What type of drug is Talzenna?
Talzenna (talazoparib) is a poly (ADP-ribose) polymerase (PARP) inhibitor that blocks PARP, a protein that is involved with cancer cell growth, regulation and repair. PARP inhibitors stop the cancer cells from being repaired which leads to cell death and a reduction in tumor growth.
PARP inhibitors are used to treat cancers that have mistakes in their DNA repair genes, such as with the BRCA gene mutation. PARP inhibitors are used to treat cancers such as: ovarian cancer, fallopian tube cancer, pancreatic cancer, peritoneal cancer, breast cancer and prostate cancer.
Talzenna (talazoparib) is a prescription medicine approved for the treatment of adults:
- with a locally advanced or metastatic BRCA-mutated (gBRCAm), human epidermal growth factor receptor 2 [HER2]-negative breast cancer. This cancer has low or no amounts of HER2 protein, an abnormal inherited gene called BRCA and has spread to other parts of the body (locally advanced or metastatic). Your doctor will determine if you can use this treatment based on an FDA-approved diagnostic test.
- with a certain abnormal inherited or acquired gene (homologous recombination repair (HRR), metastatic castration-resistant prostate cancer (mCRPC), in combination with enzalutamide (Xtandi). Castration-resistant prostate cancer no longer responds to a hormone therapy or surgical treatment to lower testosterone and metastatic means it has spread to other parts of the body.
- It is given as a once-daily oral treatment and can be taken with or without food.
Other PARP inhibitors include:
This is not all the information you need to know about Talzenna (talazoparib) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.
For a complete list of side effects, please refer to the individual drug monographs.
Related Questions
References
- Talzenna (talazoparib) prescribing information. Pfizer, New York, NY. Updated June 2023. Accessed July 3, 2023 at https://labeling.pfizer.com/ShowLabeling.aspx?id=11046
Read next
Related medical questions
- Does anastrozole cause hair loss?
- What is the success rate of Keytruda?
- Is letrozole a form of chemotherapy?
- What does anastrozole do to your body?
- What is the lifetime or cumulative dose for Adriamycin?
- Does Femara make your hair fall out?
- What is Herceptin? Is Herceptin a chemo drug? How does it work?
- Why give Taxol (Paxel) before carboplatin?
- Does letrozole affect blood sugar levels?
- Will insurance pay for the cost of Ibrance?
- How does AC (Adriamycin and Cytoxan [cyclophosphamide]) work for Breast Cancer?
- What is the success rate for Femara in breast cancer?
- What are 10 key Ibrance side effects to watch out for?
- Why do you need to take Xeloda with food?
- Is it common to lose hair AFTER stopping tamoxifen?
- What are the long-term side effects of Adriamycin?
- Which is better - Aromasin or Femara?
- How long can you stay on Herceptin and Perjeta?
- How long do you take Verzenio for?
- How long does Herceptin stay in your body?
- How common is hair loss with Ibrance?
- How does Ibrance kill cancer?
- What is Paxel called in the USA?
- Is Verzenio better than Ibrance?
- Is Ibrance a form of chemo?
- How long can you take Faslodex?
- How effective is Trodelvy?
- What happens after Herceptin treatment?
- Can you take Verzenio after Ibrance fails?
- How long does it take for Faslodex to start working?
Drug information
Related support groups
- Talzenna (1 questions, 3 members)
- Talazoparib (1 questions, 3 members)
- Breast Cancer (121 questions, 304 members)
- Prostate Cancer (54 questions, 154 members)