Why do Dupixent injections hurt so much?

Dupixent (dupilumab) injections can cause discomfort for some people. Factors affecting pain levels include:

• Medication temperature – Cold injections may be more painful.

• Injection technique – Proper technique can reduce discomfort.

• Pain tolerance – Individual sensitivity varies.

A healthcare professional will guide you on the correct injection method to help minimize pain.

What can you do to make Dupixent hurt less?

To reduce discomfort during and after your Dupixent injection, try these strategies:

• Let it warm up: Remove Dupixent from the refrigerator and allow it to reach room temperature (45 minutes for the 300 mg/2 mL pre-filled syringe or pre-filled pen, and 30 minutes for the 200 mg/1.14 mL pre-filled syringe or pre-filled pen).
• Rotate injection sites: Choose a different site to inject Dupixent each time.
• Use an ice pack: Apply for 15 minutes before injecting to numb the area.
• Consider numbing cream: Ask your doctor about topical anesthetics.
• Avoid rubbing the skin: This can worsen irritation.
• Wear loose clothing: Prevents additional pressure on the injection site.

For further guidance on how to reduce discomfort from Dupixent injections, consult your healthcare provider.

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Where Is the Least Painful Spot to Inject Dupixent?

Dupixent is a subcutaneous injection, which means it is injected under the skin. The recommended injection sites are:

• Self-injection: Thigh or stomach (excluding the 2-inch area around your belly button).
• Caregiver-assisted injection: Outer upper arms.

Pain levels vary by individual. Avoid injecting into bruised, scarred, or sensitive skin.

Can You Inject Dupixent Incorrectly?

Yes, incorrect injection technique may reduce effectiveness or increase pain. Follow these steps:

• Get trained: A healthcare professional should demonstrate proper administration.
• Wash hands and clean the site: Use an alcohol swab to prevent infection.
• Inject correctly: Dupixent should be injected under the skin (subcutaneously), not into a vein or muscle.
• Never inject through clothing.

If you have concerns, contact your doctor, pharmacist, or Dupixent MyWay Nurse Educators at 1-844-DUPIXENT.

This is not all the information you need to know about Dupixent for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.