What happens when you stop Evenity?

Within months of stopping Evenity (romosozumab), the effects on bone formation and resorption start to decline.

• If stopped after three months, Evenity remains in the body for about two months.
• It can take up to 12 months for P1NP (a bone formation marker) and CTX (a bone resorption marker) to return to pre-treatment levels.

Do not stop Evenity without consulting your doctor, as discontinuation may increase fracture risk.

What is Evenity used for?

Evenity is an injectable medication used to treat osteoporosis in postmenopausal women at high risk for fractures. It is prescribed for women who:

• Have a history of osteoporosis-related fractures
• Have multiple risk factors for fractures

Evenity is only approved for up to 12 months of use.

How does Evenity work?

Evenity is a sclerostin inhibitor, meaning it promotes bone formation and reduces bone loss by blocking sclerostin, a protein that inhibits bone growth. Studies show that it:

• Increases the bone formation marker called procollagen type 1 N-telopeptide (P1NP), and
• Decreases the bone resorption marker type 1 collagen C-telopeptide (CTX)

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What Is the Half-Life of Evenity?

After three doses (3 mg/kg per month for three months), Evenity has a half-life of 12.8 days. This means it takes 12.8 days for the body to eliminate 50% of the drug's maximum concentration.

Should You Stop Taking Evenity?

Talk to your healthcare provider if you need to stop taking Evenity. They can recommend other treatment options to keep your bones healthy and prevent fractures.

This is not all the information you need to know about Evenity for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.