Does Ubrelvy affect the liver?

No clinically significant liver injury has been reported in studies or since Ubrelvy (ubrogepant) was launched in the U.S. in 2019. Ubrelvy is a CGRP receptor antagonist used to treat migraine headaches and was designed to minimize liver toxicity risks seen with some other drugs in its class.

Does Ubrelvy Cause Liver Toxicity?

A safety study that has been conducted to assess the hepatotoxicity of Ubrelvy in patients taking the drug daily or near daily did not find that it caused liver injury. In addition, only 1-2 percent of the patients who took part in the clinical trials of the drug had mild-to-moderate serum aminotransferase elevations, which was consistent with the results seen in patients who received a placebo. Serum aminotransferase levels were measured to check for signs of drug-induced liver injury.

Can I Take Ubrelvy with Liver Impairment?

Ubrelvy is metabolized by the liver, so drug exposure increases in patients with liver impairment. If you have liver problems, your healthcare provider might adjust your Ubrevly dose.

• Mild to moderate impairment: No dose adjustment needed.
• Severe liver impairment (Child-Pugh Class C): Initial dose should be 50 mg, with an optional second 50 mg dose at least 2 hours later if needed.

In patients without severe liver impairment, the recommended dose is 50-100 mg initially. A second dose of 50-100 mg may be taken at least 2 hours after the first dose if required. The maximum 24-hour dose for people without severe liver impairment is 200 mg. It is not known if it is safe to use Ubrelvy to treat more than 8 migraines in 30 days.

Related questions

• How do Ubrelvy, Qulipta and Nurtec compare for migraines?
• What are the new drugs for the treatment of migraine?
• Ubrelvy vs Imitrex (sumatriptan): How do they compare?

Conclusion

Ubrelvy has not been linked to liver toxicity, but patients with severe liver impairment should follow adjusted dosing recommendations. Always consult a healthcare provider before starting Ubrelvy, especially if you have pre-existing liver conditions.