Xiidra vs. Restasis: Which is better for dry eye?

Xiidra (lifitegrast) and Restasis (cyclosporine) are prescription eye drops used to treat dry eye disease, but they work differently and have distinct characteristics.

Xiidra:

• Contains lifitegrast, an LFA-1 antagonist that reduces inflammation and improves tear quality.
• Recommended dosage is one drop in each eye twice daily.
• Can start working in as little as 14 days, but may take up to 12 weeks for some patients.
• Common side effects include eye irritation, discomfort, and an unusual taste.

Restasis:

• Contains cyclosporine, a partial immunomodulator classified as a calcineurin inhibitor.
• Recommended dosage is one drop in each eye twice daily.
• Takes up to 12 weeks for noticeable effects and up to 6 months for full benefits.
• Common side effects include temporary burning, redness, watery eyes, and blurred vision.

Key Differences:

• Xiidra works faster for some, while Restasis may take longer for full effect.
• They target different aspects of inflammation and tear production.
• Both can cause similar side effects, such as burning and stinging.

Usage Note:

• Do not use Xiidra and Restasis together unless directed by a doctor, as this can increase side effects.

Bottom Line:

Xiidra may offer quicker relief for some, but Restasis is also effective over a longer period. Discuss with your doctor to determine which is better suited for you.