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How do you administer/inject Firazyr?

Medically reviewed by Carmen Pope, BPharm. Last updated on Feb 26, 2025.

Official answer

by Drugs.com
Firazyr (icatibant) is administered by injection under the skin (subcutaneously). People with HAE are usually taught how to administer it to themselves, but it can be administered by a trained health professional experienced at treating HAE.

How do you administer Firazyr?

Firazyr is given by subcutaneous (under the skin) injection into the abdominal area. A nurse or doctor should teach you how to self administer Firazyr before you try yourself alone.

  1. First, wash your hands with soap and water. Decide where you will inject the Firazyr; choose an area that is free from scars or is not bruised or painful at least 2 to 4 inches below your belly button on either side. Clean the injection site with an alcohol swab and allow to dry.
  2. Remove the prefilled syringe from the carton and remove the seal from the needle cap. Inspect the contents of the syringe. They should be clear and colorless. Do not use the injection if it contains particles, is cloudy, or an unusual color.
  3. Remove the protective cap from the end of the prefilled syringe by unscrewing the cap. Hold the syringe firmly and firmly screw the needle to the prefilled syringe containing the Firazyr.
  4. Hold the needle cap and remove the needle and syringe. Do not touch the plunger.
  5. Hold the injection like a pen and use your other hand to gently pinch the skin up on your injection site into a fold.
  6. Inject the needle into the skin fold at a 45 to 90-degree angle. Push the plunger slowly, releasing the Firazyr into the skin over at least 30 seconds.
  7. Release the skin fold and pull the needle out.
  8. Dispose of your used Firazyr syringe into an appropriate sharps container.
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