How do you take Orkambi?
Orkambi should be taken every 12 hours with fat-containing food such as eggs, avocados, nuts, butter, peanut butter, cheese, and whole-milk dairy products. Granules are available for younger children aged one through five years and these should be mixed with one teaspoon of soft food or liquid. Other therapies prescribed for CF - including bronchodilators, inhaled antibiotics, dornase alfa, and hypertonic saline - should continue to be used if you are prescribed Orkambi.
Orkambi, is a combination therapy containing ivacaftor and lumacaftor that was approved for CF in July, 2015 for patients with two copies of the F508del mutation in their CFTR gene, who are aged 1 year and older. Inheriting two copies of the F508del mutation (one from each parent) is the leading cause of CF.
Evidence shows Orkambi improves lung function in people with CF. Side effects may include shortness of breath, upper respiratory tract infection, nausea, diarrhea, or rash. Menstrual abnormalities, such as increased bleeding, may be experienced by some women.
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What is Fluimucil used for?
Fluimucil is a brand name for acetylcysteine sachets and tablets which may be used to clear phlegm and liquefy thick and viscous mucus secretions caused by respiratory conditions such as acute bronchitis, chronic bronchitis, cystic fibrosis, pneumonia, pulmonary emphysema, or bronchiectasis. It is a type of mucolytic. Fluimucil is available over the counter (without a prescription) in most countries that have it. Continue reading
What is Trikafta?
Trikafta is a triple combination therapy that contains elexacaftor, ivacaftor, and tezacaftor, which is approved for adults and children 2 years of age and older with at least one F508del mutation in the CFTR gene, or a mutation in the CFTR gene that is responsive to Trikafta based on clinical and/or laboratory data. Continue reading
How does Kalydeco work?
Kalydeco specifically targets the underlying cause of cystic fibrosis (CF) and is approved for adults, children, and infants aged 4 months and older with CF with one or more specific mutations in their CFTR gene that is responsive to Kalydeco. It allows the defective CFTR protein to work better and increases salt and water movement within the airways. This thins the mucus and makes it easier to cough out. Continue reading
Related medical questions
- What is the difference between Symdeko and Orkambi?
- How do the warnings differ between Symdeko and Orkambi?
- How does Symdeko work?
- What is the difference between Symdeko and Kalydeco?
- Can you take Symdeko with birth control pills?
- How are Symdeko tablets taken?
Drug information
Related support groups
- Orkambi (3 questions, 3 members)
- Ivacaftor/lumacaftor (2 questions, 3 members)
- Cystic Fibrosis (10 questions, 29 members)