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Can you take Xanax if you are on prednisone?

Medically reviewed by Drugs.com. Last updated on Oct 23, 2024.

Official answer

by Drugs.com

Yes, Xanax and prednisone can be taken together. There is only a minor interaction between the two. Minor interactions do not usually cause harm OR require a change in therapy. Your health care provider will determine if adjustments to your medication are needed.

Certain corticosteroids may decrease the plasma concentration of some benzodiazepines. The mechanism is related to induction of hepatic cytochrome P450 enzymes responsible for benzodiazepine metabolism. The clinical significance may depend on the dosage and duration of corticosteroid therapy and be of greater importance with oral administration of benzodiazepines.

Xanax and Prednisone Interactions Report

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How long does Xanax last for / stay in your system?

One dose of Xanax can last anywhere from 31 hours to 134.5 hours (5.6 days) in the body, depending on factors related to the individual who took it. However, the calming, relaxing, and sedative effects of Xanax usually wear off within about eight to twelve hours. Continue reading

Does Xanax help you sleep?

Xanax (alprazolam) will cause sedation, drowsiness and somnolence as a side effect but is not typically prescribed to help with insomnia (trouble sleeping) on a regular basis. Sleepiness after taking Xanax usually occurs within 15 to 45 minutes. Continue reading

How does Xanax make you feel?

When taken as prescribed, Xanax (alprazolam) can help people with anxiety disorders or panic attacks by promoting a feeling of calm. It can also make you feel drowsy and lightheaded and may make you less mentally alert, so operating machinery and motor vehicles is not recommended while taking Xanax until you know how it makes you feel. Continue reading

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