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What is a 10-Panel Drug Test and what does it detect?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on April 5, 2025.

Official answer

by Drugs.com

A 10-panel drug test is a widely used screening method designed to detect the presence of ten specific substances in a person's system. This test is commonly employed in workplaces, legal settings, and rehabilitation programs to identify potential substance abuse. It provides a more comprehensive analysis compared to the simpler 5-panel drug test, making it a preferred choice in environments where safety or compliance is critical.

What Does a 10-Panel Drug Test Detect?

The 10-panel drug test screens for five commonly abused prescription medications and five illicit street drugs. A typical 10-panel drug test tests for the following ten substances in the body:

  • Amphetamines
  • Cocaine
  • Marijuana (THC)
  • Opiates (e.g., codeine, morphine, heroin)
  • Phencyclidine (PCP)
  • Barbiturates (e.g., phenobarbital)
  • Benzodiazepines (e.g., Xanax, Valium)
  • Methadone
  • Methaqualone
  • Propoxyphene

There are some variations between 10-panel drug tests, and some panels may include slightly different opiate/opioid checks. For example, some labs have replaced methaqualone with oxycodone (OxyContin). Alcohol and nicotine are usually not included on standard 10-panel drug tests.

When is a 10-Panel Drug Test Used?

A 5-panel drug test is the most commonly used drug test, which was developed in the 1980s under the Drug-Free Workplace Act. However, some employers choose to use expanded panels like a 10-panel drug test. A 10-panel drug test is commonly used in the following scenarios:

  • Workplace testing: Employers in industries like transportation, healthcare, military, and law enforcement may require this test to ensure a drug-free environment.
  • Legal and probation settings: Courts may mandate testing for individuals on probation or involved in legal disputes.
  • Rehabilitation programs: Used to monitor individuals recovering from substance abuse.
  • Post-accident investigations: Administered following workplace accidents to determine if substance use was a contributing factor.

How Is a 10-Panel Drug Test Done?

The 10-panel drug test typically involves collecting a urine sample, although other methods such as hair, blood, or saliva tests may occasionally be used. Urine testing is the most common due to its simplicity, noninvasiveness, and cost-effectiveness. The test identifies drug metabolites—chemical byproducts left in the body after a substance has been metabolized. If these metabolites are detected at levels above a certain threshold, the result is reported as positive.

Specimen Collection

For a urine sample:

  1. Preparation: Avoid excessive hydration before the test to prevent diluted samples. Inform the administrator of any prescription or OTC medications.
  2. Collection: A urine sample is collected in a sterile cup, often under observation to prevent tampering (common in workplace settings). This means someone may need to be present while you give the sample to ensure it isn’t contaminated.
  3. Split Specimens: For legal or workplace tests, the sample may be split into two containers for initial screening and confirmatory testing.

For a hair sample, the test administrator will cut approximately 90 to 120 strands of hair near your scalp and place it in a foil package to be sent for testing.

Laboratory Analysis vs. Rapid/Instant Tests

Laboratory tests (also called confirmatory tests) use advanced methods like Gas Chromatography-Mass Spectrometry (GC-MS) or High-Performance Liquid Chromatography (HPLC) to confirm results. They can detect lower drug concentrations and distinguish between similar substances (e.g., prescription opioids vs. illicit drugs). Results may take 1-7 days.

Rapid or instant drug tests rely on immunoassay technology (e.g., test strips) for immediate results. These tests are prone to false positives from cross-reactivity with medications or food. Results are usually available within minutes.

Detection Window: How Far Back Does a 10-Panel Drug Test Go?

A 10-panel drug test detects substances based on their detection windows, which vary depending on the drug, dosage, frequency of use, and individual metabolism.

Approximate Detection Windows by Substance

Drug Detection Time in Urine Detection Time in Hair
Amphetamines 2-4 days Up to 90 days
Cocaine 2-5 days Up to 90 days
Marijuana (THC) 1-30 days (depends on usage) Up to 90 days
Opiates Up to 4 days Up to 90 days
Benzodiazepines 2-14 days (depends on drug) Up to 90 days
Barbiturates 3-14 days (depends on drug) Up to 90 days
Methadone Up to 10 days Up to 90 days
Propoxyphene Up to 4 days Up to 90 days
Methaqualone Up to 14 days Up to 90 days

PCP

Up to 7 days Up to 90 days

How Much Does a 10-Panel Drug Test Cost?

The cost of a 10-panel drug test varies based on the testing method, provider, and additional services.

  • Standard 10-panel urine tests start around $40, but get more expensive with add-ons such as GC-MS confirmatory testing or additional substances like alcohol and nicotine.
  • Hair follicle testing costs approximately $185. DOT-certified labs (e.g., SAMHSA-certified) often cost more than non-DOT options.
  • At-home kits are usually less expensive, starting around $50. However, they lack validity without lab confirmation.

Where Can I Get a 10-Panel Drug Test?

If you're looking for a 10-panel drug test, there are several options available depending on your location and preferences.

1. Drug Testing Centers

  • US Drug Test Centers: With over 20,000 locations nationwide, US Drug Test Centers provides 10-panel drug testing for individuals and employers. Lab partners include Quest Diagnostics and LabCorp. You can order a test online or call their helpline to schedule an appointment. They also offer same-day testing and instant results at some locations.

2. Online Services

  • Request A Test: You can order a 10-panel urine drug test online through Request A Test. They partner with LabCorp collection sites and other labs across the U.S., allowing you to choose a nearby location for sample collection. Results are typically available within 1–3 business days for negative tests.
  • US Health Testing: Offers lab-based 10-panel drug testing services with no doctor referral or appointment needed. You can schedule a test online and visit one of their certified labs nationwide for sample submission.

3. Medical Facilities

  • Hospitals, clinics, and some doctor’s offices may provide 10-panel drug testing services. These are often used for medical screenings or legal purposes and may require an appointment.

4. At-Home Testing Kits

  • If convenience is a priority, you can purchase at-home 10-panel drug test kits online or at pharmacies. These kits typically include urine dipstick tests that provide results within minutes. Note that at-home tests may not meet the requirements for workplace or legal purposes due to the lack of professional oversight.

5. Specialized Providers

  • DISA Global Solutions: DISA offers comprehensive workplace drug testing solutions, including 10-panel screens, through its extensive network of collection sites.

How to Choose the Right Option

When selecting a provider:

  • Consider whether you need the test for personal use, employment, or legal compliance.
  • Check if the facility is SAMHSA-certified (important for workplace testing).
  • Confirm turnaround times if results are time-sensitive.

How Do I Pass a 10-Panel Drug Test?

The most reliable method to pass a 10-panel drug test is abstaining from drug use. Detection times vary by substance, metabolism, and frequency of use. For example:

  • Cannabis (THC): 3–30 days (longer for chronic users).
  • Cocaine: 2–4 days.
  • Benzodiazepines: 3–8 days (up to weeks for long-acting variants)

Attempting to cheat a drug test is unethical and may violate workplace policies or laws. The safest approach is abstinence or disclosing prescribed medications to the testing administrator. Tampering with a test (e.g., using synthetic urine) may lead to legal or employment repercussions if discovered.

How is a 10-Panel Drug Test Different from Other Drug Tests?

The primary difference between drug tests lies in the number and type of substances they screen for:

  • 5-Panel Drug Test: Detects five common illicit drugs—amphetamines, cocaine, marijuana (THC), opiates, and phencyclidine (PCP). This test focuses on substances typically associated with workplace safety concerns and is widely used by private employers and government agencies like the Department of Transportation.
  • 10-Panel Drug Test: Includes all substances in the 5-panel test but adds five more—barbiturates, benzodiazepines, methadone, methaqualone, and propoxyphene. This broader scope makes it suitable for industries like healthcare, law enforcement, and other safety-sensitive professions where prescription drug abuse may be a concern.
  • 12-Panel Drug Test: Expands on the 10-panel by adding tests for substances like oxycodone and MDMA (ecstasy), providing an even more comprehensive analysis. This test is often used in addiction treatment or rehabilitation settings.

There are other types of drug tests available as well, including 4-panel, 6-panel, 7-panel, 8-panel, 9-panel, 11-panel, 14-panel, 15-panel, and 16-panel drug tests. Some are urine-only, while others additionally test hair. The 5-panel drug test is more affordable and widely available compared to more comprehensive drug tests, such as the 12-panel test.

DOT vs. Non-DOT Drug Tests

Drug testing requirements vary significantly between DOT-regulated and non-DOT programs. DOT positive tests have specific consequences, such as job termination or mandatory drug treatment. Non-DOT test consequences vary depending on the employer's policies.

DOT testing refers to drug and alcohol testing required by the U.S. Department of Transportation (DOT) for employees in safety-sensitive positions. These positions include:

  • Commercial motor vehicle drivers
  • Pilots
  • Railroad workers
  • Mass transit operators
  • Aviation security personnel

DOT tests screen for five substances (i.e., 5-panel drug test). Non-DOT testing follows employer policies and state laws, offering flexibility in testing protocols and substance panels.

DOT Testing Non-DOT Testing
Specimen Collection Strict protocols: split urine specimens, observed collections in specific cases (e.g., tampering, return-to-duty) Flexible methods: single specimen, no mandatory observation
Laboratories Must use HHS-certified labs for analysis Can use any lab, including non-certified facilities
Random Testing Rates Up to minimum 50% annual rate for safety-sensitive employees No federal mandate; rates determined by employer policy

Legal and Privacy Considerations

Drug testing, including the 10-panel drug test, is a common practice in workplaces and other settings to ensure safety and compliance. However, these tests raise important legal and privacy concerns that employers and employees must navigate carefully.

Workplace Policies

Employers often implement drug-free workplace policies to maintain safety and productivity. These policies must comply with federal and state laws. For example:

  • Pre-employment Testing: Employers can require drug tests as a condition of employment after a job offer is made. However, laws like California's prohibit discrimination based on off-duty cannabis use, requiring valid tests that target psychoactive compounds.
  • Random Testing: In many states, including California, random drug testing is restricted unless justified by safety-sensitive roles or federal regulations.
  • Written Policies: Employers are advised to provide employees with clear written policies outlining the purpose of drug testing, substances tested for, and consequences of positive results.

Consent Forms

Consent is a critical legal requirement in non-federal workplaces. Employers must obtain written consent before conducting a drug test to protect themselves from liability:

  • Authorization: Employees must authorize the collection of samples (e.g., urine or hair) for testing purposes.
  • Disclosure Agreement: Consent forms should specify that test results will be shared with the employer and relevant authorities.
  • Release of Liability: Employees typically sign a waiver releasing the employer from legal action related to test outcomes.

For federally regulated drug tests (e.g., Department of Transportation), explicit consent may not be required due to public safety priorities.

Medical Privacy

Drug test results are considered sensitive information and must be handled with confidentiality:

  • Confidential Records: Results should be stored in separate medical files, not general employee records, as per Equal Employment Opportunity Commission (EEOC) guidelines.
  • Limited Disclosure: Sharing results should be restricted to those who need to know, such as HR personnel or compliance officers. Frontline managers typically do not require access beyond pass/fail status.
  • HIPAA Exceptions: Federal drug tests are not covered under HIPAA since they are forensic exams rather than medical evaluations. However, underlying health conditions revealed by a positive test may be protected under the Americans with Disabilities Act (ADA).

Confirmatory Testing

To ensure accuracy and fairness, confirmatory testing methods like Gas Chromatography-Mass Spectrometry (GC-MS) are often used:

  • GC-MS Testing: This method provides precise identification of drug metabolites and eliminates false positives caused by cross-reactivity with other substances.
  • Legal Safeguard: Confirmatory testing protects employees from wrongful accusations and helps employers make informed decisions.

Clear policies, consent forms, confidentiality measures, and confirmatory testing are vital components of ethical and lawful drug testing practices. Consulting legal professionals ensures compliance with applicable laws while fostering trust between employers and employees

Conclusion

In summary, the 10-panel drug test is an essential tool for identifying substance use across various settings. Its ability to detect a wide range of substances makes it invaluable for promoting safety and compliance in workplaces and legal contexts. In addition to five commonly-abused prescription medications, it also tests for five illicit substances. There are various options of where to take a 10-panel drug test. Follow up with your healthcare professional or employer for more information about drug testing.

References
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