What is the mechanism of action for Rystiggo?
Rystiggo (rozanolixizumab-noli) is a neonatal Fc receptor (FcRn) blocker used to treat generalized myasthenia gravis (gMG), an autoimmune disorder affecting nerve-muscle communication.
Mechanism of Action
Rystiggo works by targeting a protein called neonatal Fc receptor (FcRn). By blocking FcRn, Rystiggo prevents autoantibodies from attaching to it instead. When autoantibodies attach to FcRn, they are recycled into the body instead of getting broken down.
By lowering autoantibody levels, Rystiggo helps reduce the immune system's attack on healthy nerve cells, improving muscle function in people with gMG.
References
Rystiggo [package insert]. (Revised June 2023). UCB, Inc. Accessed 06/14/2024 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3c0eb8c2-c042-4954-b451-3baa77f5e6d1
www.rystiggo.com. How Rystiggo works. Accessed 06/14/2024.
Zhu, L., et. al. (2023). FcRn inhibitors: a novel option for the treatment of myasthenia gravis. In: Neural Regeneration Research. Accessed 06/14/2024 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154512/
Read next
How long does it take Rystiggo to work?
Rystiggo (rozanolixizumab) starts to work as soon as 1 week after taking the first dose. In a clinical trial, patients taking Rystiggo saw improvement in activities of daily living that are typically affected by generalized myasthenia gravis by the end of 6 weeks of treatment. Continue reading
How does Mestinon help with myasthenia gravis?
Mestinon is a prescription medicine that can help relieve symptoms of myasthenia gravis (MG) such muscle weakness, double vision, blurred vision, drooping eyelids, loss of facial expressions, and difficulties with talking, chewing food, swallowing and breathing. There is no cure for MG, but treatments can help with symptoms. Continue reading
Can I stop taking Mestinon (pyridostigmine)?
Mestinon is a common treatment for myasthenia gravis but 25% of all patients who take it discontinue it because of side effects, and many discontinue it because it does not make any difference to their symptoms. Because it is short-acting, it could theoretically be stopped without tapering it, but you should always talk to your doctor about stopping it before you do so. Continue reading
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Drug information
- Rystiggo Information for Consumers
- Rystiggo prescribing info & package insert (for Health Professionals)
- Side Effects of Rystiggo (detailed)
- Rystiggo user reviews (2)
Related support groups
- Rystiggo (2 questions, 3 members)
- Myasthenia Gravis (18 questions, 96 members)