How do you use Dupixent?

Dupixent (dupilumab) is a prescription injection used to treat various inflammatory conditions, including:

• Eczema
• Asthma (add-on treatment)
• Chronic rhinosinusitis with nasal polyps
• Eosinophilic esophagitis
• Prurigo nodularis
• Chronic obstructive pulmonary disease (add-on treatment)

Your healthcare provider will train you on the proper technique to inject Dupixent.

Approved Uses and Age Guidelines

Dupixent is FDA-approved for the treatment of:

• atopic dermatitis (eczema) in adults and children aged 6 months and older
• asthma in adults and children aged 6 years and older
• chronic rhinosinusitis with nasal polyposis in adults and children 12 years and older
• eosinophilic esophagitis in adults and children aged 1 year and older
• prurigo nodularis in adults
• chronic obstructive pulmonary disease (COPD) in adults (eosinophilic phenotype)

Administration and Dosage

Dupixent is administered via subcutaneous (under-the-skin) injection every 2 weeks or every 4 weeks, depending on the condition and patient weight.

• Dupixent pre-filled pen: For adults and adolescents 12 years and older. In adolescent patients, the dose should be administered by, or under the supervision of an adult.
• Dupixent pre-filled syringe: For children 6 months and older. The dose should be administered by a caregiver.

Injection Instructions

The injection can be administered into the:

• Thigh
• Stomach (except for the 2 inches (5 cm) around the belly button)
• Outer upper arm (if administered by a caregiver)

Choose a different injection site for each injection. DO NOT inject Dupixent into skin that is tender, damaged, bruised, or scarred.

• See Dupixent Dosage

Related questions

• What are the most common skin conditions? (with photos)
• Why do Dupixent injections hurt so much?
• How fast does Dupixent work?

Using the Single-Dose Pre-filled Pen

The Dupixent pre-filled pen is a single-dose device for use in adults and children aged 12 years and older.

1. Prepare the injection site – Clean the area with an alcohol wipe and let it dry.
2. Remove the green cap – Hold the pen upright and do not touch the needle.
3. Position the pen – Place the yellow needle cover against the skin at a 90-degree angle.
4. Inject the medication – Press down firmly until the yellow needle cover is no longer visible. A “click” will indicate the injection has started, and the window will turn yellow.
5. Hold and complete injection – Keep holding the pen until you hear a second “click.” Count to five before removing the pen.
6. Dispose of the used pen – Place the used Dupixent Pre-filled Pen and green cap into an FDA-cleared sharps disposal container. Do not dispose of it in household trash.

Important Notes

• If the window does not fully turn yellow, do not administer another dose. Contact your healthcare provider.
• If you notice blood at the injection site, dab lightly with gauze. Do not rub.

This is not all the information you need to know about Dupixent (dupilumab) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.