Does Vraylar increase or decrease dopamine?

Vraylar (cariprazine) is an atypical antipsychotic used to treat schizophrenia, bipolar disorder, and depression. It interacts with dopamine D2 and D3 receptors, acting as a partial agonist. This means it can increase or decrease dopamine activity depending on the brain’s dopamine levels, helping to restore balance. Research suggests these effects contribute to relieving depression symptoms and negative symptoms of schizophrenia.

How Does Vraylar Work?

The exact mechanism of Vraylar is not fully understood, but it is known to modulate serotonin and dopamine levels in the brain. Its effects include:

• Partial agonist activity at dopamine D2 and D3 receptors – this means it can both stimulate and block these receptors, depending on the existing dopamine levels in the brain.
• Partial agonist activity at serotonin 5-HT1A receptors – may enhance mood stabilization.
• Antagonist activity at serotonin 5-HT2A receptors – contributes to its antipsychotic effects.

In essence, Vraylar works to modulate dopamine levels, helping to stabilize them rather than causing a simple increase or decrease. This complex action is believed to be why it can be effective in treating both manic and depressive symptoms.

This is not all the information you need to know about Vraylar (cariprazine) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.