Can Xiidra eye drops cause diarrhea?
Xiidra (lifitegrast ophthalmic) will not cause diarrhea. Diarrhea is not listed as a potential side effect of using Xiidra, and there is no indication that proper administration of Xiidra in the eyes is associated with diarrhea.
Xiidra is a prescription ophthalmic solution, meaning it should be applied directly to your eyes. It is not intended to be swallowed. Oral ingestion of Xiidra may be harmful.
Xiidra contains lifitegrast. Over-the-counter eye drops containing a different compound, tetrahydrozoline, are well-known to be poisonous when swallowed, including Eye-Sine, Visine Original, Visine Advanced Relief and Opti-Clear. There is a common belief that consuming these eye drop solutions will cause diarrhea. While ingesting eye drops could result in diarrhea, it is not the primary or most common outcome. Swallowing eye drops containing tetrahydrozoline is harmful and potentially life-threatening. Symptoms of tetrahydrozoline poisoning include:
- Blood pressure changes
- Nausea
- Vomiting
- Seizures
- Coma
- Difficulty breathing
Xiidra does not contain tetrahydrozoline, but is still considered potentially harmful when swallowed.
References
- U.S. Food and Drug Administration (FDA). XIIDRA (lifitegrast ophthalmic solution) 5%, for topical ophthalmic use. June 2016. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208073s000lbl.pdf. [Accessed August 24, 2021].
- U.S. Food and Drug Administration (FDA). Deputy Division Director Review: Xiidra (lifitegrast ophthalmic solution) 5%. October 5, 2015. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208073Orig1s000SumR.pdf. [Accessed August 24, 2021].
- Shire. Safety Data Sheet: Xiidra. August 10, 2016. Available at: https://imgcdn.mckesson.com/CumulusWeb/Click_and_learn/SDS_9SHIRE_XIIDRA_DRPS_OPHTH_5_2ML_60_BX.pdf. [Accessed August 24, 2021].
- Australian Department of Health. Australian Public Assessment Report for Lifitegrast. November 2019. Available at: https://www.tga.gov.au/sites/default/files/auspar-lifitegrast-191107.pdf. [Accessed August 24, 2021].
- U.S. National Library of Medicine MedlinePlus. Tetrahydrozoline poisoning. January 1, 2021. Available at: https://medlineplus.gov/ency/article/002590.htm. [Accessed August 24, 2021].
- National Capital Poison Center. Swallowing Eye Drops is Dangerous. Available at: https://www.poison.org/articles/swallowing-eye-drops-is-dangerous. [Accessed August 24, 2021].
Read next
Xiidra vs. Restasis: Which is better for dry eye?
Xiidra (lifitegrast) and Restasis (cyclosporine) are prescription eye drops used to treat dry eye disease, but they work differently and have distinct characteristics. Continue reading
How much is Xiidra without insurance?
Xiidra (lifitegrast 5%) costs around $748 for a 30-day prescription if you are paying cash using an online coupon. Xiidra is an eye drop used for the treatment of the signs and symptoms of dry eye disease. Continue reading
Can Restasis and Xiidra be used together?
Only use Xiidra and Restasis together if your doctor has recommended this treatment. Both drugs are used to treat dry eye disease and inflammation and you would not usually need to combine them. Both Xiidra and Restasis can be linked with similar side effects such as eye burning, stinging and irritation. Continue reading
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Drug information
- Xiidra Information for Consumers
- Xiidra prescribing info & package insert (for Health Professionals)
- Side Effects of Xiidra (detailed)
- Xiidra user reviews (449)
Related support groups
- Xiidra (13 questions, 21 members)