Why does Imitrex (sumatriptan) make me feel weird?

Imitrex (sumatriptan) can cause a variety of side effects, which may make you feel weird after taking it. Side effects you experience from Imitrex can depend on which dosage form you’re taking. It is not fully understood what causes these side effects, but some could be related to how Imitrex affects blood vessels and nerves.

Rare side effects that can occur from taking any form of Imitrex include abnormal heart rhythm, vision loss, high blood pressure, seizures, and tightness in the chest, throat, neck, or jaw. If you are having severe symptoms, such as trouble breathing or hives, get medical attention right away.

Side effects of Imitrex nasal spray

Imitrex nasal spray is available in 5 mg, 10 mg, and 20 mg strengths. The following side effects were reported during clinical studies of Imitrex nasal spray:

• Bad or unusual taste: 13.5% to 24.5%
• Nausea and/or vomiting: 11% to 13.5%
• Nasal discomfort: 2.5% to 3.8%
• Throat discomfort: 0.8% to 2.4%
• Dizziness or vertigo: 1% to 1.7%

Imitrex nasal spray can also cause local irritation in the nose, including burning, numbness, discharge, and pain. These side effects usually go away within 2 hours.

Side effects of Imitrex injection

Imitrex injection is available in 4 mg and 6 mg strengths. The following side effects were reported during clinical studies of Imitrex 6 mg injection:

• Injection site reaction: 59%
• Tingling: 14%
• Dizziness or vertigo: 12%
• Warm or hot sensation: 11%
• Burning sensation: 7%
• Feeling of heaviness: 7%
• Pressure sensation: 7%
• Flushing: 7%
• Feeling of tightness: 5%
• Chest discomfort: 5%
• Weakness: 5%
• Neck pain: 5%
• Numbness: 5%

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Side effects of Imitrex tablets

Imitrex tablets come in 25 mg, 50 mg, and 100 mg strengths. The following side effects were reported during clinical studies of Imitrex tablets:

• Pain and pressure sensations: 6% to 8%
• Tingling: 3% to 5%

Tell your prescriber if you are experiencing bothersome side effects from Imitrex. They may be able to lower your dose or suggest ways to manage them.

This is not all the information you need to know about Imitrex (sumatriptan) for safe and effective use and does not take the place of your healthcare provider’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.