Is Stelara an immunosuppressant?

Yes, Stelara (ustekinumab) is an immunosuppressant. It is approved to treat certain forms of psoriasis, psoriatic arthritis and moderate to severe Crohn's disease and ulcerative colitis.

How Stelara Works

Stelara is a biologic medication that targets interleukin-12 and interleukin-23, two cytokines involved in immune system regulation. Cytokines are substances released by cells in the immune system that signal other immune cells to grow, respond or release other substances. They all work together to help the body prevent or fight infection. Some diseases, such as psoriasis and inflammatory bowel disease, are thought to be a result of an improper or exaggerated response of the immune system.

Risk of Infections

Since Stelara suppresses the immune system, it can increase the risk of bacterial, viral, or fungal infections. Patients should not start Stelara if they have an active infection. Before prescribing Stelara, doctors may conduct tests to check for tuberculosis (TB) or other underlying infections.

When to Contact Your Doctor

If you develop any symptoms of an infection, you should notify your health care provider right away. If you do develop an infection while on the medicine, your health care provider may have you stop taking it for a time.

Can Stelara Be Used with Other Immunosuppressants?

Yes, Stelara may be used alongside other immunosuppressive drugs, but this should be done under a doctor’s supervision to minimize the risk of infections and other complications.