What is the half life of Abilify?
The half-life of Abilify (aripiprazole) depends on factors such as your genetics, health conditions, and the formulation you are taking. A half-life is the amount of time it takes for a medication to reach 50% of its maximum concentration in your bloodstream.
- Abilify (aripiprazole) tablet, oral solution, orally disintegrating tablet: 75 hours
- Abilify Maintena (aripiprazole) extended-release injection: 29.9 days (300 mg every 4 weeks) and 46.5 days (400 mg every 4 weeks)
- Abilify Asimtufii (aripiprazole) extended-release injection: 29.4 days
How long does Abilify stay in your system?
The amount of time that Abilify stays in your system is based on the half-life of the specific formulation you are taking. It can also depend on how quickly your liver breaks down the medication, which is based on your genetics. In general, it takes about 15 days for the oral forms of Abilify to leave your body completely. For the injections, it can take between 5 and 8 months until all of the medication is gone.
This is not all the information you need to know about Abilify (aripiprazole) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.
References
Abilify [package insert]. (Updated November 2022). Otsuka America Pharmaceutical, Inc. Accessed July 19, 2024 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c040bd1d-45b7-49f2-93ea-aed7220b30ac
Abilify Asimtufii [package insert]. (Updated January 2024). Otsuka America Pharmaceutical, Inc. Accessed July 19, 2024 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=da4c07fd-1130-4341-bb44-63acfa4162be
Abilify Maintena [package insert]. (Updated February 2024). Otsuka America Pharmaceutical, Inc. Accessed July 19, 2024 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ee49f3b1-1650-47ff-9fb1-ea53fe0b92b6
Wang, Y., et. al. (2024). Population Pharmacokinetics and Dosing Simulations for Aripiprazole 2-Month Ready-to-Use Long-Acting Injectable in Adult Patients With Schizophrenia or Bipolar I Disorder. In: Clinical Pharmacology in Drug Development. DOI: https://doi.org/10.1002/cpdd.1397
Read next
Does Abilify cause weight gain?
Although Abilify (aripiprazole) has been found to cause less weight gain than other atypical antipsychotics, there is evidence that in certain people it can cause significant weight gain and it may be more likely to cause weight gain in people who are taking it for depression alongside other antidepressants. Side effects such as weight gain may be significant enough for some people to discontinue Abilify, even when it is working well to manage symptoms. Continue reading
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What antidepressants are usually taken with Abilify?
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Drug information
- Abilify Information for Consumers
- Abilify prescribing info & package insert (for Health Professionals)
- Side Effects of Abilify (detailed)
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