What is the mechanism of action for Vabysmo?
Vabysmo (faricimab) works by blocking two pathways that cause abnormal blood vessel growth in the eye. It attaches to vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2), which stops them from working normally.
VEGF is a protein that plays a role in blood vessel growth and leakage. Ang-2 is also involved in blood vessel growth. By stopping these proteins from working, Vabysmo reduces abnormal blood vessel growth and leakage in the eye, which lessens swelling of the macula (the part of your retina responsible for central vision).
What is Vabysmo used for?
Vabysmo is FDA approved to treat patients with:
- Neovascular (Wet) age-related macular degeneration (nAMD)
- Diabetic macular edema (DME)
- Macular edema following retinal vein occlusion
How is Vabysmo given?
Vabysmo is an eye injection. It is injected into your eye every 4 weeks at first, and then the dosage will depend on what condition you are treating. You might experience temporary vision problems after your eye injection, so it is recommended to not drive until your vision recovers.
This is not all the information you need to know about Vabysmo (faricimab) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.
References
Akwii, R. G., et. al. 2019. Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology. In: Cells. DOI: https://doi.org/10.3390/cells8050471
Vabysmo (faricimab-svoa) prescribing information. Updated 07/2024. Genentech. [Accessed July 26, 2024]. Available at: https://www.gene.com/download/pdf/vabysmo_prescribing.pdf
Read next
What is the difference between Vabysmo and Eylea?
Vabysmo (faricimab) targets vascular endothelial growth factor (VEGF) and angiopoietin-1, whereas Eylea (afibercept) targets VEGF and placental growth factor (P1GF). Both agents are used to treat conditions such as macular degeneration (AMD) and diabetic macular edema and are given by intravitreal injection (into the gel part of the eye). Continue reading
Is Syfovre covered by Medicare?
Medicare Part B covers eye disease treatment Syfovre if you have geographic atrophy (GA) secondary to age-related macular degeneration (AMD). After you meet your Part B deductible, your cost is 20% of the Medicare-approved amount for the drug and services. Check with your Medicare plan for coverage details. Continue reading
Does Mounjaro cause blurry vision?
Treatment with Mounjaro can lead to rapid improvement in blood sugar levels and may temporarily worsen diabetic retinopathy, which can cause vision changes like blurry vision. Contact your doctor if you notice blurred vision, spots in your field of vision, flashing lights, or a sudden loss of vision while using this treatment. In addition, tell your doctor if you have a history of diabetic retinopathy before you start treatment. Continue reading
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Drug information
- Vabysmo Information for Consumers
- Vabysmo prescribing info & package insert (for Health Professionals)
- Side Effects of Vabysmo (detailed)
Related support groups
- Vabysmo (4 questions, 5 members)
- Macular Degeneration (35 questions, 66 members)
- Diabetic Macular Edema (12 questions, 5 members)
- Macular Edema (10 questions, 13 members)
- Macular Edema Following Retinal Vein Occlusion (3 questions, 3 members)