing prophylaxis to a penicillin (oral amoxicillin or penicillin V) in infants and children, pregnant or lactating women, or when drugs of choice not tolerated or not available;671 672 673 amoxicillin may be preferred, especially in infants and children.671
Alternative for treatment of inhalational anthrax† when a parenteral regimen not available (e.g., when there are supply or logistic problems in a mass-casualty setting).231
Alternative for treatment of cutaneous anthrax† caused by susceptible B. anthracis.231 671 672 673 If cutaneous anthrax occurs in the context of biologic warfare or bioterrorism, initial drugs of choice are ciprofloxacin or doxycycline.231 671 672 673 If penicillin susceptibility confirmed, consideration can be given to changing to a penicillin (oral amoxicillin or penicillin V) in infants and children, pregnant or lactating women, or when drugs of choice not tolerated or not available;671 672 673 amoxicillin may be preferred, especially in infants and children.671
Amoxicillin Dosage and Administration
Administration
Oral Administration
Administer orally without regard to meals.1 4 10 22 29 38 40
Following reconstitution, the required amount of oral suspension should be placed directly on the child’s tongue for swallowing.1 Alternatively, the required amount of suspension can be added to infant formula, milk, fruit juice, water, ginger ale, or cold drinks and these fluids taken immediately and completely consumed.1
For most infections, continue therapy for at least 48–72 hours after patient becomes asymptomatic or evidence that the infection is eradicated is obtained.1 The drug should be given for at least 10 days for treatment of infections caused by S. pyogenes (group A β-hemolytic streptococci).1
Reconstitution
Reconstitute oral suspension at the time of dispensing.1 Tap bottle to thoroughly loosen powder and then add the amount of water specified on the bottle in 2 portions; agitate vigorously after each addition.1
Agitate suspension well prior to administration of each dose.1
Dosage
Available as the trihydrate;1 dosage expressed in terms of anhydrous amoxicillin.1
Pediatric Patients
General Pediatric Dosage
Oral
Neonates and infants ≤12 weeks (3 months) of age: Manufacturer states dosage up to 30 mg/kg daily can be given in divided doses every 12 hours.1
Children ≥3 months of age weighing ≥40 kg: Manufacturer states use usual adult dosage.1
Children beyond neonatal period with mild to moderate infections: AAP recommends 25–50 mg/kg daily given in 3 divided doses.292
Children beyond neonatal period with severe infections: AAP states that 80–100 mg/kg daily given in 3 divided doses can be used for step-down therapy.292 For highly susceptible pathogens, 90 mg/kg daily given in 2 divided doses can be used.292
Otitis Media
Treatment of Acute Otitis Media (AOM)
Oral80–90 mg/kg daily given in 2 or 3 divided doses† recommended by AAP, AAFP, CDC, and others.190 200 201 205 215 683
Usual duration is 10 days;190 200 201 205 215 optimal duration uncertain.683 AAP recommends 10 days of treatment in those <2 years of age and in those with severe symptoms.683 For mild to moderate AOM in older children, AAP states 7- and 10-day regimens appear equally effective in those 2–5 years of age and a duration of 5–7 days may be adequate in those ≥6 years of age.683
Pharyngitis and Tonsillitis
Oral
45 mg/kg daily in 2 divided doses or 40 mg/kg daily in 3 divided doses for 10 days recommended by manufacturer.1
AHA and AAP recommend 50 mg/kg (up to 1 g) once daily for 10 days.292 375
IDSA recommends 50 mg/kg (up to 1 g) once daily for 10 days or 25 mg/kg (up to 500 mg) twice daily for 10 days.580
Ear, Nose, and Throat Infections
Oral
25 mg/kg daily in divided doses every 12 hours or 20 mg/kg daily in divided doses every 8 hours for mild to moderate infections.1
45 mg/kg daily in divided doses every 12 hours or 40 mg/kg in divided doses every 8 hours for severe infections.1
Respiratory Tract Infections
Oral
45 mg/kg daily in divided doses every 12 hours or 40 mg/kg daily in divided doses every 8 hours for mild, moderate, or severe lower respiratory tract infections.1
Skin and Skin Structure Infections
Oral
25 mg/kg daily in divided doses every 12 hours or 20 mg/kg daily in divided doses every 8 hours for mild to moderate infections.1
45 mg/kg daily in divided doses every 12 hours or 40 mg/kg daily in divided doses every 8 hours for severe infections or those caused by less susceptible bacteria.1
Urinary Tract Infections (UTIs)
Oral
25 mg/kg daily in divided doses every 12 hours or 20 mg/kg daily in divided doses every 8 hours for mild to moderate infections.1
45 mg/kg daily in divided doses every 12 hours or 40 mg/kg daily in divided doses every 8 hours for severe infections or those caused by less susceptible bacteria.1
Gonorrhea
Oral
Prepubertal children ≥2 years of age: Manufacturer recommends 50 mg/kg as a single dose given with a single dose of probenecid (25 mg/kg) recommended by manufacturer.1
No longer recommended for gonorrhea by CDC.344
Lyme Disease†
Erythema Migrans†
Oral50 mg/kg daily in 3 divided doses (maximum 500 mg per dose) for 14 days.292 329 331
Lyme Carditis†
Oral50 mg/kg daily in 3 divided doses (maximum 500 mg per dose) for 14–21 days.329 331 Use in outpatients when an IV regimen not required or as follow-up after an initial IV regimen.329 331
Lyme Arthritis†
Oral50 mg/kg daily in 3 divided doses (maximum 500 mg per dose) for 28 days.329 331
Prevention of Bacterial Endocarditis†
Patients Undergoing Certain Dental or Respiratory Tract Procedures†
Oral50 mg/kg given as a single dose 30–60 minutes prior to the procedure.451
Prevention of S. pneumoniae Infections in Asplenic Individuals†
Oral
20 mg/kg daily in children with anatomic or functional asplenia.190
In infants with sickle cell anemia, initiate prophylaxis as soon as diagnosis is established (preferably by 2 months of age);74 190 continue until approximately 5 years of age.74 190 243 Appropriate duration in children with asplenia from other causes unknown;190 some experts recommend that asplenic children at high risk receive prophylaxis throughout childhood and into adulthood.190
Anthrax†
Postexposure Prophylaxis of Anthrax†
OralFull-term neonates ≤4 weeks of age: AAP recommends 75 mg/kg daily given in divided doses every 8 hours.671
Preterm neonates (gestational age 32–37 weeks): AAP recommends 50 mg/kg daily given in divided doses every 12 hours in those ≤1 week of age and 75 mg/kg daily given in divided doses every 8 hours in those 1–4 weeks of age.671
Infants and children ≥1 month of age: AAP recommends 75 mg/kg daily (up to 1 g daily) given in divided doses every 8 hours.671
Children: Some experts recommend 80 mg/kg daily given in divided doses every 8 hours in those weighing <20 kg and 500 mg every 8 hours in those weighing ≥20 kg.231
Use only if penicillin-susceptible B. anthracis involved.671
Total duration of anti-infective prophylaxis should be ≥60 days.190 231 233 239 671
Treatment of Inhalational Anthrax†
OralFull-term neonates ≤4 weeks of age for follow-up after initial parenteral regimen: AAP recommends 75 mg/kg daily given in divided doses every 8 hours in conjunction with other anti-infectives.671
Preterm neonates (gestational age 32–37 weeks) for follow-up after initial parenteral regimen: AAP recommends 50 mg/kg daily given in divided doses every 12 hours in those ≤1 week of age and 75 mg/kg daily given in divided doses every 8 hours in those 1–4 weeks of age in conjunction with other anti-infectives.671
Infants and children ≥1 month of age for follow-up after initial parenteral regimen: 75 mg/kg daily (up to 1 g daily) given in divided doses every 8 hours in conjunction with other anti-infectives.671
Children with inhalational anthrax in mass casualty setting when parenteral anti-infectives not available: Some experts recommend 80 mg/kg daily given in divided doses every 8 hours in those weighing <20 kg and 500 mg every 8 hours in those weighing ≥20 kg.231
Recommended dosages are for infections that occur in the context of biologic warfare or bioterrorism231 671 and when meningitis can be ruled out.671
Use only if infection known to be caused by penicillin-susceptible B. anthracis.671
Total duration of anti-infective treatment should be 60 days.231 671
Treatment of Cutaneous Anthrax†
OralFull-term neonates ≤4 weeks of age with cutaneous anthrax without systemic involvement: AAP recommends 75 mg/kg daily given in divided doses every 8 hours.671
Preterm neonates (gestational age 32–37 weeks) with cutaneous anthrax without systemic involvement: AAP recommends 50 mg/kg daily given in divided doses every 12 hours in those ≤1 week of age and 75 mg/kg daily given in divided doses every 8 hours in those 1–4 weeks of age.671
Infants and children ≥1 month of age with cutaneous anthrax without systemic involvement: AAP recommends 75 mg/kg daily (up to 1 g daily) given in divided doses every 8 hours.671
Children: Some experts recommend 80 mg/kg daily (up to 1.5 g daily) given in divided doses every 8 hours.231
Recommended dosages are for infections that occur in the context of biologic warfare or bioterrorism.231 671
Use only if infection known to be caused by penicillin-susceptible B. anthracis.671
Although 7–10 days may be adequate if cutaneous anthrax occurred as the result of natural or endemic exposure to anthrax,231 234 CDC, AAP, and others recommend 60 days of anti-infective treatment if cutaneous anthrax occurred as the result of exposure to aerosolized anthrax spores (e.g., in context of biologic warfare or bioterrorism).231 234 671
Adults
Pharyngitis and Tonsillitis
Oral
AHA recommends 50 mg/kg (up to 1 g) once daily for 10 days.375
IDSA recommends 50 mg/kg (up to 1 g) once daily for 10 days or 25 mg/kg (up to 500 mg) twice daily for 10 days.580
Ear, Nose, and Throat Infections
Oral
500 mg every 12 hours or 250 mg every 8 hours for mild to moderate infections.1
875 mg every 12 hours or 500 mg every 8 hours for severe infections or those caused by less susceptible bacteria.1
Respiratory Tract Infections
Oral
875 mg every 12 hours or 500 mg every 8 hours for mild, moderate, or severe lower respiratory tract infections.1
Skin and Skin Structure Infections
Oral
500 mg every 12 hours or 250 mg every 8 hours for mild to moderate infections.1
875 mg every 12 hours or 500 mg every 8 hours for severe infections or those caused by less susceptible bacteria.1
Urinary Tract Infections (UTIs)
Oral
500 mg every 12 hours or 250 mg every 8 hours for mild to moderate infections.1
875 mg every 12 hours or 500 mg every 8 hours for severe infections or those caused by less susceptible bacteria.1
Gonorrhea
Oral
Manufacturer recommends 3 g as a single dose.1
No longer recommended for gonorrhea by CDC.344
Typhoid Fever†
Oral
100 mg/kg daily or 1–1.5 g every 6 hours for 14 days.6
Helicobacter pylori Infection and Duodenal Ulcer Disease
Oral
1 g 2 times daily for 10 or 14 days given in conjunction with clarithromycin and either lansoprazole or omeprazole (triple therapy).1 168 172 173 174
1 g 3 times daily for 14 days given in conjunction with lansoprazole (dual therapy).1 168
Lyme Disease†
Erythema Migrans†
Oral500 mg 3 times daily for 14 days.329 331
Lyme Carditis†
Oral500 mg 3 times daily for 14–21 days.329 331 Use in outpatients when an IV regimen not required or as follow-up after an initial IV regimen.329 331
Lyme Arthritis†
Oral500 mg 3 times daily for 28 days.329 331
Chlamydial Infections†
Oral
500 mg 3 times daily for 7 days for treatment of chlamydial infections in pregnant women.344
Prevention of Bacterial Endocarditis†
Patients Undergoing Certain Dental or Respiratory Tract Procedures†
Oral2 g as a single dose given 30–60 minutes prior to the procedure.451
Anthrax†
Postexposure Prophylaxis of Anthrax†
Oral500 mg every 8 hours has been recommended.231 233 236
1 g every 8 hours recommended by CDC for adults (including pregnant and postpartum women) if exposure occurred in the context of biologic warfare or bioterrorism.672
Use only if penicillin-susceptible B. anthracis involved.672 673
Total duration of anti-infective prophylaxis should be ≥60 days.190 231 233 239 672
Treatment of Inhalational Anthrax†
OralInhalational anthrax in mass casualty setting when parenteral anti-infectives not available: 500 mg every 8 hours for 60 days.231
Treatment of Cutaneous Anthrax†
Oral500 mg every 8 hours has been recommended.231
1 g every 8 hours recommended by CDC for adults (including pregnant and postpartum women) for cutaneous anthrax without systemic involvement if infection occurred in the context of biologic warfare or bioterrorism.672
Use only if infection known to be caused by penicillin-susceptible B. anthracis.672 673
Although 7–10 days may be adequate if cutaneous anthrax occurred as the result of natural or endemic exposure to anthrax,231 234 CDC and others recommend 60 days of anti-infective treatment if cutaneous anthrax occurred as the result of exposure to aerosolized anthrax spores (e.g., in context of biologic warfare or bioterrorism).231 234 672
Prescribing Limits
Pediatric Patients
Neonates and Infants ≤12 weeks (3 Months) of Age
Oral
Maximum 30 mg/kg daily in divided doses every 12 hours.1
Special Populations
Renal Impairment
Dosage adjustment necessary in severe renal impairment.1 6 41 82 83
Do not use 875-mg tablets in those with severe renal impairment and GFR <30 mL/minute.1
Dosage recommendations not available for pediatric patients with renal impairment.1
GFR (mL/min) |
Daily Dosage |
---|---|
10–30 |
250 or 500 mg every 12 hours depending on infection severity1 |
<10 |
250 or 500 mg every 24 hours depending on infection severity1 |
Hemodialysis Patients |
250 or 500 mg every 24 hours depending on infection severity; with an additional dose both during and at the end of dialysis1 |
Cautions for Amoxicillin
Contraindications
-
Known hypersensitivity to any penicillin.1
Warnings/Precautions
Warnings
Superinfection/Clostridioides difficile-associated Colitis
Possible emergence and overgrowth of nonsusceptible bacteria or fungi.1 21 Discontinue and institute appropriate therapy if superinfection occurs.1
Treatment with anti-infectives alters normal colon flora and may permit overgrowth of C. difficile.1 302 C. difficile infection (CDI) and C. difficile-associated diarrhea and colitis (CDAD; also known as antibiotic-associated diarrhea and colitis or pseudomembranous colitis) reported with nearly all anti-infectives and may range in severity from mild diarrhea to fatal colitis.302 Consider CDAD if diarrhea develops during or after therapy and manage accordingly.1 302
If CDAD suspected or confirmed, discontinue anti-infectives not directed against C. difficile as soon as possible.302 Initiate appropriate anti-infective therapy directed against C. difficile (e.g., fidaxomicin, vancomycin, metronidazole), appropriate supportive therapy (e.g., fluid and electrolyte management, protein supplementation), and surgical evaluation as clinically indicated.1 302
Sensitivity Reactions
Hypersensitivity Reactions
Serious and occasionally fatal hypersensitivity reactions, including anaphylaxis, reported with penicillins.1 6 51 53 55
Prior to initiation of therapy, make careful inquiry regarding previous hypersensitivity reactions to penicillins, cephalosporins, or other drugs.1 Partial cross-allergenicity occurs among penicillins and other β-lactam antibiotics including cephalosporins and cephamycins.1 6
If a severe hypersensitivity reaction occurs, discontinue immediately and institute appropriate therapy as indicated (e.g., epinephrine, corticosteroids, maintenance of an adequate airway and oxygen).1
General Precautions
Selection and Use of Anti-infectives
To reduce development of drug-resistant bacteria and maintain effectiveness of amoxicillin and other antibacterials, use only for treatment or prevention of infections proven or strongly suspected to be caused by susceptible bacteria.1
When selecting or modifying anti-infective therapy, use results of culture and in vitro susceptibility testing.1 In the absence of such data, consider local epidemiology and susceptibility patterns when selecting anti-infectives for empiric therapy.1
Hepatic Effects
Moderate increases in serum AST and/or ALT reported.1
Hepatic dysfunction, including cholestatic jaundice, hepatic cholestasis, and acute cytolytic hepatitis reported.1
Assess hepatic function periodically during prolonged therapy.1
Renal Effects
Assess renal function periodically during prolonged therapy.1
Hematologic Effects
Adverse hematologic effects (e.g., anemia, hemolytic anemia, leukopenia, agranulocytosis, thrombocytopenia, thrombocytopenic purpura) reported with penicillins.1 Usually reversible when drug discontinued; may be a hypersensitivity reaction.1
Assess hematologic function periodically during prolonged therapy.1
Mononucleosis
Possible increased risk of rash in patients with mononucleosis; use in these patients not recommended.4 29 54 60
Phenylketonuria
200- and 400-mg chewable tablets contain aspartame (NutraSweet), which is metabolized in the GI tract to provide 1.82 or 3.64 mg of phenylalanine, respectively.1 3
Oral suspensions do not contain aspartame and can be used in individuals with phenylketonuria (i.e., homozygous genetic deficiency of phenylalanine hydroxylase) and other individuals who must restrict their intake of phenylalanine.1
Specific Populations
Pregnancy
Category B.
Recommended as an alternative for various indications in pregnant women (e.g., treatment of chlamydial infections†,344 treatment of Lyme disease†,88 181 182 190 191 postexposure prophylaxis or treatment of anthrax†).672
Lactation
Distributed into milk; use with caution.1 4 6 26 49
Use in a breast-feeding woman may result in sensitization of infants.1
Recommended as an alternative for postexposure prophylaxis or treatment of anthrax† in women who are breast-feeding.239
Pediatric Use
Renal clearance of amoxicillin may be delayed in neonates and young infants because of incompletely developed renal function.20 27 32 62 128
Neonates and infants ≤12 weeks (3 months) of age should receive no more than 30 mg/kg daily given in divided doses every 12 hours.1
Tooth discoloration (brown, yellow, gray) reported rarely, most frequently in pediatric patients.1 Brushing or dental cleaning reduces or eliminates discoloration in most cases.1
Geriatric Use
Renal clearance may be decreased.
Hepatic Impairment
Assess hepatic function periodically during prolonged therapy.1
Renal Impairment
Assess renal function periodically during prolonged therapy.1
Dosage adjustments necessary in severe renal impairment.1 41 82 83
Common Adverse Effects
Adverse GI effects (e.g., nausea, vomiting, diarrhea), hypersensitivity reactions (e.g., rash).1 4 52 142
Drug Interactions
Specific Drugs and Laboratory Tests
Drug |
Interaction |
Comments |
---|---|---|
Allopurinol |
Possible increased incidence of rash;59 61 84 reported with ampicillin but no data regarding amoxicillin59 61 84 |
Unclear whether potentiation of rash is caused by allopurinol or hyperuricemia present in these patients59 61 84 |
Chloramphenicol |
In vitro evidence of antagonism1 |
Clinical importance unclear1 |
Clavulanic acid |
In vitro and in vivo synergistic bactericidal effect13 14 15 16 84 85 86 87 127 |
Used to therapeutic advantage in infections caused by β-lactamase-producing bacteria;84 commercially available in fixed combination with clavulanate potassium84 |
Macrolides |
In vitro evidence of antagonism1 |
Clinical importance unclear1 |
Methotrexate |
Possible decreased renal clearance of methotrexate;171 possible increased methotrexate concentrations and hematologic and GI toxicity171 |
Monitor closely if used concomitantly171 |
Probenecid |
Decreased renal tubular secretion of amoxicillin;1 23 24 34 increased and prolonged amoxicillin concentrations may occur1 23 24 34 |
|
Sulfonamides |
In vitro evidence of antagonism1 |
Clinical importance unclear1 |
Tests for glucose |
Possible false-positive reactions in urine glucose tests using Clinitest, Benedict’s solution, or Fehling’s solution;1 reported with ampicillin but no data regarding amoxicillin1 |
Use glucose tests based on enzymatic glucose oxidase reactions (e.g., Clinistix, Tes-Tape)1 |
Tetracyclines |
In vitro evidence of antagonism1 |
Clinical importance unclear1 |
Amoxicillin Pharmacokinetics
Absorption
Bioavailability
74–92% of an oral dose absorbed from GI tract.4 17 28 44 62
Peak serum concentrations usually attained within 1–2 hours.1 6 23 36 40 47
A 400-mg chewable tablet is bioequivalent to 5 mL of the oral suspension containing 400 mg/5 mL.1
Food
Food has minimal or no effect on bioavailability of oral amoxicillin.4 6 10 22 29 38 40 62
Special Populations
Oral absorption delayed in neonates compared with older children and adults;20 27 peak concentrations attained within 3–4.5 hours in neonates.20 27
Distribution
Extent
Readily distributed into most tissues and fluids1 following oral administration, including lungs,6 48 bronchial secretions,19 maxillary sinus secretions,4 bile,6 48 pleural fluid,6 sputum,4 6 30 and middle ear fluid.4 56 203
Only low concentrations attained in CSF.6 33 37
Crosses the placenta4 6 and is distributed into human milk.4 6 49
Plasma Protein Binding
Elimination
Metabolism
Probably metabolized to some extent in the liver.6 28 36 42
Elimination Route
Eliminated principally in urine by both glomerular filtration and tubular secretion.6
Approximately 50–80% of amoxicillin dose excreted unchanged in urine.1 6
Half-life
1–1.4 hours.1 17 21 29 36 43 46 50
Special Populations
Serum concentrations increased and half-life prolonged in patients with renal impairment.17 25 31 41 50 62
Renal clearance may be delayed in neonates and young infants because of incompletely developed renal function.20 27 32 128
Stability
Storage
Oral
Capsules
≤20°C.1
For Suspension
250 mg/5 mL: ≤20°C.1 Following reconstitution, refrigerate (preferable but not required) and discard after 14 days.1
200 or 400 mg/5 mL: ≤25°C.1 Following reconstitution, refrigerate (preferable but not required) and discard after 14 days.1
Tablets
200- and 400-mg chewable tablets and 500- or 875-mg film-coated tablets: ≤25°C.1
Actions and Spectrum
-
A β-lactam antibacterial classified as an aminopenicillin.6 62 The p-hydroxyl analog of ampicillin.62
-
Gram-positive aerobes: Active in vitro and in clinical infections against Staphylococcus (β-lactamase-negative strains only), Streptococcus pneumoniae, other Streptococcus (α- and β-hemolytic strains only), and Enterococcus faecalis.1 6 62
-
Gram-negative aerobes: Active in vitro and in clinical infections against H. influenzae, N. gonorrhoeae, E. coli, Corynebacterium diphtheriae,1 2 Listeria monocytogenes,1 2 Proteus mirabilis, Salmonella, and Shigella.1 4 6 8 10 62
-
Other organisms: Active in vitro and in clinical infections caused by H. pylori.1 6 Also active against Borrelia burgdorferi.6
-
Generally has same spectrum and level of activity as ampicillin,4 5 6 9 10 11 but more active than ampicillin against enterococci and Salmonella and less active against Shigella and Enterobacter.4 6 10 11 18
-
Resistance reported in gram-positive and gram-negative bacteria that produce β-lactamases, including β-lactamase-producing S. aureus and E. faecalis.5 6 8 9 10 11 12 79 129 130 131 132 133 134 135 136
-
Complete cross-resistance generally occurs between amoxicillin and ampicillin.4 5 6 9 10
Advice to Patients
-
Advise patients that antibacterials (including amoxicillin) should only be used to treat bacterial infections and not used to treat viral infections (e.g., the common cold).1
-
Importance of completing the entire prescribed course of treatment, even if feeling better after a few days.1
-
Advise patients that skipping doses or not completing the full course of therapy may decrease effectiveness and increase the likelihood that bacteria will develop resistance and will not be treatable with amoxicillin or other antibacterials in the future.1
-
Advise individuals with phenylketonuria and other individuals who must restrict their intake of phenylalanine that 200- and 400-mg chewable tablets contain aspartame (NutraSweet),1 which is metabolized in the GI tract to phenylalanine.89 90 91 92 93
-
Importance of discontinuing therapy and informing clinician if an allergic reaction occurs.1
-
Importance of informing clinician of existing or contemplated concomitant therapy, including prescription and OTC drugs.1
-
Importance of women informing clinicians if they are or plan to become pregnant or to breast-feed.1
-
Importance of advising patients of other important precautionary information.1 (See Cautions.)
Preparations
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.
* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name
Routes |
Dosage Forms |
Strengths |
Brand Names |
Manufacturer |
---|---|---|---|---|
Oral |
Capsules |
250 mg (of amoxicillin)* |
Amoxicillin Capsules |
|
Amoxil |
GlaxoSmithKline |
|||
500 mg (of amoxicillin)* |
Amoxicillin Capsules |
|||
Amoxil |
GlaxoSmithKline |
|||
For suspension |
125 mg (of amoxicillin) per 5 mL* |
Amoxicillin for Suspension |
||
Amoxil |
GlaxoSmithKline |
|||
Larotid |
||||
200 mg (of amoxicillin) per 5 mL* |
Amoxicillin for Suspension |
|||
250 mg (of amoxicillin) per 5 mL* |
Amoxicillin for Suspension |
|||
Amoxil |
GlaxoSmithKline |
|||
Larotid |
||||
50 mg (of amoxicillin) per mL* |
Amoxicillin for Suspension |
|||
Amoxil |
GlaxoSmithKline |
|||
400 mg (of amoxicillin) per 5 mL* |
Amoxicillin for Suspension |
|||
Amoxil |
GlaxoSmithKline |
|||
Tablets, chewable |
125 mg (of amoxicillin)* |
Amoxicillin Chewable Tablets |
||
250 mg (of amoxicillin)* |
Amoxicillin Chewable Tablets |
|||
Tablets, film-coated |
500 mg (of amoxicillin)* |
Amoxicillin Tablets |
||
875 mg (of amoxicillin)* |
Amoxicillin Tablets |
AHFS DI Essentials™. © Copyright 2024, Selected Revisions April 10, 2024. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.
† Off-label: Use is not currently included in the labeling approved by the US Food and Drug Administration.
References
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